j*******g
发帖数: 10 | 1 please email to j*****[email protected], thanks a lot!
Growth Factors. 2004 Sep;22(3):151-5.
Thrombopoietin signalling in physiology and disease.
Fishley B, Alexander WS.
Source
The Walter and Eliza Hall Institute for Medical Research, IG Royal Parade,
Parkville, VIC. 3050, Australia.
Abstract
Thrombopoietin (TPO) is a key physiological regulator of steady-state
megakaryocytopoiesis, the process of megakaryocyte production and maturation
that ultimately results in the formation of platelets. Ten years have
passed since the purification and cloning of TPO and extensive studies of
the activities of recombinant forms of the cytokine, as well as analyses of
genetically modified mice lacking or over-expressing TPO or its receptor c-
Mpl, have defined the role of TPO in megakaryocytopoiesis as well as
uncovered unanticipated actions. Biochemical analyses have identified a
number of signalling pathways, including the Jak/signal transducers and
activators of transcription (STAT) and Ras cascades that transmit signals
from the activated cell surface receptor complex to the cell nucleus
resulting in changes in gene expression and the biological responses of TPO-
stimulated cells. Since TPO is the most potent known stimulus of platelet
production in vivo, the evaluation of this cytokine for clinical use in the
treatment of thrombocytopenia is being actively pursued and recent studies
have suggested that aberrations in the TPO signalling pathway may contribute
to disease.
http://www.ncbi.nlm.nih.gov/pubmed/15518238 |
