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全部话题 - 话题: molecule
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O*******f
发帖数: 926
1
a recruiter at LinkedIn contacted me this Monday to see if I have friend(s)
who would be interested with this position. I just saw his message today.
Sorry, but any details in my hand yet. It seems focusing on small molecule
synthesis, I guess.
I can show you the recruiter's name at LinkedIn, and you may contact him
directly. Just give a try. No try, no opportunity. If not suitable, you just
move on.
Please throw your message to me internally. Thank you!
a***y
发帖数: 19743
2
【 以下文字转载自 Biology 讨论区 】
发信人: aaaty (阿fan提), 信区: Biology
标 题: Re: 业内人士来说说single molecule吧
发信站: BBS 未名空间站 (Tue Dec 6 23:41:13 2011, 美东)
现在否发现叶绿素可能使用了量子物理的原理来达到高效能量传递的结果
说不定生物体内有大量量子物理效应在发挥作用,大家还没发现。
以后做机理的大概要先学量子物理。
~~~
r****x
发帖数: 3613
3
another santa monica, i hope

Molecul
a****o
发帖数: 1786
4
【 以下文字转载自 Biology 讨论区 】
发信人: weir (weir), 信区: Biology
标 题: SIRT1 ACTIVTION BY SMALL MOLECULES-GSK与pfizer的STACs(SIRT
发信站: BBS 未名空间站 (Fri Aug 20 18:40:57 2010, 美东)
http://www.jbc.org/cgi/doi/10.1074/jbc.M110.133892
http://www.nature.com/news/2010/100816/full/news.2010.412.html
http://www.xconomy.com/boston/2010/08/12/former-sirtris-execs-nonprofit-starts-selling-resveratrol-with-potential-anti-aging-effects-online/?single_page=true
GSK与pfizer的STACs(SIRT1 activating compounds)之争
故事从Resveratrol(白藜芦
P******l
发帖数: 1648
5
来自主题: TrustInJesus版 - 血型的由来——反驳进化论者的批评
These are just google results from Apologetics websites for further study
and thoughts. Those who try to mess up with malicious attitude will get what
they deserve. On the other hand, we welcome sincere questions and are
willing to discuss about these together with mutual respect. Thanks.
http://askjohnmackay.com/blood-groups-how-a-b-ab-o-rh-blood-groups-from-adam-eve/
About the author: Diane Eager
Diane Eager has a background in medicine, and was a lecturer in biomedical
sciences at Univer... 阅读全帖
f**d
发帖数: 768
6
来自主题: Neuroscience版 - eBook: From computer to brain
这是一本计算神经科学的优秀著作,全文拷贝这里(图和公式缺),有兴趣的同学可以
阅读
如需要,我可以分享PDF文件(--仅供个人学习,无商业用途)
From Computer to Brain
William W. Lytton
From Computer to Brain
Foundations of Computational Neuroscience
Springer
William W. Lytton, M.D.
Associate Professor, State University of New York, Downstato, Brooklyn, NY
Visiting Associate Professor, University of Wisconsin, Madison
Visiting Associate Professor, Polytechnic University, Brooklyn, NY
Staff Neurologist., Kings County Hospital, Brooklyn, NY
In From Computer to Brain: ... 阅读全帖
b*******t
发帖数: 33714
7
来自主题: Food版 - [旧课件] meat
ppt直接导出来的,格式有点乱,不过有耐心的话看看还挺有意思的。
==================================
Part 3: Arts and Methods of Kitchen Arts
TOPIC: MEAT
Cooking meat
Cooking meat is all about producing the right texture and flavours.
Texture concerns the structure of meat.
Flavours are all about chemistry –the Maillard reaction.
Components of muscle
Water: 75%
Protein: 18%
Fat: ~4-10%, varies among different types of meat
Carbohydrate: just over 1%
Vitamins, minerals, various organic compounds…
Sliding-filament model of muscle... 阅读全帖
l*****7
发帖数: 8463
8
来自主题: Biology版 - 人也能光合作用!!!
1
http://disinfo.com/2011/05/could-human-photosynthesis-power-the-future/
Could Human Photosynthesis Power The Future?
Posted By: phunkychic666 MAY 4, 2011
Chlorophyll. Photo: Wilfredo R. Rodriguez H. (CC)
Chlorophyll. Photo: Wilfredo R. Rodriguez H. (CC)
By Hank Mills for Pure Energy System News:
Dr. Arturo Solis Herrera has developed a technology that utilizes the
properties of melanin – the animal analogue to chlorophyll. His melanin
based (polihydroxyindol) photo-cell absorbs a broad spectru... 阅读全帖
O**********0
发帖数: 61
9
☆─────────────────────────────────────☆
BHistory (往者的影子) 于 (Fri Sep 9 00:20:11 2011, 美东) 提到:
俺曾认为生命是进化起源的,后来越找越发现进化论像是信仰而非科学结论。可是每有
飞机网友觉着俺如此看待进化论是反科学了。
所以俺本着科学的精神,问个问题,求各位飞机进化论牛人给个科学的答案。
大家知道达尔文进化论是以遗传机制为基础的,第一个有遗传机制的生命怎么来的,当
时根本没有提及。
后人发现这一问题后,就又提出了化学进化论,就是无机分子在某种机制下,自动组合
出了第一个有遗传的生命。此后达尔文进化论似乎可以take care(其实未必,今后再
讨论)。
今天我们先看比第一个有遗传生命的出现简单万亿倍的问题,第一个蛋白质如何化学进化出
现?
先亮亮俺一个愚昧基督徒的愚见:
已知最简单的具有遗传机制的单细胞生命的复杂度已经远远超出人们最初的想象,大概
有400种蛋白质几十万个组成。其中较小的蛋白质大概100个氨基酸,如果在随机热运动
中组成,因为自然界对称的氨基酸不少于40种(20多种氨基酸及... 阅读全帖
W*****B
发帖数: 4796
10
来自主题: Military版 - “consistent
曾经有
In puffs of gas from rocks more than 3 billion years old dug up by one
of NASA's robotic explorers on Mars, scientists have identified several
complex organic molecules — possible building blocks for
ancient life.
It’s not aliens. (It’s never aliens.)
But it is “consistent with the past presence of biology,” said Ken
Williford, an astrobiologist at NASA's Jet Propulsion Laboratory. “And
it makes us more confident that if biomarkers” — or direct evidence of
biologic activi... 阅读全帖
D*****y
发帖数: 5788
11
【 以下文字转载自 TrustInJesus 讨论区 】
发信人: Dignity (饥不择食), 信区: TrustInJesus
标 题: [合集] 有请某文化人来说说进化论-三日为限
发信站: BBS 未名空间站 (Thu Dec 30 15:50:31 2010, 美东)
☆─────────────────────────────────────☆
jym2307 (罪魁) 于 (Tue Dec 7 19:14:10 2010, 美东) 提到:
从哪里说起都可以
只有一条,最好代表当今进化论的权威
否则不要天天浪费大家的时间跟你一起打酱油
基督版不是给你进化论妄想打酱油的地方
☆─────────────────────────────────────☆
jym2307 (罪魁) 于 (Tue Dec 7 19:16:08 2010, 美东) 提到:
给你三天时间放狗去找
够了吧?
☆─────────────────────────────────────☆
atep (嘚嘚) 于 (Tue Dec 7 23:28:47 2010, 美东... 阅读全帖
D*****y
发帖数: 5788
12
☆─────────────────────────────────────☆
jym2307 (罪魁) 于 (Tue Dec 7 19:14:10 2010, 美东) 提到:
从哪里说起都可以
只有一条,最好代表当今进化论的权威
否则不要天天浪费大家的时间跟你一起打酱油
基督版不是给你进化论妄想打酱油的地方
☆─────────────────────────────────────☆
jym2307 (罪魁) 于 (Tue Dec 7 19:16:08 2010, 美东) 提到:
给你三天时间放狗去找
够了吧?
☆─────────────────────────────────────☆
atep (嘚嘚) 于 (Tue Dec 7 23:28:47 2010, 美东) 提到:
请最虔诚的罪魁来说说基督教-三日为限
从哪里说都可以
该不该蒙头 该不该抹油 该不该搞基 该不该吃转基因食物
只有一条 要代表当今基督教的权威答案 好让这些问题有统一答案
给你三天时间 放狗去搜吧

☆─────────────────────────────────... 阅读全帖
E*****m
发帖数: 25615
13
要反進化論好歹要反人家相信的東西,自己樹立個稻草人打得不亦樂乎
做什麼?
拜託讀點書,讓別人有理由尊重你。
http://www.pbs.org/wgbh/evolution/library/faq/cat01.html
7. Is evolution a random process?
Evolution is not a random process. The genetic variation on which
natural selection acts may occur randomly, but natural selection itself is
not random at all. The survival and reproductive success of an individual is
directly related to the ways its inherited traits function in the context
of its local environment. Whether or not an individu... 阅读全帖
w********2
发帖数: 632
14
来自主题: Military版 - 我来说两句谢晓亮
我的意思是raman和ir都是分子振动这一级别的,nmr是原子核自转一级别的,别歪曲。
Comparison of Raman and IR Spectroscopy
By
Dr. Mehboob Peeran
Reviewed By
Dr. K.G. Srinivasamurthy
Mutual exclusion principle
In a molecule with a center of symmetry it is seen that vibrations that are
Raman active are IR inactive and vice-versa, this is called the Principle of
mutual exclusion (eg, as in CO2 see details in the end). In molecules with
different elements of symmetry, certain bands may be active in IR, Raman,
both or neither. For a compl... 阅读全帖
L*******a
发帖数: 824
15
来自主题: Movie版 - 我也说说Prometheus
看了很多fans的猜测 我觉得我同意坑理论 编剧也没决定整个的story line是什么样
的 非常的open好写前传续集
既然是瞎猜 我就说一下我想象中的story是什么样的
先说生命的起源
达尔文的进化论,所谓生命最多只能推回到第一个细胞生物 我们再大胆向前推一点
地球上的真正意义的上第一个生命应该是一个可以自我复制的分子 也就是DNA DNA之
后的故事科学界基本已经知道个大概了 但是第一个DNA分子从何而来 却不得而知
大多数科学家认为这是一个完全的随机现象 分子之间不断碰撞之后偶然形成了DNA
还有一小部分人认为DNA是design的(intellectual design)design DNA的是外星人或
者是我们所说的神。
这里就要和prometheus扯上关系了 电影中人类的DNA是从engineer来的 但是
engineer的DNA从何而来呢? 我个人认为 真正的生命起源是一另外一种物质(暂且叫
做the molecule)。 The molecule 能够把环境中的available的material打碎并利用这
些material... 阅读全帖
l**********1
发帖数: 5204
16
STORM living cell video recording barrier might be fixed by nonlinear
quantum
spectroscopy after 2017 AC (possible)
Alán Aspuru-Guzik Harvard Univ
his team one PNAS paper:
Quantum state and process tomography of energy transfer systems via
ultrafast spectroscopy.
Yuen-Zhou J et al. (2011)
PNAS 108:17615-17620.
key words:
processing ∣ open quantum systems ∣ quantum biology>
link:
//www.ncbi.nlm.nih.gov/pubmed/21997214
... 阅读全帖
l**********1
发帖数: 5204
17
STORM living cell video recording barrier might be fixed by nonlinear
quantum
spectroscopy after 2017 AC (possible)
Alán Aspuru-Guzik Harvard Univ
his team one PNAS paper:
Quantum state and process tomography of energy transfer systems via
ultrafast spectroscopy.
Yuen-Zhou J et al. (2011)
PNAS 108:17615-17620.
key words:
processing ∣ open quantum systems ∣ quantum biology>
link:
//www.ncbi.nlm.nih.gov/pubmed/21997214
... 阅读全帖
p*****c
发帖数: 20445
18
来自主题: Biology版 - The 2013 HHMI Investigators
Christopher D. Lima, Ph.D.
Memorial Sloan-Kettering Cancer Center
Christopher Lima doesn’t pick easy problems. A structural biologist, he is
investigating how cells attach small proteins—like ubiquitin and the
related molecule SUMO—to other proteins to modify their function or fate.
Alongside those studies, he is exploring the molecular mechanisms that
underlie RNA processing and degradation—modifications to an RNA copy of a
gene that influence its stability and ability to be used as a template ... 阅读全帖
s****l
发帖数: 10462
19
有人愿意讨论这里面提及的测序技术吗?优缺点,可行性,第一手经验等等
这里面谁现在是赢家很清楚,但是可见的将来和更远的将来谁会赢?
http://cen.acs.org/articles/92/i33/Next-Gen-Sequencing-Numbers-
全文拷贝如下
试试看图能不能贴上
/1407973177171.jpg
/1408028636124.jpg
OVER STORY
Next-Gen Sequencing Is A Numbers Game
As technical and cost barriers fall, instrument firms move their systems
into research and clinical markets
By Ann M. Thayer
Department: Business
Keywords: instrumentation, gene sequencing, diagnostics, genomics, cancer
[+]Enlarge
09233-cover-Openercxd_17647969-690
A... 阅读全帖
c****8
发帖数: 33
20
怎么能当上海科大的副校长?
EDUCATION:
1990 Ph.D. Inorganic Chemistry, Purdue University
1982 Undergraduate Education, East China Normal University, Shanghai,
China.
EXPERIENCE:
1998- Professor of Chemistry, Southeast Missouri State University
1994- Associate Professor of Chemistry, Southeast Missouri State University
1990-1994 Assistant Professor of Chemistry, Southeast Missouri State
University
1993 summer NASA JOVE Research fellow, Lewis Research Center, Cleveland, OH.
1991 summer Visiting Professor,... 阅读全帖
b*********n
发帖数: 1607
21
就用http://www.nap.edu/openbook.php?record_id=11876来说。下面的文字引用自他的
21-22页:
For life to begin, three conditions had to be met. First, groups of
molecules that could reproduce themselves had to come together. Second,
copies of these molecular assemblages had to exhibit variation, so that
some were better able to take advantage of resources and withstand
challenges in the environment. Third, the variations had to be
heritable, so that some variants would increase in number under
favorable environmental... 阅读全帖
w*****1
发帖数: 220
22
Dear Readers,
We are happy to present the first five papers that are published in our
new, open access journal, Physical Review X. These papers, together with
others that are to be published in the coming weeks into September, will
constitute the first issue of the journal. Under PRX's open access
publishing model, they are free for you to read and use.
We are very encouraged by the breadth of their topical spread. It ranges
from the well-established field of atomic, molecular and optica... 阅读全帖
c*******9
发帖数: 9032
23
来自主题: Physics版 - 大牛們評判一下這個
Summation of Tesla's Dynamic Theory of Gravity
An excerpt from: Occult Ether Physics
by William R. Lyne

From: Don Allen
d**[email protected]
According to Tesla's lecture prepared for the Institute of Immigrant Welfare
(May. 12, 1938), his "Dynamic Theory of Gravity" was one of two far
reaching discoveries, which he "...worked out in all details", in the years
1893 and 1894. The 1938 lecture was less than five years before his death.
More complete statements concerning these discoveries can ... 阅读全帖
g**********0
发帖数: 886
24
欧美制药业业在印度设厂实验室有他们的好处: 1.输出了污染大人力成本高的SECTION
, 2.有利
于做帐,高管与股市挂钩的利益来的快。 被老印山寨是这些利好的副作用。
下面这个报道说的是老印怎么用“法律”来忽悠的:
December 1, 2000
MEDICINE MERCHANTS / Pirated Pills
Selling Cheap 'Generic' Drugs, India's
Copycats Irk Industry
By DONALD G. McNEIL Jr.
Related Articles
• Issue in Depth: Medicine
Merchants
Forum
• Join a Discussion on Prescription
Medication
OMBAY — To anyone else, the room looks like the
unprepossessing office of a college science teacher.
But to the multinational pharmace... 阅读全帖
x********u
发帖数: 430
25
来自主题: Biology版 - Synergistic activity wanted
Thanks for your reply.
We use same inducer for all the experiments.
P should have same function with respect to X1-R2 and X2-R2. Once bound with
X1 or X2, both R1 and R2 should block the transcription of eGFP.
R1 and R2 recognize different inducer. The inducer for R2 is a universial
signaling molecule within all living organism.
One model currently I came up with is that X2 will interact with X1 and
decrease the binding affinity between R1 and X1, thus we saw an activation
effect when X1 is comb... 阅读全帖
x**2
发帖数: 255
26
来自主题: Biology版 - 求助!!头都想爆了
http://www.madsci.org/posts/archives/2002-04/1018464369.Cb.r.ht
The average distance that each type of molecule travels from
its starting point is proportional to the square root of the time involved:
that is, if it takes a particular molecule 1 second on average to go 1 um,
it will go 2 um in 4 seconds, 10 um in 100 seconds, and so on. Diffusion is
therefore an efficient way for molecules to move limited distances but an
inefficient way for molecules to move long distances.
Experiments performe... 阅读全帖
l**********1
发帖数: 5204
27
Johns Hopkins too 连tenure都过不了
不是看已有领域的挖掘 还要看新领域的digged out data and results.
please refer:
for example:
Lee Martin, Ph.D.
Professor of Pathology, Neuroscience
//pathology.jhu.edu/department/divisions/neuropathology/faculty-staff.cfm
his group recent paper:
线粒体上的控制 NO 的通道控制着细胞老化和自然死亡的过程
"The mitochondrial permeability transition pore regulates nitric oxide-
mediated apoptosis of neurons induced by target deprivation.” (2011)
J Neurosci. 31: 359-370.
PubMed link:
//www.ncbi.nlm.nih.gov/pubmed/2... 阅读全帖
k****s
发帖数: 1209
28
来自主题: Biology版 - 蜕皮素
原文在
http://www.skizit.biz/2013/07/21/ecdysone-insect-hormone-an-ind
Ecdysone Insect Hormone Switches on Disease
21 Jul 2013 | ECDYSONE
MORGELLONS:
INSECT HORMONE ECDYSONE TRIGGERS GENETIC CHANGES
TO BUILD NEW HAIR, SKIN, NAILS and CAUSE DISEASES
SkizitGesture-2013
Morgellons is a military grade entomological terror weapon being used to
torture and kill innocent civilians. The medical community has not been
informed about this disease and its complexity keeps it from being properly
identified, ... 阅读全帖
P*****e
发帖数: 25
29
来自主题: Biology版 - 比较一下CRISPR专利内容
今天有空去查了一下CRISPR专利的历史,UCB的专利已经有claim通过了审查(allow)
,只是还没有issue(时间问题)。我在后面列出来了其中一个通过了的claim,同时把
张锋issue了的专利里面的一个claim也列了出来。大家看能避开不?张锋后来的Cpf1看
着能避开UCB的Cas9。
有意思的是发现最早的一篇CRISPR相关专利申请其实是Luciano A. Marraffini(张锋
合作者)在Northwestern University时申请的,priority date Sep 23, 2008,早了
好几年。看看claim,只有interference,还没进化到切割,可惜一个claim也没批,居
然华丽丽的被一堆112给毙了,也就是审查员觉得那专利写的不清不楚,业内普通人士
看着不可能做出claim的结果,连101,102,103都没用上就挂了。西北也是早早的
abandon了,当年连PCT都没申请,可见并不重视。张锋专利里也没有Marraffini,虽然
science文章有他,我猜可能也是他只做真核interference方面的工作吧,张跟他合作
并进... 阅读全帖
x******0
发帖数: 1490
30
【 以下文字转载自 Statistics 讨论区 】
发信人: xzxz0000 (凶涨凶涨), 信区: Statistics
标 题: R 编程面试题,被弄残废了,在这里求解,钱不多,但会鼎力散财,
发信站: BBS 未名空间站 (Sat Apr 14 20:21:09 2012, 美东)
面试了一个software职位,本以为很有戏,但考我的题基本上全是job description上
没有的R 编程,希望这里的大侠帮助解惑答疑,在下感恩不尽。
1)
An analytical technique used in a molecular biology lab involves dispensing
solutions of DNA in very
low concentration into 384-well plates. Consider the perfectly random
distribution of N=30 molecules
onto this device
a) What is the probability that two molecules fall... 阅读全帖
k*****1
发帖数: 454
31
针对你现在说的几点
1.“H-H原文明确区分了”supposed“”charged molecule",和运载离子电流的"
sodium"
.波尔兹曼定律描述的是前者,不是后者。而你的原贴中让人误解为后者,跟贴中更是
强调了这一点。这是不符合作者原意的。”
这点你的意见是对的。我应该先说明一下,免得后面人误会。
“2.你说H-H的设想中,带电分子(原文可没有说是载体,请不要乱翻译)要运动到膜外
是不对的。“他们明确说了是"on the inside/outside of membrane",以及"
neglectable concentrations elsewhere".同时如果带电分子如果可以脱离膜的话,他
们用波尔兹曼的公式就不对了。因为电场只存在跨膜区域中。如果他们用的真是载体这
个词,就更
不可能脱离膜了。”
你看这句:“Since both combined and uncombined carrier molecules bear a
negative charge they are attracted to the outside of the membrane in ... 阅读全帖

发帖数: 1
32
1) I have no comments, but Dr. Chou has mentioned he was able to reproduce
it.
2) DNA band and migration are easily alternated by sample ionic strength and
buffer. The reason lies in the mechanism of DNA molecule electrophoresis is
so different from SDS-PAGE. DNA band shift is not a unusual result if DNA
sample denature or conformation is not consistent because DNA molecules
migrates on a electrical filed by the negative charge of its own phosphate
groups of which the charge is easily altered by... 阅读全帖

发帖数: 1
33
读了一下这篇文章,不喜欢这种研究思路,不能够称之为科学。
该实验室主页上面所挂出来的以下一些文章中,有很多引用率非常的低。
ROCKII inhibition promotes the maturation of human pancreatic beta-like
cells. Nature Communications. 2017 Academic Article GET IT
High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates
that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain.
Cell Stem Cell. 2017 Academic Article GET IT
A Modular Platform for Differentiation of Human PSCs into All Major
Ectodermal Lineages. Cell Stem Cell. ... 阅读全帖
c**m
发帖数: 757
34
来自主题: Chemistry版 - two positions in bay area
Flexus Biosciences
Position Title
Medicinal Chemistry Scientist (Permanent and Temporary Positions
Available)
Job Description
Design and independently synthesize novel molecules directed at one or
more of our biological targets. Integrate large amounts of data on
previously synthesized molecules into the design of novel molecules
anticipated to possess increasingly optimal biological profiles. Participate
in identification of novel drug candidates and their advancement into
clinical eval... 阅读全帖
i**********d
发帖数: 853
35
来自主题: MedicalCareer版 - 有1道NBME题请教前辈高人
谢谢回复,我之所以问这个问题是因为:从外来抗原被注射入体内,到APC细胞把它和
MHC II的complex表达在细胞膜上之间有一些复杂的步骤,我个人认为这中间的过程是
解释这个题的关键所在。
基本步骤:
1. Exogenous antigens, such as viruses, are engulfed and placed in a
phagosome.
2. Lysosomes fuse with the phagosome forming a phagolysosome.
3. Protein antigens are degraded into a series of peptides.
4. MHC-II molecules are randomly synthesized in the endoplasmic reticulum;
since MHC is very complicated system and can form numerous different MHC II
molecules, in most time at least one MHC II ... 阅读全帖
x******0
发帖数: 1490
36
面试了一个software职位,本以为很有戏,但考我的题基本上全是job description上
没有的R 编程,希望这里的大侠帮助解惑答疑,在下感恩不尽。
1)
An analytical technique used in a molecular biology lab involves dispensing
solutions of DNA in very
low concentration into 384-well plates. Consider the perfectly random
distribution of N=30 molecules
onto this device
a) What is the probability that two molecules fall in the same well? Derive
the closed-form
equation for this probability.
b) Plot the above expression for the probability as a function of the numbe... 阅读全帖
s********n
发帖数: 2939
37
来自主题: Military版 - 普鲁士蓝解毒机理
为什么一帮人就喜欢动嘴皮子不喜欢动手狗一下?明明说了是Fe4[Fe(CN)6]3,哪来的
钾?
https://en.wikipedia.org/wiki/Prussian_blue
Prussian blue
From Wikipedia, the free encyclopedia
This article is about the pigment. For the musical duo, see Prussian Blue.
See also: Midnight blue
Prussian blue
IUPAC name[hide]
Iron(II,III) hexacyanoferrate(II,III)
Other names[hide]
Berlin blue
Ferric ferrocyanide
Ferric hexacyanoferrate
Iron(III) ferrocyanide
Iron(III) hexacyanoferrate(II)
Parisian blue
Identifiers
CAS number 14038-43-8
PubChem ... 阅读全帖
l********k
发帖数: 14844
38
STORM的关键,除了这个荧光分子轮着闪、单个定位这个方法上的技巧之外,最最最关
键的是switchable dye. 只要掌握了这个东西,STORM也好,PALM也好,高中生、甚至
初中生都可以理解原理,甚至原创出来。庄小威是化学出身,之前研究的一个方向也正
是这个switchable dye, 比如她在2005年的这篇论文(STORM, PALM都是06年的工作):
Short-Range Spectroscopic Ruler Based on a Single-Molecule Optical Switch,
Phys. Rev. Lett. 94, 108101 – Published 15 March 2005
有了这个东西,基本上距离STORM只有一步之遥了。
但是很难说,当时庄脑子里有STORM这个金矿,尽管她就踩在金矿上面。她做
switchable dye/protein这个工作,也不是她开创的领域。在此之前,用光来控制分子
构型、改变光学特性的工作已经开展了很长时间(至少10年),比如
On/off blinking and switching behaviour... 阅读全帖
A********e
发帖数: 354
39
【 以下文字转载自 Biology 讨论区 】
发信人: albertsmwk (.)(.), 信区: Biology
标 题: 第一批“青年千人计划”生物类@publication列表@
发信站: BBS 未名空间站 (Thu Aug 18 15:04:16 2011, 美东)
花了一个小时,深深的鄙视一下自己的无聊行径!!
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branche... 阅读全帖
g******h
发帖数: 101
40
来自主题: Postdoc版 - Postdoc Position: Analytical Chemstry
http://chemistryjobs.acs.org/jobs#/detail/5305585/1,false
Job Summary
Research Associate / Assay Development POSTED: Apr 04
Salary: $ 35,000.00 - 45,000.00 Location: East Lansing , Michigan
Employer: Michigan State University Type: Full Time - Experienced
Field of Specialization: Analytical Work Function: Quality Control/
Analysis, Research-Applied
Required Education: Doctorate

We seek an analytical/organic/medicinal chemist to develop assays to measure
... 阅读全帖
p*******g
发帖数: 2976
41
【 以下文字转载自 Biology 讨论区 】
发信人: albertsmwk (.)(.), 信区: Biology
标 题: 第一批“青年千人计划”生物类@publication列表@
发信站: BBS 未名空间站 (Thu Aug 18 15:04:16 2011, 美东)
花了一个小时,深深的鄙视一下自己的无聊行径!!
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branche... 阅读全帖
O***n
发帖数: 13127
42
【 以下文字转载自 Biology 讨论区 】
发信人: albertsmwk (.)(.), 信区: Biology
标 题: 第一批“青年千人计划”生物类@publication列表@
发信站: BBS 未名空间站 (Thu Aug 18 15:04:16 2011, 美东)
花了一个小时,深深的鄙视一下自己的无聊行径!!
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branche... 阅读全帖
s******t
发帖数: 96
43
来自主题: loseweight版 - 关于GI一个小小的疑问
one molecule 蔗糖可分解为 two molecules glucose
one molecule 果糖可分解为 one molecule glucose + one molecule fructose
血糖=glucose
so 果糖对血糖升高贡献较少
f**********r
发帖数: 18251
44
来自主题: WaterWorld版 - Re: 普鲁士蓝解毒机理 (转载)
【 以下文字转载自 Military 讨论区 】
发信人: smartkevin (PE), 信区: Military
标 题: Re: 普鲁士蓝解毒机理
发信站: BBS 未名空间站 (Wed May 1 11:49:11 2013, 美东)
为什么一帮人就喜欢动嘴皮子不喜欢动手狗一下?明明说了是Fe4[Fe(CN)6]3,哪来的
钾?
https://en.wikipedia.org/wiki/Prussian_blue
Prussian blue
From Wikipedia, the free encyclopedia
This article is about the pigment. For the musical duo, see Prussian Blue.
See also: Midnight blue
Prussian blue
IUPAC name[hide]
Iron(II,III) hexacyanoferrate(II,III)
Other names[hide]
Berlin blue
Ferric ferrocyanide
Ferric hexacy... 阅读全帖
R******d
发帖数: 5739
45
来自主题: Belief版 - 进化论的错误假设 (转载)

了。
before you comment on science, you should at least have some education in
science. otherwise it is foolish to comment, and it might be foolish for me
to answer you if you don't read more.
-------------------
进化论者基本错误就是其假设,一切假设都是根据人自己的思维来考虑的。如果按照自
然界逻辑来考虑的话,那么试问
1 无机物为何一定要变有机物?事实是有机物最后腐败分解都变成了无机物,有机物也
无法在太阳或其他星球生存。有机物无法适应恶劣环境且很脆弱,为何进化论假设反了。
----------------------------
inorganic or organic are just two categories of morelecules categorized by
chemists. categorizing them is not relevant to w... 阅读全帖
E*****m
发帖数: 25615
46
来自主题: TrustInJesus版 - 再聊进化论:第一个蛋白质
這個其實也是老問題了,都已經整理編號了
http://www.talkorigins.org/indexcc/CB/CB010.html
Claim CB010:
The proteins necessary for life are very complex. The odds of even one
simple protein molecule forming by chance are 1 in 10113, and thousands of
different proteins are needed to form life. (See also Primitive cells
arising by chance.)
Source:
Watchtower Bible and Tract Society. 1985. Life--How Did It Get Here?
Brooklyn, NY, pg. 44.
Response:
The calculation of odds assumes that the protein molecule formed by
c... 阅读全帖
j**********i
发帖数: 3758
47
有一场像 stem cell一样的大讨论,不过要去联合国吵。
Using an artificial intelligence technique inspired by theories about how
the brain recognizes patterns, technology companies are reporting startling
gains in fields as diverse as computer vision, speech recognition and the
identification of promising new molecules for designing drugs.
Connect With Us on Social Media
@nytimesscience on Twitter.
Science Reporters and Editors on Twitter
Like the science desk on Facebook.
Keith Penner
A student team led by the compute... 阅读全帖
n********k
发帖数: 2818
48
As you folks are discussing Cori, I happened to read his autobiography and
find it both interesting and enlightening:)))...BTW, it sounds Richard Axel
is a lot nicer than what I/we have heard...or in another word, his cruelty
is rooted in his obsession with science and indifference to humanity:))); As
well, it is pretty...he noted Cori but left his ex out...pretty human or
not human?
Autobiography
Richard AxelNew York City is my world. I was born in Brooklyn, the first
child of immigrant parents... 阅读全帖
a********k
发帖数: 2273
49
花了一个小时,深深的鄙视一下自己的无聊行径!!
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branches in lamellipodia. Cell. 2008 Sep
5;134(5):828-42. PubMed PMID: 18775315; PubMed Central PMCID: PMC2570342.
Cai L, Makhov AM, Bear JE. F-actin... 阅读全帖
z*t
发帖数: 863
50
Beutler得奖,Medzhitov会不会有意见?
http://www.sciencedirect.com/science/article/pii/S1074761309002
Ruslan Medzhitov
This year marks the 20th anniversary of a publication (Janeway, 1989) that
in many ways revolutionized our understanding of the immune system. As part
of the proceedings of the Cold Spring Harbor Symposium on Immune Recognition
, the paper authored by the late Charles A. Janeway, Jr. was not a standard
peer-reviewed publication. In fact, Charlie used to refer to it as “the
best paper I've ... 阅读全帖
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