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全部话题 - 话题: cancer
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y*****s
发帖数: 1047
1
来自主题: Biology版 - recurrance of cancer
should be like you got cold last year and you got it again this year
IMHO, if one got cancer once, he/she is more prone to have mutataions and
therefore has better chance to get cancer again.
m********m
发帖数: 263
2
这个问题和我的ID相关,所以粗谈鄙人的一点陋见。与normal cell 相比,为了满足其
快速生长,cancer cell是,大量利用所有可利用的资源,但是是极其浪费的。原因无
非是各种原因引起的代谢途径的紊乱,所以代谢紊乱也经常被发现于cancer cell 内。
未来可能的走向无外于通过对于某个失调或突变的代谢途径或酶的研究以希望能给癌症
治疗带来契机,但是代谢过程往往是牵一发而动全身,而其影响代谢的 原因也可能千
变万化,所以道路是曲折的,但是混口饭吃还是可以的。
S*********s
发帖数: 304
3
Cancer metabolism是大牛玩的东西,新人慎入
Tak Mak-IDH1及一堆
Lewis Cantely -PKM2
Mien-Chie Hung - Keap1/NF-KB,EGFR等一堆
Inder M. Verma- cancer stem cell and metabolism
还有一些
原因在于很多问题没有确定的答案,大牛可以凭借以前的credit把story很漂亮地卖出
,New PI会很困难。
A******y
发帖数: 2041
4
If cancer is really addicted to sugar, you can cure any cancer simply by
putting your body in ketylosis. I think the big answer is NO!
m********m
发帖数: 263
5
这个问题和我的ID相关,所以粗谈鄙人的一点陋见。与normal cell 相比,为了满足其
快速生长,cancer cell是,大量利用所有可利用的资源,但是是极其浪费的。原因无
非是各种原因引起的代谢途径的紊乱,所以代谢紊乱也经常被发现于cancer cell 内。
未来可能的走向无外于通过对于某个失调或突变的代谢途径或酶的研究以希望能给癌症
治疗带来契机,但是代谢过程往往是牵一发而动全身,而其影响代谢的 原因也可能千
变万化,所以道路是曲折的,但是混口饭吃还是可以的。
S*********s
发帖数: 304
6
Cancer metabolism是大牛玩的东西,新人慎入
Tak Mak-IDH1及一堆
Lewis Cantely -PKM2
Mien-Chie Hung - Keap1/NF-KB,EGFR等一堆
Inder M. Verma- cancer stem cell and metabolism
还有一些
原因在于很多问题没有确定的答案,大牛可以凭借以前的credit把story很漂亮地卖出
,New PI会很困难。
A******y
发帖数: 2041
7
If cancer is really addicted to sugar, you can cure any cancer simply by
putting your body in ketylosis. I think the big answer is NO!
w**********u
发帖数: 290
8
来自主题: Biology版 - 求问Mayo Clinic cancer research 情况
由于家庭原因要去Mayo Clinic 那边, 求问版上兄弟姐妹们,有了解这个地方的
CANCER RESEARCH 怎么样?有哪些好的实验室和大牛?我知道这个医院是不错,USNEWS
在CANCER方面排名也挺靠前的,但就是不知道具体有那些好的实验室或者大牛什么的
?盼赐教。谢谢
b****r
发帖数: 17995
9
第一次听cancer cell metabolism这个题目我就觉得这玩意和脑白金差不多
人体内哪怕是正常细胞的能量来源都那么多,别说cancer cell这种往往怎么突变都做
得的的怪物了,走这条路怎么可能搞得死癌细胞,最多也就是抑制一会儿
G***G
发帖数: 16778
10
来自主题: Biology版 - MS/MS cancer data, 1baozi
I am looking for public MS/MS data for cancer.
Any cancer is ok.
If you happen to know where I can find it, please let me know.
1 Baozi will be used for thanks and reward.
thank you.
y*****s
发帖数: 1047
11
来自主题: Biology版 - MS/MS cancer data, 1baozi
what is MS/MS cancer data?
proteomics data from cancer patients plasma?
r**b
发帖数: 143
12
做cancer的人大部分都读过他的一篇review:The hallmarks of cancer
l**********1
发帖数: 5204
13
炸药生理医学奖的2013 Y 提名 RAW 被取消了吧
from this one:
HTTP : //www.sciencedirect.com/science/article/pii/S1535610803000308
more pls refer
同主题阅读:Re: 大家说说Cancer cell metabolism吧,这个越来越火啊!
[版面:生物学][首篇作者:lostashoe] , 2012年11月02日
http://www.mitbbs.com/article_t1/Biology/31748337_0_3.html
>>
打脸的文章出来了
http://www.ncbi.nlm.nih.gov/pubmed/23267074
M2 isoform of pyruvate kinase is dispensable for tumor maintenance and
growth.

alfa-
---
>>
发信人: Zebrafishing (饕餮), 信区: Biology
标 题: Re: 大家说说Cancer cell metabolism吧,这... 阅读全帖
l******u
发帖数: 936
14
If you mean CNS, there are probably only 2 match your description.
The GATA2 transcriptional network is requisite for RAS oncogene-driven non-
small cell lung cancer. Cell. 2012 Apr 27;149(3):642-55. doi: 10.1016/j.cell
.2012.02.059.
Glycine decarboxylase activity drives non-small cell lung cancer tumor-
initiating cells and tumorigenesis. Cell. 2012 Jan 20;148(1-2):259-72. doi:
10.1016/j.cell.2011.11.050. Epub 2012 Jan 5. Erratum in: Cell. 2012 Mar 2;
148(5):1066. Mitchell, Wayne [added]. .
b******s
发帖数: 1089
15
来自主题: Biology版 - 没人讨论这个cancer试纸么?
文章中间有更新:
(Update: Readers have pointed out that Andraka is not the first to create a
sensor of carbon nanotubes coated with antibodies. Here is a paper from 2008
by researchers at the University of Delaware who created an exceptionally
sensitive sensor for cancer breast cells, and a July 2009 paper from
researchers in South Korea working with prostate cancer cells.)
这个小孩正在申请专利,不知道其他研究者是否用同样的方法申请过专利。不过这孩子
出名了什么都会好办。
g*********s
发帖数: 350
16
【 以下文字转载自 EB23 讨论区 】
发信人: greattigris (I saw your body move), 信区: EB23
标 题: 求审稿机会, Cancer Biology的
发信站: BBS 未名空间站 (Fri Feb 22 12:38:57 2013, 美东)
本人有非常多年的经验在Cancer Biology, Signaling, Transcription 领域。 渴求
审稿机会。望有需要审稿的,请给机会帮忙。 谢谢先!
g*********s
发帖数: 350
17
【 以下文字转载自 EB23 讨论区 】
发信人: greattigris (I saw your body move), 信区: EB23
标 题: 求审稿机会, Cancer Biology的
发信站: BBS 未名空间站 (Fri Feb 22 12:38:57 2013, 美东)
本人有非常多年的经验在Cancer Biology, Signaling, Transcription 领域。 渴求
审稿机会。望有需要审稿的,请给机会帮忙。 谢谢先!
m**********3
发帖数: 706
18
oncogene, CLIN CAN RES, 再往下就INT J CANCER, CANCER LETT,
s******9
发帖数: 283
19
http://cancerresearch.org/postdoc/apply
Eligibility
1. Applicants for the CRI Irvington Postdoctoral Fellowship Program must be
working in areas directly related to cancer immunology. An eligible project
must fall into the broad field of immunology and must show relevance to
solving the cancer problem. Proposals that do not encompass both these areas
will not be considered.
2. Applicants must have a doctoral degree by the date of award activation
and must conduct their proposed research under a ... 阅读全帖
z***d
发帖数: 131
20
【 以下文字转载自 Immigration 讨论区 】
发信人: zymed (abcg), 信区: Immigration
标 题: 审稿机会 Cancer targeted therapy
发信站: BBS 未名空间站 (Thu Apr 4 02:18:19 2013, 美东)
最近很忙,EB1A材料也刚寄给律师。有意要推荐的,站内留名及e-mail address。
Keyword: lung cancer, targeted therapy.
Journal IF:1.0+
g**********y
发帖数: 423
21
您好,我做gastric cancer和breast cancer的targeted therapy。
在MSKCC和DUKE-NUS工作过。
求给我审稿机会。
My name: Zhengdeng Lei
Email: l**********[email protected]
m**e
发帖数: 857
22
来自主题: Biology版 - cancer vaccine的方向怎么样
cancer vaccine是特定对HPV而言么,还是把CANCER IMMUNOTHERAPY包括在内的?
m********8
发帖数: 157
23
If interested, drop me a line! thanks
A position is available as a Postdoctoral Associate or Associate Research
Scientist (Research Faculty) associated with the Yale Center for Analytical
Sciences and the Townsend Lab in the Department of Biostatistics at the Yale
School of Public Health. Our group uses high-throughput sequencing and
bioinformatic technologies to investigate genetics and gene expression
variation. We are particularly interested in candidates with strong
quantitative skills, pr... 阅读全帖
G***G
发帖数: 16778
24
来自主题: Biology版 - invasive cancer vs non-invasive
thank you.
Can I say, "this enzyme can test the invasiveness of breast cancer",
if what I want to express is 'this enzyme can test if the breast cancer
is invasive or non-invasive'?
C*********r
发帖数: 4
25
Recruiting ad hoc reviewers for cancer related journals. PhD with expertise
in cancer cell biology and/or molecular biology preferred.You will work with
the editor and follow journals' instruction to review manuscript and
provide constructive comments and suggestions. This is a volunteer activity.
If interested please reply to this mailbox with your current status (
student or postdoc, etc.), academic email contact, keywords describing your
expertise, and major publications (or PMID/Pubmed link)... 阅读全帖
w***a
发帖数: 1053
26
想什么呢
当然cancer res,如果很好可以试试cancer cell
影响因子不代表一切的,这2个杂志对于拿grant有很大帮助,美国普遍都认
c*******L
发帖数: 20
27
来自主题: Biology版 - 文献求助:nature review cancer
求一篇nature review cancer的文章:Inside the human cancer tyrosine
phosphatome
http://www.nature.com/nrc/journal/v11/n1/full/nrc2980.html
谢谢了
邮箱是:a****[email protected]
d*p
发帖数: 534
o******u
发帖数: 117
29
如题。国内一老师打算投cancer letter。但是这个杂志需要提供5个潜在审稿人的信息
....;我也不清楚这是哪门子规定。弱问一声,版上有这个杂志的审稿人吗?我自己是6
个杂志的审稿人,但不做cancer方向....。谢谢大家,欢迎私信联系。
s******a
发帖数: 10
30
OSU有thyroid cancer的SPORE
http://trp.cancer.gov/spores/abstracts/ohiostate_thyroid.htm

★ 发自iPhone App: ChineseWeb 8.6
w***r
发帖数: 709
31
来自主题: Biology版 - Fibroblast cell和cancer cell的区别
ras,src were cloned by transforming fibroblast at early days.
there are limitaion for sure,but even cancer cell line cannot reflect true
status, they have evolved during the isolation and passages in different
labs for years,and they are out of their niche. most of the people in cancer
field are biochemists,they want to know how molecules work.
f******g
发帖数: 1003
32
会议议题是cancer stem cell以及niche,cancer heterogeneity and clonal
evolution, aging.
具体信息请点击link:
http://www.grc.org/programs.aspx?id=13564
如果有什么好的数据想展示,就报名吧。会有不少牛牛来,目前正在邀请keynote
speaker, all the candidates are super star.
在会议开始前一两天,会有和几个牛牛见面,讨论。
s**********a
发帖数: 92
33
cancer 领域 postdoc。
是不是太不 productive了?
正在做的一个课题,我觉得能发篇 cancer research,运气好的话,可能发个稍微高点
的。
到现在三年,没有同步其他课题,至少没有有眉目的。当然中间也做过其他课题,但没
有下文。
老板也很push,自己干的也很奴隶,周末都带饭。
这种情况,看不到出路啊。
s**********a
发帖数: 92
34
对于breast cancer lung metastasis,现在发表的文章都是这样:knockdown一个基因
,lung metastasis 被抑制,但细胞生长不受影响。
我这个基因在 breast cancer cell 里面 knockout 后,lung metastasis 几乎完全被
抑制。但同时,细胞生长也受到抑制。请问这种情况下,是不是得先考虑细胞生长对
metastasis的影响?
谢谢!
d*****3
发帖数: 167
35
现在有没有比较全面的运用于临床的癌症遗传的筛查? 医院里的癌症中心都用那家的
cancer genetics panel test? 有看到用这个的:
GeneDx cancer pannel test
http://www.genedx.com/test-catalog/available-tests/comprehensiv
肿瘤遗传做的比较好的大学实验室,比如JHU,有什么用于临床的肿瘤遗传panel test
吗?
j******i
发帖数: 939
36
来自主题: Biology版 - 又是cancer相关Nature造假 (转载)
这cancer信号通路里边不会一半是假的吧 cancer里边还是immunotherapy实在 关键还
是要看疗效
c*****x
发帖数: 83
37
【 以下文字转载自 Immigration 讨论区 】
发信人: cookiex (checking。。棉花依旧), 信区: Immigration
标 题: review opportunity 1分多 cancer, cell biology
发信站: BBS 未名空间站 (Wed Jun 10 16:27:07 2015, 美东)
站内我你的简短介绍,邮箱,姓名。 最好背景相关。
cancer, cell biology,
多谢
z***d
发帖数: 131
38
【 以下文字转载自 Immigration 讨论区 】
发信人: zymed (abcg), 信区: Immigration
标 题: cancer genetics 审稿机会
发信站: BBS 未名空间站 (Mon Jul 6 13:08:48 2015, 美东)
忙于准备出游。若有意要推荐者,请站内留email和简单介绍。
keywords: gene polymorphism, prostate cancer, inflammation.
IF: 1+ journal.
c****d
发帖数: 36
39
杂志 Cancer Informatics (Libertas Academica)(无影响因子,PUBMED等收录)要发
表一个supplement,topic是computational approaches for analyzing cancer omics
data。现在招募guest editor 4-6名,任务就是帮忙约稿,周期大约12个月。Guest
Editor可免费发一篇自己选择的文章。如果感兴趣请站内联系(姓名和单位邮箱,研究
方向,主页,CV)。或发邮件到cauyrd AT gmail.com. 正式邀请信杂志会稍后发出。
O**********a
发帖数: 317
40
来自主题: Biology版 - 放化疗会不会引起新的cancer
原理好像是cancer细胞长得快,先被杀死。
但是,放疗用射线照,会诱导突变;化疗有一些DNA诱变剂。
那会不会引起新的cancer?

发帖数: 1
41
恩,我感觉挺像的。。
看上了几个老板,其中一个做human genetics的是个MD,自己有病人样品,主要做
exome和WGS,后续做mouse model实验,paper档次应该更高一些
一个做cancer genomics的是个PhD,主要是做血液病和breast cancer的WGS, 好像实
验做
得少些。 paper也不错,稍微弱一些
r**********e
发帖数: 587
42
我跟楼主一样的background
cancer genomics其实不也就是human genetics的一种么
我觉得你说的是human complex disease,类似糖尿病之类的
坦白说我觉得cancer更好,complex disease目前还处于算命阶段,摸不清病因
k***a
发帖数: 636
43
cancer不也是一种complex disease么?很多cancer基本也处于摸不清病因的阶段,都
差不多吧。
K**R
发帖数: 193
44

谢谢回复!
是cancer和代谢的研究相关的。cancer免疫 因为没有背景就算了
谢谢

发帖数: 1
45
最近genotype一个cancer cell line(neuroblastoma)的microsatellite (tandem
repeat)位点
大概三个月前测的是这个位点是homozygous有6个repeat
然后最近重新解冻另外一个stock,start cell culture,测量同样的位点,居然成了
heterozygous,一半仍然6个repeat,另外一半成了10个repeat;反复做了很多遍,换
了所有的reagent生怕是contamination,但结果还是一样。
问了lab technitian,这个neuroblastoma在我们实验室都是一样的来源,他也怀疑这
个repeat是不是dynamics的
三个月前的cell line的passage不记得了
最近这个cell line的passage大概是p10
我想问下,cancer cell line的genome microsatellite难道真的会传代传着传着就发
生了变化?如此不稳定?

发帖数: 1
46
Thanks
Suppose at passage 1 of cancer cell line, at certain loci, allele frequency
is 90% A and 10% B, that's what you mean by "并不是完全homogeneous"
Then keep cell passage and wait until P20, it becomes 10% A and 90% B, this
is genome instability that lead to more heterogeneity?
Is it because allele A itself directly being "mutated" into allele B, or
cancer cell carrying allele B compete better than allele A so B could
survive over A?

发帖数: 1
47
第一次发帖,尝试在这边求一下审稿机会。。万分感谢!
具体方向是:
cancer therapy
cancer metabolism
mitochondrial disease
tumor microenvironment
exosome
microvesicle
ectosome
有意者可站内~
G***G
发帖数: 16778
48
来自主题: Biology版 - cancer informatics 征稿
征稿,Cancer Informatics Toward Precision Medicine
http://www.frontiersin.org/research-topics/6859/cancer-informatics-toward-precision-medicine
M*P
发帖数: 6456
49
来自主题: Biology版 - cancer informatics 征稿
这家搞不下去了,找了很想搞绿卡的当guest editor

:征稿,Cancer Informatics Toward Precision Medicine
http://www.frontiersin.org/research-topics/6859/cancer-informatics-toward-precision-medicine
s******1
发帖数: 6
50
Immutics (www.immutics.com), located in Bay area, is a startup focusing on
discovery of novel drug targets for cancer immunotherapy through our unique
technique platform. So far several first-in-class drug targets have been
identified and antibody drugs have been developed and patented. We are
seeking a highly motivated individual with experience in immunology or
related fields to join us at this exciting moment. The primary focus of the
job is identification and characterization of novel target... 阅读全帖
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