x*****g 发帖数: 82 | 1 Position 1 in Nanotechnology for Cancer Molecular Imaging
Description of project: A postdoctoral position is available immediately to
focus on using pH-activatable fluorescent nanoprobes to amplify tumor
contrast with significant background suppression for image-guided resection
of head and neck tumors (HNCA). Prospective candidates will have the
opportunity to work in a highly productive multi-disciplinary environment
with a team of experts in basic and translational research. In particular,
the candidate will have the opportunity to work with Baran D. Sumer, M.D., a
head and neck surgeon who has vast expertise in robotic surgery of HNCA
tumors. The proposed study will use state-of-the-art nanotechnology and
molecular imaging techniques and tumor model systems (e.g. tumor chamber
models) to investigate the imaging efficacy of novel nanoprobes that target
tumor stroma and cancer cells in vivo, and eventually guide surgical
resection of orthotopic HNCA tumors in animals. Funding will be provided by
CPRIT grant support.
Applicants must hold a Ph.D. degree with extensive knowledge and experience
in molecular imaging, cancer biology, tumor physiology, or related fields.
Preferences will be given to candidates with a combination of the following
skills: cell culture, confocal imaging, small animal NIR imaging, common
tissue staining techniques, and animal study.
Position 2 in -Lapachone Nanotherapeutics
Description of project: A postdoctoral position is available immediately to
focus on the study of molecular mechanisms of -lapachone and related
quinone-based drugs for enzyme-bioactivatable therapy of cancer. New drug
candidates and nano delivery systems will be developed to evaluate their
safety and antitumor efficacy in preclinical animal models. Prospective
candidates will have the opportunity to work in a highly productive and
multi-disciplinary environment with a team of experts in basic and
translational research. In particular, the candidate will have the
opportunity to work with a renowned cancer biologist, Dr. David Boothman,
who has great expertise in enzyme-targeted therapy of cancer. The proposed
study will use molecular, cell biology and imaging techniques to investigate
pharmaco-cores that induce unique cell death mechanisms, design novel nano
delivery systems to improve pharmacokinetics, and evaluate antitumor
efficacy in tumor-bearing mice in vivo. Funding will be provided by CPRIT
grant support.
Applicants must hold a Ph.D. degree with extensive knowledge and experience
in medicinal chemistry, pharmacology, cancer biology, or related fields.
Preferences will be given to candidates with biochemistry or pharmaceutics
background and familiar with drug metabolism and medicinal chemistry.
Please email curriculum vitae (CV), as well as names and contact information
of three (3) references to: j*********[email protected] |
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