w********o
发帖数: 1231 | 1 非常好，
copy 50g file， 就开始热了，
看了几个 yahoo 上的 1080p 的video， 就热的可以 煎鸡蛋了，不过palm area 还可
以， 热的地方是键盘最上方 , 但是 一旦 停下来， 很快就凉快了，这点很牛。
fan is super quiet, for the reason, you should watch apple's video on its
website, it uses asymmetric fan. |
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L*****y
发帖数: 4290 | 2 就看这个俩风扇抗灰能力怎么样了
非常好，
copy 50g file， 就开始热了，
看了几个 yahoo 上的 1080p 的video， 就热的可以 煎鸡蛋了，不过palm area 还可
以， 热的地方是键盘最上方 , 但是 一旦 停下来， 很快就凉快了，这点很牛。
fan is super quiet, for the reason, you should watch apple's video on its
website, it uses asymmetric fan. |
|
w********1
发帖数: 3492 | 3 Wed, 13 Jun 2012 06:27:21 PDT
Following yesterday's teaser teardown of the updated MacBook Air, iFixit has
now given Apple's new Retina MacBook Pro the same treatment.
Apple of course showed off a fair bit of the machines internals during the
keynote in order to promote all of the innovations included inside, but
iFixit's teardown still provides an interesting hands-on look at the
internals.
Unsurprisingly, the Retina MacBook Pro is not designed to be user-accessible
, with the slim form factor ... 阅读全帖 |
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l**n
发帖数: 7272 | 4 1080p
8 hours ago at 06:31 am
In B4 the non-believer - in denial - "Why a taller iPhone???!!!?!!!?" crowd
shows up.
MacRumor crowd lately:
"Why a taller iPhone?"
"I am still hoping for a 4.3 wider iPhone!!!"
"It looks like the 4S! I want a dramatic redesign!"
"It doesn't look comfortable!"
"Tim is doubling down on secrecy! These are fakes!"
"Why is the headphone jack on the bottom? That's so stupid and asymmetrical!"
"The design is awful! I'll be sticking with my 3GS!"
"Steve NEVER would have al... 阅读全帖 |
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i******r
发帖数: 373 | 5 要在数据库里存一些用户sensitive data，各位有否经验分享？asymmetric的方法我不
明白应该如何在网站价格里保存private key，肯定还是存在server上，那么跟存
symmetric的密
钥有什么区别？谢谢！ |
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y********o
发帖数: 2565 | 6 Yes, I understand public-key encryption. I was asking if the type of encryp
tion you were talking about in SQL Server is asymmetric.
encryption.
connected to private key, i.e. you encrypt the data using the public key,
then to decrypt it, you must use the corresponding private key. As you have
said, HASH is one-way, no d |
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L******t
发帖数: 1985 | 7 Assume a mechanism exists in BT that more upload yields more download. Then
whisper is right that symmetrical networks get better performance than
asymmetrical ones that most of us are using, at least in a theoretical sense.
But another factor in whisper's case is the datacenter -- big bandwidth and
powerful processors may play a much bigger role here than symmetry or not.
My 0.02.
着当地的民兵组织打了一晚的猎。教我好生羡慕。
老师睡了，杰米森也睡了，只有一个仆役醒着，因为他开车。
我莞尔，拿出预先盛满清水的竹筒，打开，轻轻捏着竹筒里头水蛭那虚弱、缩
小的身体，小心翼翼地放在杰米森肥肥的脖子後的衣领里。
水 |
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m**t
发帖数: 1292 | 8
等有了802.16e version 可能还比较好用，否则这asymmetric 速率对很多双向通讯要
求高的应用来讲很不乐观 |
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p**x
发帖数: 123 | 9 any devices added to the network recently? stable network doesn't mean
routing path dont change. check if any asymmetrical routing somewhere. |
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b***p
发帖数: 700 | 10 1) /24是最小的单位，不可能ISP给你Advertise更细的，不然的花，BGP Table就要增
加10倍
2）你是video contents provider，下行Traffic远大于上行的，为什么要care用户
ingress route? 你做好自己的engineering进行啊，是用的TCP？担心Asymmetric
paths?
3) 你的客户如何Fail over是他们和ISP的事情，你也管不到, 你就是需要milti
homing, 两边都advertise，That's it
25 |
|
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g*****y
发帖数: 7271 | 12 现在不少license key的产生是用cryptography里的算法来做的。
比如asymmetric cryptology。你可以google一下 |
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n****1
发帖数: 1136 | 13 Your design is very similar to Apache Hbase, in which nodes are asymmetric.
Multiple master-node exist but only one master node is active, others are
ready to take over in case the active one fails.
I totally agree that CAP is satisfied if only eventual consistency is
required, because hbase already did that. Now please move on!
monolithic
granted
the |
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T********r
发帖数: 6210 | 14 from Solaris Internals: Core Kernel Components:
Sun's UNIX operating environment began life as a port of BSD UNIX to the
Sun-1 workstation. The early version of Sun's UNIX were known as SunOS,
which is the name used for the core operating system component of Solaris.
SunOS 1.0 was based on a port of BSD 4.1 from Berkeley labs in 1982.
In 1984, SunOS 2 offered the virtual file system framework...
The new virtual memory system, introduced as SunOS version 4...
An asymmetric multiprocessor implemen |
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f********n
发帖数: 6465 | 15 Yu, Y.-C., Bultje, R.S., Wang X., and Shi, S.-H. (2009) Specific synapses
develop preferentially among sister excitatory neurons in the neocortex.
Nature 458: 501-504.
Wang, X., Tsai, J.-W., Imai, J.H., Lin, W.-N., Valle, R.B., and Shi, S.-H. (
2009) Asymmetric centrosome inheritance maintains neural progenitors in
neocortex. Nature 461: 947-955. |
|
b*****b
发帖数: 14 | 16 急求 一篇文章
Polarized Myosin Produces Unequal-Size Daughters During Asymmetric Cell
Division
Guangshuo Ou, Nico Stuurman, Michael D'Ambrosio, Ronald D. Vale
Science express, published online 30 September 2010
谢谢！！
善心人请发至：n*****[email protected] |
|
l***m
发帖数: 26 | 17 读读吧：09 nature :Asymmetric centrosome inheritance maintains neural
progenitors in the neocortex.
读完就该知道了。 |
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p*****m
发帖数: 7030 | 18 不知道有没有上Mitbbs的哥们 hoho 看来至少北大不会把门槛提高哈
# Yuhui Whitney Yin，Ph.D 主讲 The mitochondria connection: from human
diseases to drug design
11:30 - 12:30, Dec. 15, 2010, Wed. 生命科学学院411会议室
# Wei Lu ，Ph.D 主讲 single-cell genetic analysis of synaptic glutamate
receptors
09:30 - 10:30, Dec. 15, 2010, Wed. 生命科学学院411会议室
# ZhuchengChen，Ph.D 主讲 Structure and Control of the ActinRegulatory WAVE
Complex
08:30 - 09:30, Dec. 15, 2010, Wed. 生命科学学院411会议室
# Dongyi Xu，Ph.D 主讲 Bloom’s Syndrome, genomic instability and cance... 阅读全帖 |
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a***a
发帖数: 40617 | 19 【 以下文字转载自 LosAngeles 讨论区 】
发信人: anoia (high estrogen man), 信区: LosAngeles
标 题: 黑色素瘤早期自我诊断
发信站: BBS 未名空间站 (Tue Dec 28 05:36:34 2010, 美东)
zz from wiki
http://en.wikipedia.org/wiki/Melanoma
A popular method for remembering the signs and symptoms of melanoma is the
mnemonic "ABCDE":
Asymmetrical skin lesion.
Border of the lesion is irregular.
Color: melanomas usually have multiple colors.
Diameter: moles greater than 6 mm are more likely to be melanomas than
smaller moles.
Enlarging: Enlarging or e... 阅读全帖 |
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m*p
发帖数: 226 | 20 Not sure either. The maternal mRNAs and proteins are symmetrically or
asymmetrically distributed to the two
daughters is not sure. |
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m***f
发帖数: 1622 | 21
扯淡呢，看看高最近两年发表的文章吧
CELL STEM CELL, JBC, STEM CELL, PNAS，都是很不错的
就这样还不能PROMOTION? 在美国都可以tennure了
1. Wu T., Wang H., He J., Kang L., Jiang Y., Liu J., Zhang Y., Kou
Z., Liu L., Zhang X., Gao S. (2011) Reprogramming of trophoblast stem
cells into pluripotent stem cells by Oct4. Stem Cells 2011 Feb 8.
[Epub ahead of print].
2. Kang L., Wu T., Tao Y., Yuan Y., He J., Zhang Y., Luo T., Kou Z.,
Gao S. (2010) Viable mice produced from 3-factor induced pluripotent
stem (iPS) cells through tetrapl... 阅读全帖 |
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f*********l
发帖数: 116 | 22 GOOGLE一下，此公不算一个吗
李华顺，理学博士，教授，博士生导师。1999年获Washington 大学神经生物学博士，
1999-2005在加州大学旧金山分校作博士后，2005-2007年在乔治亚州医学院作助理教授
，2007年7月到四川大学任教授，发育干细胞所研究员兼所长。研究方向是不对称性细
胞分裂、细胞极性、神经突起分化、干细胞和肿瘤干细胞。李华顺博士的工作曾发表在
Development 124, 603-615 （1997）; Cell 96, 807-818, (1999); Neuron 23, 473-
85 (1999); Neuron 40, 1105-18 (2003); Genes Dev. 19:138-51 (2005); Nat
Neurosci. 10:819-27 (2007).
Huashun Li Laboratory
Huashun Li, PhD, MD, Doctoral Tutor ,received his PhD from Washington
University in St.Louis in 1999, did postdoc... 阅读全帖 |
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s******a
发帖数: 472 | 23 http://www.cell.com/molecular-cell/fulltext/S1097-2765(11)00331
Fifty Years after Jacob and Monod: What Are the Unanswered Questions in Molecular Biology?
=====================================================================
Tomorrow's Molecular Biology
Marc W. Kirschner
Harvard University
Today, the term molecular biology has a rather prosaic sound. After all,
there is little in contemporary biology that isn't molecular. It's hard to
remember that 50 years ago, molecular biology was distinctly ... 阅读全帖 |
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M*******r
发帖数: 551 | 24 That is not true.
In the most recent issue, I found this contribution:
Asymmetric Lévy flight in financial ratios
Boris Podobnika,b,c,d,1,
Aljoša Valentinčičd,
Davor Horvatiće, and
H. Eugene Stanleya,1
+ Author Affiliations
aCenter for Polymer Studies and Department of Physics, Boston University
, Boston, MA 02215;
bSchool of Civil Engineering, University of Rijeka, 51000 Rijeka,
Croatia;
cDepartment of Finance, Zagreb School of Economics and Manag... 阅读全帖 |
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l**********1
发帖数: 5204 | 25 freshwater planarian Schmidtea mediterranea (涡虫)
Conclusion
Our investigation of clonal reproduction in the asexual strain of the
freshwater planarian S. mediterranea shows that these multicellular
organisms adopt a mixed strategy that com- prises both asymmetric binary
fission events (～70%) and fragmentation events (～30%) producing multiple
offspring.
cited from
//www.damtp.cam.ac.uk/user/jd548/Papers/2011QuThDuSc_JStatPhys.pdf
最近N年《Science》杂志刊登的m篇“涡虫”文献
//tieba.baidu.com/p/735402730
Ps:
FAQ ... 阅读全帖 |
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l**********1
发帖数: 5204 | 26 11th♂的细菌膜蛋白
>时间分辨常数大概在几秒到几十秒量级
那就是说细菌膜蛋白的铁离子通道 如果变化短于几秒 STORM无用武之地了吧?
打个比方用照相机 拍刘翔 百米跨栏的细节 想找到技术弱点 如可能改进后 伦敦奥运夺金牌
用傻瓜机的话是 南柯一梦吧 还得用D700 or MARKII 5D 吧
用电显的电子波长看不明白膜蛋白分子上的亚原子级别的实时动态变化的话
现实要看小于1.0 nm 的话
只有用 ESRF etc Synchrotron Radiation X-ray beam line
Freire F, Romão MJ, Macedo AL, Aveiro SS, Goodfellow BJ, Carvalho AL.
Preliminary structural characterization of human SOUL, a haem-binding protein.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jul 1;65(Pt 7):723-
Abstract
Human S... 阅读全帖 |
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c********r
发帖数: 1125 | 27 另外有关组成组分问题。
有质谱文章研究了组成和daugter/mother的区别问题了，但是有什么significance还谈
不上。。
EMBO J. 2011 Apr 20;30(8):1520-35. Epub 2011 Mar 11.
Novel asymmetrically localizing components of human centrosomes identified
by complementary proteomics methods. |
|
z*t
发帖数: 863 | 28 是不是上皮干细胞没有很合适的研究手段
我当时看他和clevers的Lgr5 neutral drift文章感觉好cool
但是后来发现好多Paper用不同marker都argue他们的结论，认为asymmetric是主流。
不过clevers后来说你们用的不是authentic stem cell marker...
Simons应该去祸害血液干细胞，发育的lineage清楚多了 |
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d*****r
发帖数: 2583 | 29 I agree with your conclusion, the reasons are different...
I think the major problem of creating a bio转专业版 is the maintenance and
development of the board. This process, from bio PhD to getting good job and
position from another field, is not an easy way out. Because most of the
time you need to go opposite way as the majority does around you.
This is similar to answers of question like "how to become Warren Buffet",
of course, the point is, one successful Warren Buffet will indirectly make
thou... 阅读全帖 |
|
d*****r
发帖数: 2583 | 30 I agree with your conclusion, the reasons are different...
I think the major problem of creating a bio转专业版 is the maintenance and
development of the board. This process, from bio PhD to getting good job and
position from another field, is not an easy way out. Because most of the
time you need to go opposite way as the majority does around you.
This is similar to answers of question like "how to become Warren Buffet",
of course, the point is, one successful Warren Buffet will indirectly make
thou... 阅读全帖 |
|
p********i
发帖数: 116 | 31 现在做这个的是不是都是用果蝇过着线虫来做，有没有人或者小鼠的stem cell 的分化
模型来做这个的？谢谢。 |
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p*****e
发帖数: 93 | 32 somebody ever used T cell to do this, but some people think that's not an
airtight story now. |
|
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c******8
发帖数: 36 | 34 如果你有很好的标志物，就很容易做了。前段时间，我们也打算做。不过那一只老鼠要
2000块。
我们是做HSC。但是我们很多都是体外做。 |
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w*e
发帖数: 740 | 35 能问问什么样的老鼠？
jackson的小鼠不就300块一对么？
难道你从欧洲买的？ |
|
w*e
发帖数: 740 | 36 果蝇的larva时期中枢神经系统神经干细胞的特异的分裂方式，很适合研究非对称分裂
，不过现在小鼠和人的脑细胞（比如outer radial glial cells）理论上也是很好的模
型。 |
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a****d
发帖数: 1919 | 37 The radial glia cells divide asymmetrically and produce precursor/immature
neurons, which migrate along the radial process up towards the cortical
plate.
Neurons were born first,the glia cells were produced later during cortical
development. Both are originated from the radial glia cells. Recently there
are findings suggesting that glia cells divide locally at the upper cortex
to increase the glia population.
Hopefully this is helpful. |
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s*****g
发帖数: 87 | 38 Methylated CpG island里两条DNA链都被甲基化了。
请问有没有什么gene 或者 promoter上的 DNA 只有一条链能被甲基化？ |
|
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l**********1
发帖数: 5204 | 40 no thanks,
just learn each other! |
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p*****c
发帖数: 20445 | 41 Michael Rape, Ph.D.
University of California, Berkeley
Michael Rape’s love of science began in the basement of his parent’s house
, where he used to conduct rudimentary biochemistry experiments. Today, he
uses far more sophisticated methods to understand a complex process critical
to nearly all organisms: ubiquitylation. The term describes the attachment
of a regulatory protein called ubiquitin—named for its ubiquity—onto other
proteins. Ubiquitin tags communicate a wealth of information to the ... 阅读全帖 |
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s***a
发帖数: 43 | 42 【 以下文字转载自 Faculty 讨论区 】
发信人: SWJSJ (BC), 信区: Faculty
标 题: 调研了一下清华最近回去的PI
发信站: BBS 未名空间站 (Mon Dec 15 16:27:25 2014, 美东)
云老师发了个贴说清华目前的找人标准，很多人不相信。特地调研了一下清华生命学院
最近回去的人的情况，如云老师所说，绝大多数都有2cns，如果只有一篇cns，那基本
上还有>2的子刊。这个不仅仅局限于胖老师经常说的结构生物学，而是所有方向都基本
如此。
当然这些新回去的绝大部分都是千青（有些不是的是因为回去那一年千青还没开始）。
网页上的Title有的是教授，有的是研究员，估计当时还没有统一。但校内一律都是副
教授，也就是相当于这边的AP。我还特地打听了一下，国内的TT制度好像没有Tenured
Associate这一档，清华5年考核通过了就是正经的full professor。
有些老师看不上国内的科研，我就仅列出两位回国后的publication，咱就不说颜宁等
这种Early T的个例了。说两个没太有名气的，还没有评上T的，各位老师可以参考一下
，... 阅读全帖 |
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z****u
发帖数: 1007 | 43 这个问题问得好。专门对干细胞衰老的研究好像没有。因为干细胞的传统定义就是life
long maintenance.理想得被定义为永远具有更新能力。自然不具有衰老问题。
我也在琢磨这个问题，如果在病理状况下，比如我contituional activate某signal
pathway 来不停的激活qienscent stem cell,那他们会不会最终衰竭。再比如糖尿病的
创口不愈合是否就是由于干细胞的提早衰老导致？
不对称分裂的行为在干细胞里研究很多。如楼上所说，在低等生物里常见到
asymmetrical division. 以此来维持stem cell population的总数问题。但在
mammalian里，不对称和对称分裂都有。比如复层化前的上皮干细胞的不对称分裂就类
似与
drosophila的 germ cell。symmetrical也不少 好像satellite cell就是, 对称分裂在
群体水平上，有的give rise to two progenitor, 有的give rise to two stem cell.
这样来维持群体数目的稳定。Elaine F... 阅读全帖 |
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s**********e
发帖数: 140 | 44 您提到"mammalian里，不对称和对称分裂都有",有什么根据吗？
有些看上去是对称分裂(symmetric division)实际上却是不对称分裂(asymmetric
division),并且有aging存在，例如fission yeast. 当然此结论目前还有争议。
life |
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x********e
发帖数: 35261 | 45 Yukiko和Xin好像都是M. Fuller实验室出来的，都是以果蝇germline stem cell为模型
做，她们两个人合作很密切。
Yukiko主要做GSC中心体对Asymmetric division的影响。她也用Brdu标记(之后用某种
酶降解template strand)看染色体在是不是优先分配到stem cell里，具体文章我没仔
细读过。
Xin是做histone不对称遗传的，前两年发了篇Science报告现象, 现在在接着做机制，
具体的就不说了哈。
XIN |
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j***z
发帖数: 105 | 46 Yes. Check out this one:
Asymmetrically modified nucleosomes. Cell. 2012 Sep 28;151(1):181-93. |
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l********n
发帖数: 260 | 47 1. Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J, Yuan J, Wang M,
Chen D, Sun Y, Woodward W, Liu Y, Dean DC, Liang H, Hu Y, Ang KK, Hung MC,
Chen J, Ma L. ATM-mediated stabilization of ZEB1 promotes DNA damage
response and radioresistance through CHK1. Nat Cell Biol. In Press.
2. Chen D, Sun Y, Yuan Y, Han Z, Zhang P, Zhang J, You MJ, Teruya-
Feldstein J, Wang M, Gupta S, Hung MC, Liang H, Ma L. miR-100 induces
epithelial-mesenchymal transition but suppresses tumorigenesis, migration
a... 阅读全帖 |
|
Q**********r
发帖数: 214 | 48 Nat Methods. 2007 Mar;4(3):257-62. Epub 2007 Feb 18.
Rapid SNP diagnostics using asymmetric isothermal amplification and a new
mismatch-suppression technology.
这几天在本版求了三篇文章了，真感谢大家在谢张争论的百忙中帮忙！ |
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