E*****m
发帖数: 25615 | 1 http://news.discovery.com/human/embryonic-stem-cells-trials.html?print=true
First Human Embryonic Stem Cell Trial Begins
The landmark trial could one day lead to a breakthrough in the treatment of
spinal cord injuries.
Thu Oct 14, 2010 11:50 AM ET | content provided by Karin Zeitvogel, AFP
Doctors have begun the first tests of human embryonic stem cells in patients
, treating a man with spinal cord injuries in a landmark trial of the
controversial process, the Geron Corporation said Monday.
The patient began the pioneering treatment Friday with an injection of the
biotech company's human embryonic stem cells, as part of a clinical trial
that aims to test safety and efficacy toward regaining sensation and
movement.
The treatment took place at the Shepherd Center in Atlanta, Georgia, a
spokeswoman for the hospital told AFP, declining to give further details due
to patient privacy concerns.
The Phase I trial is expected to involve around 10 patients. Participants in
the human trials must be severely injured and start treatment with Geron's
product, GRNOPC1, seven to 14 days after sustaining their injury.
Patients will be given a single injection of two million of Geron's GRNOPC1
cells in the trial.
Those taking part will be followed up for one year to monitor safety and
also to see if they have regained any sensory function or movement in their
lower extremities.
If the initial group of subjects shows no negative side-effects, Geron plans
to seek FDA approval to extend the study to increase the dose of GRNOPC1
and to include patients with "as broad a range of severe spinal cord-injured
patients as medically appropriate."
The ultimate goal for GRNOPC1 is to inject it directly into the spinal cord
lesions of injured humans where it would, Geron hopes, prompt damaged nerve
cells to regrow, enabling patients to eventually recover feeling and
movement.
Geron began working with human embryonic stem cells in 1999.
Back then, "many predicted that it would be a number of decades before a
cell therapy would be approved for human clinical trials," Geron's president
and chief executive Thomas Okarma said in a statement.
Okarma described Monday's start of the clinical trial as "a milestone for
the field of human embryonic stem cell-based therapies."
GRNOPC1 is made up of cells containing precursors to oligodendrocytes --
multi-tasking cells that occur in the nervous system.
Oligodendrocytes are lost in spinal cord injury, resulting in myelin and
neuronal loss which cause paralysis in many patients.
Preclinical studies of GRNOPC1 found that when it was injected into the
injury site of animals with spinal cord injuries, it migrated throughout the
lesion site and matured into oligodendrocytes.
Those oligodendrocytes then re-lined axons with myelin, the insulating
layers of cell membrane that wrap around the axons of neurons to enable them
to conduct electrical impulses.
The process produced biologicals that enhance the survival and function of
neurons, resulting in significantly improved locomotion in the treated
animals.
In the animal trials, GRNOPC1 was injected seven days after the injury was
sustained.
Every year, some 12,000 people in the United States sustain spinal cord
injuries, usually in automobile accidents or from falls, gunshot wounds and
sports. | E*****m
发帖数: 25615 | 2 歡迎反對幹細胞研究的基督徒評論， 尤其是那 99.99%
不知道 stem cell 怎麼回事的基督徒。
也歡迎非基不置可否， 尤其是那 99.99%
不知道 stem cell 怎麼回事的非基。 | b*****o
发帖数: 482 | | b*****o
发帖数: 482 | 4 我都不知道基为什么要反干细胞研究． 神的律法里有这一条吗？ | E*****m
发帖数: 25615 | 5 神懂什麼是細胞？
【在 b*****o 的大作中提到】
: 我都不知道基为什么要反干细胞研究． 神的律法里有这一条吗？
| m*********g
发帖数: 11102 | 6 神是由细胞组成的么？
【在 E*****m 的大作中提到】
: 神懂什麼是細胞？
| b*****o
发帖数: 482 | 7 你这是ＧＡ（Ｇｏｄ ａｔｔａｃｋ）本版不允许的
上次有人问神有没有那个器官 就被封了．
【在 m*********g 的大作中提到】
: 神是由细胞组成的么？
| E*****m
发帖数: 25615 | |
|
