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全部话题 - 话题: molecule
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h*********r
发帖数: 10182
1
来自主题: Tennis版 - 打网球真减肥
wiki说phosphorus是所有cell的必须的
Phosphorus is a key element in all known forms of life. Inorganic phosphorus
in the form of the phosphate PO43– plays a major role in biological
molecules such as DNA and RNA where it forms part of the structural
framework of these molecules. Living cells also use phosphate to transport
cellular energy in the form of adenosine triphosphate (ATP). Nearly every
cellular process that uses energy obtains it in the form of ATP. ATP is also
important for phosphorylation, a k
W********m
发帖数: 7793
2
来自主题: TexasHoldem版 - Elements of poker (129)
129. The Path of Least Resistance
There’s good resistance and bad resistance. When we resist harming
ourselves and others, that’s the good kind. When we resist reality,
that’s the bad kind. What we want to do then is apply the good
kind of resistance to the bad kind, and resist resistance.
What does it mean to resist reality? It means to wish things are
different than they are. The sequence of events goes like this. First,
we experience reality with our senses. We see, hear, touch, smell, and ta... 阅读全帖
l*****o
发帖数: 19653
3
看看这篇文章吧(放狗搜的):
http://www.economist.com/node/21548151
QUANTUM effects are vital to modern electronics. They can also be a damnable
nuisance. Make a transistor too small, for example, and electrons within it
can simply vanish from one place and reappear in another because their
location is quantumly indeterminate. Currents thus leak away, and signals
are degraded.
Other people, though, see opportunity instead. Some of the weird things that
go on at the quantum scale afford the possibility of doin... 阅读全帖
h**********l
发帖数: 148
4
来自主题: MusicPlayer版 - 请辞乐手版版副 (转载)
I think cherry was totally lei-ed by our wsn at the board gathering event.
It is not our fault to be ws, but we should not come out to lei cherry and
let her down. I feel deeply sorry to be one of the ws molecules. Other ws
molecules say sorry after me.
n*********0
发帖数: 1543
5
来自主题: WaterWorld版 - 请理性对待中医的存在
Dopamine.
Serotonin.
Noradrenalin.
These three neural transmitter are so called happy messengers. They bind to
their corresponding receptors and generate nerve impulses at specific region
in the brain and leads to sensation of happiness.
A lot illegal drugs mimics the structure of these neural transmitters and
can cause euphoria. Since the sensation is so amazing (even stronger than
orgasm), they are highly addictive.
The electric signal of vision starts when photon hit the retina which has
cell... 阅读全帖
t******n
发帖数: 2939
6
来自主题: WaterWorld版 - [合集] 请理性对待中医的存在
☆─────────────────────────────────────☆
junlver (junlver) 于 h 提到:
你去美国书店,不可否认的一点是,医药书架上基本都会有一栏放着非传统治疗书
籍。其中有很多是介绍关于中草药的功能和使用。很多不是照搬照抄的中医古籍翻译本
,是经过加工整理的。看看美国人对中医的态度,那是相当认真的。
西医有个最大的优点就是不管什么,只要有疗效,那就是好的,就是科学的。就是
不科学,那我也要拿出科学的统计数据,让他科学化。不知反对中医的人知道
Echinacea不?这个Echinacea中文名叫紫锥菊,虽然包含china但和中国没啥关系。这
可是欧美很常见的一种花。你家邻居家可能就种了!主要功能不用我说,自己查。我想
说的是,欧美人一样用草药。知道Astragalus么?对的,是黄芪。欧美人很喜欢用这两
个药混在一起用于对抗病毒感冒。中国的烂树根和鲜花可以治感冒!欧美也有秘方治感
冒。别以为感冒只能喝水,那是医生敷衍你。虽然很多疾病可以自愈,但是谁不希望症
状尽快减轻和治愈?要不然西医也没必要研发感冒药了。
中... 阅读全帖
f*******e
发帖数: 2791
7
来自主题: WaterWorld版 - 方舟子美国专利真相调查(ZT)
本帖最后由 jshi6210 于 2010-7-13 11:58 编辑
方舟子美国专利真相调查(ZT)
万维读者网络>教育与学术
美国永久居民、所谓“打假斗士”方舟子常常在中美之间飞来飞去,他经营的美国网站
新语丝,据说每天点击五六十万。他何以为生、维持网站运营,是长期以来大家比较感
兴趣的一个问题。今天因为甘怀远同学的揭露,进行了一番饶有趣味的搜索。
1. 方舟子的博士后在索尔克生物研究院进行 方舟子,本名方是民,1967年9月生于
福建云霄县。1985年考入中国科技大学生物系。1990年本科毕业后赴美留学。1995年获
美国密歇根州立(Michigan State)大学生物化学博士学位,先后在罗切斯特(
Rochester)大学生物系、索尔克(Salk)生物研究院做博士后 …
scitech.people.com.cn/GB/25509/43690/index.html
2. 方舟子本人如此解释他的收入来源 方舟子:我把博士后研究时做的东西(克隆
了一个基因)申请了专利,得到一笔钱,可以维持基本生活费用。同时,我与人合作在
国内开了个专... 阅读全帖
b******r
发帖数: 251
8
It is because that the balloon is made of rubber, which is permeable to the
gas molecules inside. Therefore, no matter how tight you seal the end of the
balloon, gas molecules will permeate through the thin rubber wall from the
interior of the balloon over time and it will look like that the balloon is
"跑气".
The permeation through the rubber wall is a slow process and therefore you
will not observe the "跑气" until you wait for a sufficiently long time. The
time will depend on the material and thi... 阅读全帖
h********m
发帖数: 14
9
请帮忙转求医问药版和我爱宝宝版
我孩子今年5岁3个月,男孩。出生于东海岸,一直在东海岸生活到1岁搬到西海岸。2岁
开始出现了一系列的症状,开始突然半夜腹痛,后来便秘超过2个星期,再后来出现便
秘,腹泻,腹胀等各种症状交替发生。
在过去的3年多已经,已经进行了一系列的therapy (speech, OT, ABA等)基本无效。
也尝试了各种diet,GFCF,SCD,FODmap等,基本没解决问题,biocidin,
Saccharomyces boulardii 有一点效果(但有限)。无克罗病家族史。
他最主要的一个症状就是肚子的气非常的多,腹胀。早上起床的时候肚子是非常的小 (
正常的),后来就越来越大,一直大到好像带了一个大气球!!!!
我们进行了很多的测试,在美国正规的儿科儿童医院基本没查出问题。我们查了无数的
资料,也基本没发现什么跟他相似的小孩。现在抱着最后一丝希望上Mit来问一下,希
望能得到一点信息。如果大家都听说过类似案例,或者有肠胃科医生给点意见,又或者
有不错的医生推荐,都非常感谢!
最近我们又看了一个小儿肠胃专科,初步诊断是回肠炎,据说绝大部分的回肠炎都属于
C... 阅读全帖
I*****a
发帖数: 5425
10
【 以下文字转载自 Biology 讨论区 】
发信人: qianluludna (luluqian), 信区: Biology
标 题: 2013诺贝尔医学生理学奖和施一公擦肩而过zz
发信站: BBS 未名空间站 (Mon Oct 7 12:54:16 2013, 美东)
联合授予:
詹姆斯/洛斯曼(James E. Rothman),兰迪 舍克曼(Randy W. Schekman),和 汤姆
斯 苏霍夫(Thomas C. Südhof),
贡献是:发现了细胞中一种主要传输系统,打包运输的机械调控。
"for their discoveries of machinery regulating vesicle traffic, a major
transport system in our cells".
部分解说词是:
三位科学家揭示了细胞内部输运系统组织的神秘性。每一个细胞就是一个生产和出口分
子的工厂,这些分子在细胞内输运。运输过程这些分子打包成为vesicles(小泡,囊泡
)。三位获奖人发现了控制这些准时准确货运系统的分子控制机制。
Summary
The 2013... 阅读全帖
H********g
发帖数: 43926
11
嗯,看起来1飞秒的确还不算很短。那再短1000倍,是啥效果?要短到什么程度,电子
会不是云?电子到底会不会不是云?
1.3 fs – cycle time for 390 nanometer light, at the transition between
violet visible light and ultraviolet[5]
2.57 fs – cycle time for 770 nanometer light, at the transition between red
visible light and near-infrared[5]
15 fs – the swiftest chemical reaction, such as the absorption of a light
photon in the Photosynthetic antenna molecule
200 fs – the average chemical reaction, such as the reaction of pigments in
an eye to light[5]
300 f... 阅读全帖
z*********n
发帖数: 94654
12
来自主题: Joke版 - 猪油又被正名了
google is lard healthy
We're not going to make any health claims about lard -- because what do we
Taste editors know about health? -- but we can report what we've learned:
lard has 20 percent less saturated fat than butter; it's higher in
monounsaturated fats which are said to lower LDL cholesterol; and it has
none of the trans ...
头条hit:
Lard is healthy!
In recent generations, lard has seemed to completely disappear from home
kitchens. Until the early 1900’s, lard was a staple cooking fat acros... 阅读全帖
H********g
发帖数: 43926
13
细菌通常一个,古生菌(跟细菌有很多不同的原核生物)可以有多个。
Most bacteria have a single circular molecule of DNA, and typically only a
single origin of replication per circular chromosome.[3]
Most archaea have a single circular molecule of DNA, and several origins of
replication along this circular chromosome.[4]
r*s
发帖数: 2555
14
来自主题: Joke版 - 诺委会太不像话了
尼玛87篇参考文献就不能加一篇施教授或能教授的CNS?
References
1. Ruska, E., Nobel Lectures, Physics 1981-1990, Tore Frängsmyr and
Gösta Ekspong, Eds. (1993) World Scientific Publishing, Singapore
2. Marton, L. (1934) Electron microscopy of biological objects. Nature
133, 911-911
3. Althoff, T., Mills, D. J., Popot, J. L., and Kühlbrandt, W. (2011)
Arrangement of electron transport chain components in bovine mitochondrial
supercomplex I1III2IV1. The EMBO Journal 30, 4652-4664
4. Letts, J. A., Fied... 阅读全帖
B********e
发帖数: 19317
15
来自主题: Belief版 - 大家来学习,进化论101
http://evolution.berkeley.edu/evolibrary/article/side_0_0/origsoflife_04

How did life originate?
Living things (even ancient organisms like bacteria) are enormously complex.
However, all this complexity did not leap fully-formed from the primordial
soup. Instead life almost certainly originated in a series of small steps,
each building upon the complexity that evolved previously:
1. Simple organic molecules were formed.
Simple organic molecules, similar to the nucleotide shown belo
R******d
发帖数: 5739
16
来自主题: Belief版 - 进化论的错误假设 (转载)

------------------
diamond is one example of free energy stored in a metastable state. you
wanted an example of non biological example of non spontaneous one and there
it is. now you are asking a non biological example but related to
biological system? well the relation would be that metastable states occurs
in the nature whether biological or not.
---------------------------
SINGLE : biologically active molecule could even possibly be made from
inorganic
------------------------------
one d... 阅读全帖
c****t
发帖数: 19049
17
An international team of scientists says it's figured out how to slow global
warming in the short run and prevent millions of deaths from dirty air:
Stop focusing so much on carbon dioxide.
They say the key is to reduce emissions of two powerful and fast-acting
causes of global warming — methane and soot.
Carbon dioxide is the chief greenhouse gas and the one world leaders have
spent the most time talking about controlling. Scientists say carbon dioxide
from fossil fuels like coal and oil is a b... 阅读全帖
l**********t
发帖数: 5754
18
来自主题: TrustInJesus版 - 一个历史两种可能性:闲聊进化论

the very basic building block (organic molecules such as AA) can be
generated from inorganic molecules in simulated prehistoric environments.
neither. Creating living creature (or just functional enzyme) from organic
soup have not been achieved via "natrual process" in any lab.
进化论 claims to be "science" so it is subject to the criteria of "science".
Whatever can not be proven shall be stated as assumptions. Unfortunately
layman would accept the conclusion from the scientists w/o pay
attentio... 阅读全帖
l**********t
发帖数: 5754
19
来自主题: TrustInJesus版 - 进化与进化
:【 在 Eloihim (真神) 的大作中提到: 】
::【 在 littletshirt (AUG) 的大作中提到: 】
:: so follow your logic, you can trace the "biological parent" (grandparent)
of
:: chichen all the way back to single celled organism,
:yes
::and then back to
:: inorganic molecules thru abiogenesis, right?
:not sure about this part .
--why? Because of the lack of scientific support for abiogenesis, or because
of your philosophic distinction between living vs. nonliving?
back to your question - 第一個男人? 沒有生物父母的?
although I don't aggre... 阅读全帖
h***s
发帖数: 1716
20
来自主题: Wisdom版 - 我发个善心,说句公道话
这个今年5月有NATURE上的一篇关于电子形状的的最新实验进展和报道. 况且这是人成
千上万没有搞M理论的实验物理学家的真刀真枪干出的事, 不关他们美丽的绳子和M理论
什么事.
Improved measurement of the shape of the electron
http://www.nature.com/nature/journal/v473/n7348/full/nature1010
Improved measurement of the shape of the electron
J. J. Hudson,1 D. M. Kara,1 I. J. Smallman,1 B. E. Sauer,1 M. R. Tarbutt1 &
E. A. Hinds1
AffiliationsContributionsCorresponding author Journal name:
Nature
Volume:
473,
Pages:
493–496
Date published:
(26 May 2011)
DOI:
doi:10.1038/nature10104
Rece... 阅读全帖
Y**u
发帖数: 5466
21
☆─────────────────────────────────────☆
heyes (hoooyou) 于 (Fri Aug 12 13:21:56 2011, 美东) 提到:
佛就是佛,道就是道,是修生养性,和人生和哲学扯扯还行。
不要再和什么爱因斯坦,量子力学,薛定谔猫啊狗的瞎联系了,好不好?再这么下去,
你们要把人类所有的光辉成果都给吞食到佛的肚子里了,还怎么个这个空空,那个空的
呢?这种文章都mark实在太。。。佛告诉我,沉默是真空。所以我就不沉默了。
如果你们硬要扯人类的光辉思想是佛早就知道的,我来问你们那些自以为懂猫啊狗的一
个问题。回答这个问题不是你们那种马后炮就可以蒙混过去的,要真刀真枪干的。
哦,老爱已经做了相对论了,你们偷过来这么一说,就成佛的“预见”了?人物理学家
辛辛苦苦几代搞的量子力学,你这一猫啊狗的一吹,就又成佛“早就知道”的了?蛋不
是这么扯的,慧根不是这么修炼的吧?
好吧,问题来了,很简单。
“请问人能不能回到(时间)的过去?”
请给出佛的答案,看看佛会不会早已经预料到了物理学家的“光辉思想”(以后或者将
来,或者佛说没有过去,现在和未... 阅读全帖
R*****N
发帖数: 217
22
来自主题: BMU版 - 大家好
不好意思,刚才差点断了,现在报道继续...
这些日子,molecule都在医院里忙着挣钱,给那些狗屁不通的家伙们打工,另外就
是替老板
写下学期上课用的幻灯片,苦啊,在这里就是做牛做马的份!所以我把气都撒在研究生
身上,这
些家伙也不争气,做实验的时候什么错误都能犯,昨天居然打翻了溴乙锭,吓得molecu
le一直
跑到延安路上才松了口气...
关于明明的秘密,其实大家都知道,不必在这里大呼小叫了吧,嘿嘿。molecule还
是个
老光棍,一天到晚在bbs上装大尾巴狼,也没有mm上钩,倒是认识了不少ggdd,都是清一

的光棍,是啊,有mm的哪有这么多时间来爬bbs啊?
不多说了,大家都好吧?我9月开学。
对了,现在米国的mp3man多少钱一个?要64M的,我有个朋友下个月来米国公干,我
想让他
顺便带一个的说,thanks!
c*******l
发帖数: 158
23
未来是那么的美好。到时候学化工的又可以去搞氢气啊之类。问题是,那是22世纪的事
情。
在今天,化工,材料的学者就只能到处讨饭,求生存。被外校的,被本校的人在白眼,
看笑话。
希望50年以后,那时的年轻人能回来看一眼当初的前辈,在为他们的幸福生活,毁灭了
自己去铺路啊。不管是搞氢气的,还是用氢气的,比如fuel cell。
当然这是不可能的了。
就跟混大药厂做合成的,估计从来没人去仔细想过当初那些混post-doc找出molecule的
基础科学研究者。都是感觉自己牛B。问题是没他们发现molecule,你倒是合成个屁啊。
g***2
发帖数: 403
24
http://www.sciencemag.org/cgi/content/abstract/328/5980/882
Hydrogen Bonding Controls the Dynamics of Catechol Adsorbed on a TiO2(110)
Surface
Shao-Chun Li,1,* Li-Na Chu,2 Xue-Qing Gong,2 Ulrike Diebold1,3,*
Direct studies of how organic molecules diffuse on metal oxide surfaces can
provide insights into catalysis and molecular assembly processes. We studied
individual catechol molecules, C6H4(OH)2, on a rutile TiO2(110) surface
with scanning tunneling microscopy. Surface hydroxyls enhanced the
O*****c
发帖数: 679
25
来自主题: ECUST版 - 急报田禾当选2011科学院院士
你讲的是对的。华理搞api,那是出手就能赢。华理有化工,有工业分析,都是全国第
一的学科。
但是,华理没有能搞全合成的人。这个本来可以引进的。搞合成都是些北大之类的。来
美国去的都是harvard之类的地方。
所以,华理毕业的,很多都是做med-chem什么的。不是做全合成的。就是加州有种小公
司,都是等着被卖的命。就是从什么地方花钱买个molecule,搞个compound做骨架。然
后这接一个集团,那搞一个集团。合成出一堆垃圾。然后就是去试验什么的。然后有苗
头再一女多嫁。这个modified molecule卖给GSK。那个卖个pfe。结果就是什么me too
之类的东西。
他们有混这种美国公司的学生。因为全合成华理毕业的有谁能搞的?所以就惦记着搞那
种公司。将来有外包。然后有收入,最后能上市之类的。就是搞个很小的上市公司。属
于创业板那种。然后自己抽头走人。
从他们自己学科看,全对的。他们甩掉其他学科,照样可以接外包。也不用引进人才分
赃。而且投资少,战线短。都是些实验室的瓶子。搞api投资大很多了。而且他们算什
么,什么都不算。
从华理看,那怎么说哪?
所以说这次华理谁当校长... 阅读全帖
o*****s
发帖数: 1445
26
small molecule is dead. Nowadays, it works in this way:
A company develops a bunch of potential candidates.
B company buys some and do clinic trial.
B ask C company to support, e.g., synthesis in Kg Lab (make API no more than
1 Kg or 22 L of glass ware), do some analycal work.
After the drug candidate passed phase II, they sell it to a large company D,
e.g., pfizer.
D usually build up a division in China, say, API manufacturing facility, and
corresponding R&D.
From A to C, each company usually h... 阅读全帖
o*****s
发帖数: 1445
27
small molecule is dead. Nowadays, it works in this way:
A company develops a bunch of potential candidates.
B company buys some and do clinic trial.
B ask C company to support, e.g., synthesis in Kg Lab (make API no more than
1 Kg or 22 L of glass ware), do some analycal work.
After the drug candidate passed phase II, they sell it to a large company D,
e.g., pfizer.
D usually build up a division in China, say, API manufacturing facility, and
corresponding R&D.
From A to C, each company usually h... 阅读全帖
j****u
发帖数: 1413
28
2015年8月22日,波士顿科大校友会将举办首次医药行业的校友沙龙聚会。我们邀请到
了波士顿医药界三位资深校友陈寅(808),金晓玮(843) 和李劲波(863)为我们做嘉宾演
讲,纵论中美医药行业发展的机遇和挑战并分享作为科大校友在医药行业发展的心得体
会。欢迎中国科大校友参加,一同欢聚在查尔斯河河畔!
通知网址:http://ustcbaa.com/events/%E6%B3%A2%E5%A3%AB%E9%A1%BF%E4%B8%AD%E5%9B%BD%E7%A7%91%E5%A4%A7%E6%A0%A1%E5%8F%8B%E6%91%86%E4%B8%8B%E9%BE%99%E9%97%A8%E9%98%B5%E5%A4%A7%E8%AF%9D%E5%8C%BB%E8%8D%AF%E5%88%9B%E6%96%B0%E9%A2%86%E5%9F%9F/
时间: 2015年8月22日14:00-16:00
地点:220 Longwood Ave, Boston, MA。 教室 Goldenson 122, Harvard Medical
School(周围停车较不便, 可乘坐绿线... 阅读全帖
A***l
发帖数: 302
29
来自主题: XMU版 - Combinatorial libraries
1. Identification of antigenic determinant peptides and synthetic peptide
combinatorial libraries
Since peptide vaccines must contain B-cell/T-cell recognized epitopes, it is
crucial to identify them. So far several methods have been used to identify
such epitopes. If the amino acid sequence of a protein antigen is known,
overlapping peptides can be synthesized and screened as targets for B cells,
MHC class I molecules/CTL cells (typically 8-10 amino acids) and MHC II
molecules/helper T cells (t
n*******y
发帖数: 10
30
来自主题: XMU版 - Carbon-50 makes its debut
Is it the first Science paper from XMU? (First Author and corresponding
author)
Physical chemists in China have made carbon-50 molecules in the solid state
for the first time. Lan-Sun Zheng and colleagues at Xiamen University, and
co-workers at the Chinese Academy of Sciences in Beijing and Wuhan, prepared
the molecules - which they describe as a long sought little sister of
carbon-60 - in an arc-discharge technique involving chlorine. The result will
allow scientists to study the properties of
i****x
发帖数: 17565
31
来自主题: Hardware版 - 5Ghz是不是比2。4ghz的辐射更强?
懒得跟民科废话了,自己读去吧。
http://en.wikipedia.org/wiki/Ionizing_radiation
Ionizing (or ionising) radiation is radiation that carries enough energy to
liberate electrons from atoms or molecules, thereby ionizing them. Ionizing
radiation comprises subatomic particles, ions or atoms moving at
relativistic speeds, and electromagnetic waves on the short wavelength end
of the electromagnetic spectrum. Gamma rays, X-rays, and the upper vacuum
ultraviolet part of the ultraviolet spectrum are ionizing, whereas the... 阅读全帖
j****i
发帖数: 305
32
来自主题: Programming版 - C++ design problem
I have the following classes: Atom, Molecule (contains atoms). I also have
the CoordinatedAtom class
which derives from Atom and contains position information. My
CoordinatedMolecule class should derive
from Molecule, but needs to contain CoordinatedAtom, instead of Atom. How
should I write the
CoordinatedMolecule class? I think this might be a common design problem.
What I'm thinking is that
whether I could define a member variable in CoordinatedMolecule that has the
same name as the base
class
D*******a
发帖数: 3688
33
来自主题: Programming版 - C++ design problem
use template
Molecule
Molecule

the
s*****t
发帖数: 1994
34
Aurora Over Clouds
Credit & Copyright: Dominic Cantin
Explanation: Aurorae usually occur high above the clouds. The auroral glow is created when fast-moving
particles ejected from the Sun impact air molecules high in the Earth's atmosphere. An oxygen molecule, for
example, will glow in a green light when reacquiring an electron lost during a collision with a solar particle. The
lowest part of an aurora will typically occur at 100 kilometers up, while most clouds usually
j***l
发帖数: 100
35
来自主题: Biology版 - Math/Systems/Synthetic Biology 人物榜
zesta三年后的文章同样很精彩! 江山代有才人出,各领风骚数几年;系统生物领域的浮沉
如同在招摇它的蓬勃发展;此间似乎不只是埋头苦干就可以站住脚的,新的想法更能带
来生机。
这里补充几个刚刚拿到位置的小牛们,看看他们能否后来居上
1)Stanford:
KC Huang, MIT理论凝聚态毕业,博后开始转生物,跟Princeton的Ned Wingreen做cell
shape,原来做纯计算的,现在自己的lab也开始做实验了.
Jan Skotheim,数学起家,MIT本科,剑桥博士,博后到Rockefeller跟两个cell cycle
的大牛Eric Siggia和Fred Cross.
2)MIT:
Jeff Gore和Long Cai, 两人都是名副其实的paper printer. 前者似乎非Nature不发,
个人认为Jeff有创新的天赋,从single molecular的Carlos Bustamante实验组出来就
加入van Oudenaarden的systems biology.那篇微生物的game theory听来很新颖,发出
去更是不费吹灰之力。Long和J... 阅读全帖
D******n
发帖数: 2836
36
my friend wants to attach a biotin molecule to a lysine of protein and then
do some energy minimization.
I managed to add the molecule in pymol, but probably it is not in its favora
ble conformation. Anyone can suggest a software to do it?
thanks
a****o
发帖数: 1786
37
来自主题: Biology版 - 第三代测序 是什么东西?
Helicossingle 是single molecule sequencing, 是NGS,还没挣钱
PacBio应该算三代, single enzyme, single molecule sequecing
c*********r
发帖数: 1312
38
来自主题: Biology版 - PacBio or SOLiD
现在的3rd gen技术还不很成熟吧,公司和产品有好多个:PacBio,LIFE,Complete
Genomics,Helicos,Ion Torrent,Oxford Nanopore,IBM。。。目前还没有一个可以
像Illumina那样的领头羊。也许等几年会明朗一些。我比较看好Helicos的技术,相当
于单分子版的Illumina吧;但不同的技术有不同的应用,比如长的reads就特别适合植
物、农作物等基因组研究,不然Monsanto也不会抢着买PacBio的仪器。
Helicos有人如是说:"I think that for the most part the world will switch
to single molecule. As to who will win, I think there will be no single
winner. Pac Bio will be the single molecule version of 454 with fewer,
longer reads. Helicos will survive either as a st
h****6
发帖数: 229
39
来自主题: Biology版 - PacBio or SOLiD
Single molecule method is promising especially with the promise of Nanopore.
Pac bio is better due to the ability to read the same molecule again, again
and again. If they can solve error rate and density issues, the future is
bright as the cost is so low. Helicose seems to be able to re-read too but
error rate is high and read length is short. Nano pore can't re-read yet.
Polinator has just been released and the instrument costs less than $50k. It
may be a good replacement of Solid. Solid is
F*Q
发帖数: 3259
40
来自主题: Biology版 - 不要八卦,来点纯学术的吧
大家来说说X-ray, NMR, Cryo-EM, Free-electron laser (或称X-ray laser) 以及
single molecule imaging等各种结构或成像技术的长短吧。
很显然X-ray好像就是高贵血统,自从诞生到目前,已经有了无数的技术上、方法上和
尤其是应用上的Nobel奖了。NMR 也拿过奖。Cryo-EM还没有真正的拿过(不包括电镜发
明奖以及最早非低温冷冻样品时代的奖),而且好像还遥遥无期。Free-electron laser
最近被热炒。single molecule imaging 近些年已经成为明星学科。
欢迎大家补充。
H*****e
发帖数: 120
41
Everytime, it is amazing to see the 3-D binding model for small molecule
binding a protein. Now I found a small molecule (a boring one!) binding a
protein (with known crystal structure). For publication purpose, I am very
interested in try to have such a model because I noticed such a computation
based modeling is publishable. Although I am not a structure person, I was
told that it can be done by computation based prediction in a seminar. I
tried google but found too many and too confusing.
c**********e
发帖数: 694
42
来自主题: Biology版 - 中药那种提取有效成分的工作
Can't agree you more. It is very difficult to discover novel bioactive
molecule nowadays.
Characterizing biosynthetic mechanism and engineering metabolic pathway of
known active products are more promising IMHO. By doing above mentioned
research, you may discover novel enzyme activities and new chemical entities
, or enable large scale production of complicated molecules (like Keasling
is using bacteria to product plant natural products).
b******d
发帖数: 149
43
来自主题: Biology版 - GPR120 Is an Omega-3 Fatty Acid Receptor

Crews
been the word to use (BS my english..||).
molecules, I
Recognitions are related, "target recognitions" will translate to
"academic recognitions"..hehe...
Indeed, "more targets could be regulated by one natural product".
Schreiber is very smart to attract top biologists (half of his lab) back
in the days.
Similar to what Deng said about cats, no matter what kind of molecule
is, synthetic or natural, it's a good one if it has cool biological
functions, even better if it could become a drug
b******d
发帖数: 149
44

known
to
vomiting.
trials
Chi
growth
Good research in a very exciting field: studying natural products and
small molecules, chemical biology and proteomics.
This type of research is kind of opposite to the traditional biomedical
research. It usually starts with some natural products or small
molecules with very interesting known phenotypes, but very little
knowledge of mechanisms and targets. The ultimate research goal is to
find mechanisms and targets. No matter what mechanisms and targets
J********n
发帖数: 534
45
来自主题: Biology版 - 到底为什么要做结构?
其实protein crystallography的原理和显微镜的道理是一模一样的。
"But we can't build an X-ray microscope to look at molecules, for two
reasons. First, we don't have an X-ray lens. Second, even if we did have one
, it would have to be made with tolerances significantly less than the
distance between two atoms! However, we can (in effect) simulate an X-ray
lens on a computer. You can think of a microscope as working in two stages.
First, light strikes the object and is diffracted in various directions. The
lens collect... 阅读全帖
g****1
发帖数: 261
46
Does anybody have access to this two new reviews? Thanks!
g****[email protected]
Identification of Direct Protein Targets of Small Molecules
Brett Lomenick, Richard W. Olsen, and Jing Huang
Articles ASAP (As Soon As Publishable)
Publication Date (Web): November 16, 2010 (Reviews)
DOI: 10.1021/cb100294v
Using Small Molecules and Chemical Genetics To Interrogate Signaling
Networks
Scott M. Carlson and Forest M. White
Articles ASAP (As Soon As Publishable)
Publication Date (Web): November 16, 2010 (Revie... 阅读全帖
m**z
发帖数: 787
47
Don't know if anybody agrees with me...
I don't see any direct data showing a molecule with covalently As instead of
P, such as mass spec data showing a DNA molecule with As not P. Most of the
arguement in the paper appear to say: if our model is right, xxxx will
happen. We observed xxxx, it is consistent with our model...
L**********O
发帖数: 1761
48
http://www.slate.com/id/2276919
Scientists see fatal flaws in the NASA study of arsenic-based life.
By Carl ZimmerPosted Tuesday, Dec. 7, 2010, at 10:53 AM ET
On Thursday, Dec. 2, Rosie Redfield sat down to read a new paper called, "A
Bacterium That Can Grow by Using Arsenic Instead of Phosphorus." Despite its
innocuous title, the paper had great ambitions. Every living thing that
scientists have ever studied uses phosphorus to build the backbone of its
DNA. In the new paper, NASA-funded scienti... 阅读全帖
g*********d
发帖数: 233
49
交大招的法国Nobel奖原来是去搞伪科学的
http://www.btsmth.com/show_snapshot.php?en_name=TsinghuaCent&gid=456861
Science诺奖得主吕克·蒙塔尼访谈
French Nobelist Escapes "Intellectual Terror" to Pursue Radical Ideas in
China
Martin Enserink
PARIS—Virologist and Nobel laureate Luc Montagnier announced earlier
this month that, at age 78, he will take on the leadership of a new
research institute at Jiaotong University in Shanghai. What has shocked
many scientists, however, isn't Montagnier's departure from France but
what he pla... 阅读全帖
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