n***p
发帖数: 79 | 1 http://www.sandiegouniontribune.com/news/2016/aug/31/roger-tsien-dies/
UC San Diego researcher Roger Tsien, who shared the 2008 Nobel Prize in
chemistry for helping find a more effective way to see potentially deadly
cells, died on Aug. 24th. He was 64.
Tsien died in Eugene, Oregon, according to UC San Diego Chancellor Pradeep
Khosla, who broke the news to the campus community on Wednesday.
The university said it appears that Tsien died on a bike trail. The precise
cause of his death has yet to be determined.
Khosla said in a statement, "Roger is best known, of course, as co-winner of
the 2008 Nobel Prize in chemistry for his work with Osamu Shimomura and
Martin Chalfie. Together they collaborated to discover and develop green
fluorescent protein (GFP), derived from the jellyfish Aequorea victoria, as
a new and soon-indispensable research tool.
"Shimomura identified the crucial jellyfish protein and revealed that it
glowed bright green under ultraviolet light. Chalfie showed how it could be
used as a biological marker. Combining his deep skills in chemistry and
biology, Tsien found ways to make GFP glow more brightly and consistently;
then he created a full palette of fluorescent proteins that scientists could
use to track different cellular processes at the same time.
"GFPs have become a fundamental fixture in life sciences labs around the
world, allowing researchers to look into cells or whole animals, to watch
molecules interact in real-time and ask questions once thought impossible."
The news of Tsien's death caused mourning across the Torrey Pines Mesa in La
Jolla, home to one of the nation's largest science clusters.
“Roger Tsien was truly one of the most remarkable and inspiring scientists
of our time,” says Elizabeth Blackburn, a Nobel laureate and president of
the Salk Institute. “He will be sorely missed as a colleague for his
revolutionary work and keen mind, and also as a wonderful person. I felt
privileged to get to know him over the years."
In a statement, Tsien's wife, Wendy, said, “He was ahead of us all. He was
ever the adventurer, the pathfinder, the free and soaring spirit. Courage,
determination, creativity and resourcefulness were hallmarks of his
character. He accomplished much. He will not be forgotten.” | h*****b
发帖数: 492 | 2 RIP
precise
of
【在 n***p 的大作中提到】
: http://www.sandiegouniontribune.com/news/2016/aug/31/roger-tsien-dies/
: UC San Diego researcher Roger Tsien, who shared the 2008 Nobel Prize in
: chemistry for helping find a more effective way to see potentially deadly
: cells, died on Aug. 24th. He was 64.
: Tsien died in Eugene, Oregon, according to UC San Diego Chancellor Pradeep
: Khosla, who broke the news to the campus community on Wednesday.
: The university said it appears that Tsien died on a bike trail. The precise
: cause of his death has yet to be determined.
: Khosla said in a statement, "Roger is best known, of course, as co-winner of
: the 2008 Nobel Prize in chemistry for his work with Osamu Shimomura and
| s********s
发帖数: 3945 | 3 RIP
precise
of
【在 n***p 的大作中提到】
: http://www.sandiegouniontribune.com/news/2016/aug/31/roger-tsien-dies/
: UC San Diego researcher Roger Tsien, who shared the 2008 Nobel Prize in
: chemistry for helping find a more effective way to see potentially deadly
: cells, died on Aug. 24th. He was 64.
: Tsien died in Eugene, Oregon, according to UC San Diego Chancellor Pradeep
: Khosla, who broke the news to the campus community on Wednesday.
: The university said it appears that Tsien died on a bike trail. The precise
: cause of his death has yet to be determined.
: Khosla said in a statement, "Roger is best known, of course, as co-winner of
: the 2008 Nobel Prize in chemistry for his work with Osamu Shimomura and
| I********y
发帖数: 17 | | w********h
发帖数: 12367 | 5 华人诺奖得主，最年轻的钱永健倒第一个去世。。。。
precise
of
【在 n***p 的大作中提到】
: http://www.sandiegouniontribune.com/news/2016/aug/31/roger-tsien-dies/
: UC San Diego researcher Roger Tsien, who shared the 2008 Nobel Prize in
: chemistry for helping find a more effective way to see potentially deadly
: cells, died on Aug. 24th. He was 64.
: Tsien died in Eugene, Oregon, according to UC San Diego Chancellor Pradeep
: Khosla, who broke the news to the campus community on Wednesday.
: The university said it appears that Tsien died on a bike trail. The precise
: cause of his death has yet to be determined.
: Khosla said in a statement, "Roger is best known, of course, as co-winner of
: the 2008 Nobel Prize in chemistry for his work with Osamu Shimomura and
| C*****l
发帖数: 3211 | | m****a
发帖数: 270 | | l********e
发帖数: 415 | 8 最年轻的分明是晓波。
: 华人诺奖得主，最年轻的钱永健倒第一个去世。。。。
: precise
: of
【在 w********h 的大作中提到】
: 华人诺奖得主，最年轻的钱永健倒第一个去世。。。。
:
: precise
: of
| w********h
发帖数: 12367 | 9 科学奖外，你认为此版care？
【在 l********e 的大作中提到】
: 最年轻的分明是晓波。
:
:
: 华人诺奖得主，最年轻的钱永健倒第一个去世。。。。
:
: precise
:
: of
:
| h*****7
发帖数: 227 | | | | l********e
发帖数: 415 | 11 自诩为科学家的话，准确描述事实是基本功。
: 科学奖外，你认为此版care？
【在 w********h 的大作中提到】
: 科学奖外，你认为此版care？
| w********h
发帖数: 12367 | 12 第一，你不懂特殊语境的省略；
第二，你假设别人需要被你补充知识。
【在 l********e 的大作中提到】
: 自诩为科学家的话，准确描述事实是基本功。
:
:
: 科学奖外，你认为此版care？
:
| i******u
发帖数: 937 | 13 钱永健之前得过两次中风。本来情况就不乐观
precise
of
【在 n***p 的大作中提到】
: http://www.sandiegouniontribune.com/news/2016/aug/31/roger-tsien-dies/
: UC San Diego researcher Roger Tsien, who shared the 2008 Nobel Prize in
: chemistry for helping find a more effective way to see potentially deadly
: cells, died on Aug. 24th. He was 64.
: Tsien died in Eugene, Oregon, according to UC San Diego Chancellor Pradeep
: Khosla, who broke the news to the campus community on Wednesday.
: The university said it appears that Tsien died on a bike trail. The precise
: cause of his death has yet to be determined.
: Khosla said in a statement, "Roger is best known, of course, as co-winner of
: the 2008 Nobel Prize in chemistry for his work with Osamu Shimomura and
| m****a
发帖数: 270 | 14 《知识分子》得到的一封邮件透露，钱永健当天独自一人骑着自行车出去的，但是一直
未归，他的妻子温迪·格劳伯·钱（Wendy Globe Tsien）报警，找到他时已经去世。
钱永健以前中风过，恢复后重新工作。钱永健此次单独骑车后没有回家，被找到时已经
去世，很可能是再发中风。不过，更准确的死亡原因还需要确认。 | p******h
发帖数: 163 | | p*******7
发帖数: 134 | 16 学学杨振宁，回中国领个翁帆，肯定多活几年。
人，太不开化 | a****i
发帖数: 4783 | 17 钱是F外，回国显然不适应，因此不可能，
【在 p*******7 的大作中提到】
: 学学杨振宁，回中国领个翁帆，肯定多活几年。
: 人，太不开化
| m*********D
发帖数: 1727 | 18 RIP.
钱先生这一走，我最担心的是那个Prasher的饭碗了：
（Zt from WiKi）
Career[edit]
Prasher received his Ph.D. in Biochemistry from the Ohio State University in
1979. From 1979 to 1983, he worked in genetics and biochemistry research at
the University of Georgia, where he identified the gene sequence for
aequorin [1] .[4] He then joined the Biology Department of the Woods Hole
Oceanographic Institution, Woods Hole, Massachusetts where he studied
bioluminescence. In 1988, he received a two-year, $200,000 grant from the
American Cancer Society to clone the gene for green fluorescent protein (GFP
), the protein that gives the jellyfish its glow. Prasher succeeded in this
project, and later shared his findings with Martin Chalfie and Roger Y.
Tsien after each scientist had communicated with him.[5][6] In subsequent
years, Prasher provided the clone to hundreds of scientists.[citation needed]
Reports that Prasher had difficulty in achieving fluorescence of GFP in
other species in recombinant studies [7] are inaccurate, as Prasher had
successfully worked with the Chalfie group to show recombinant expression in
the bacterium E. coli and the nematode C. elegans,[8] and later in the
plant Arabidopsis thaliana.[9] By the time Prasher's ACS funding ended, he
had isolated a partial, but almost complete gfp cDNA, with 965 bases out of
the 10,50 bases of the corresponding mRNA.[2] It would require construction
of another cDNA library during the following (non-funded) year for Prasher
to isolate a full-length cDNA clone, although it must be noted that this
partial cDNA clone was subsequently used and found to be sufficient for
successful heterologous expression in E. coli, C. elegans [8] and A.
thaliana.[9] By this time Prasher could not afford to devote limited
resources to expression studies in E. coli.[citation needed] It wasn't until
the Nobel Prize announcement that it became clear how unfortunate this had
been. Chalfie and Tsien went on to their successful expression studies. GFP
has subsequently found application as a biochemical tracer such as in
fluorescent studies of gene expression.
Prasher had applied to the National Institutes of Health for funding but had
been turned down, and by the time he was undergoing review for promotion
from assistant to untenured associate, he had decided to leave academia.[
citation needed] Subsequently, Prasher worked for the Animal & Plant Health
Inspection Service,[1] U.S. Department of Agriculture at its Otis Plant
Protection Center in Cape Cod, Massachusetts as a population geneticist, and
was later transferred to the Plant Germplasm Quarantine & Biotechnology
Laboratory in Beltsville, Maryland. After working conditions deteriorated at
the Beltsville location, he went to work for NASA subcontractor AZ
Technology in Huntsville, Alabama working on an existing project to develop
lab-on-a-chip devices to monitor cabin environment and to perform human
diagnostics during long-term spaceflight.[citation needed] However, he lost
his job after 1.5 years when NASA reorganized and canceled the project.[10][
11]
On 8 October 2008, the 2008 Nobel Prize in Chemistry was awarded to Osamu
Shimomura, Chalfie, and Tsien for their work on GFP.[12] Prasher was not
included among the Nobel laureates, as only 3 individuals can share in a
single Nobel Prize. Chalfie said of Prasher's contribution:
"(Douglas Prasher's) work was critical and essential for the work we did in
our lab. They could've easily given the prize to Douglas and the other two
and left me out."[13]
Tsien also agreed that they couldn't have done it without Prasher and "Doug
Prasher had a very important role."[14]
In an October 9, 2008 phone interview with National Public Radio (NPR) and
October 14, 2008 TV interview with Inside Edition, Prasher reported that he
was unable to find a job in science, his life savings had run out and that
he was working as a courtesy shuttle bus driver for a Toyota dealership in
Huntsville, Alabama at $8.50 an hour.[6][11][13][14][15] In the NPR
broadcast, one of his former colleagues called Prasher's current situation a
"staggering waste of talent".[6] Prasher has stated his wish to resume a
career in science, but not particularly with jellyfish.[10] He has publicly
expressed his pleasure at learning of the awarding of the Nobel Prize to
Shimomura, Chalfie and Tsien:
"I'm really happy for them. I was really surprised that particular topic
carried that much weight."[10]
Chalfie and Tsien invited Prasher and his wife, Virginia Eckenrode, to
attend the Nobel Prize ceremony, as their guests and at their expense.[16]
All three of the 2008 Chemistry laureates thanked Prasher in their speeches.
[17]
In June 2010, Prasher was finally able to return to science, working for
Streamline Automation in Huntsville until December 2011, then from 2012 on,
in Roger Tsien's lab at the University of California in San Diego[18] | m*******s
发帖数: 38 | 19 钱永健妻温迪·格劳伯·钱（Wendy Globe Tsien）女士，无子女，有一继子。 | l*****n
发帖数: 1648 | 20 24号就死了，今天才公布，奇怪。
precise
of
【在 n***p 的大作中提到】
: http://www.sandiegouniontribune.com/news/2016/aug/31/roger-tsien-dies/
: UC San Diego researcher Roger Tsien, who shared the 2008 Nobel Prize in
: chemistry for helping find a more effective way to see potentially deadly
: cells, died on Aug. 24th. He was 64.
: Tsien died in Eugene, Oregon, according to UC San Diego Chancellor Pradeep
: Khosla, who broke the news to the campus community on Wednesday.
: The university said it appears that Tsien died on a bike trail. The precise
: cause of his death has yet to be determined.
: Khosla said in a statement, "Roger is best known, of course, as co-winner of
: the 2008 Nobel Prize in chemistry for his work with Osamu Shimomura and
| | | d******2
发帖数: 884 | | x***m
发帖数: 345 | 22 Thanks for the Prasher story, much unlike the graphene story.
in
at
【在 m*********D 的大作中提到】
: RIP.
: 钱先生这一走，我最担心的是那个Prasher的饭碗了：
: （Zt from WiKi）
: Career[edit]
: Prasher received his Ph.D. in Biochemistry from the Ohio State University in
: 1979. From 1979 to 1983, he worked in genetics and biochemistry research at
: the University of Georgia, where he identified the gene sequence for
: aequorin [1] .[4] He then joined the Biology Department of the Woods Hole
: Oceanographic Institution, Woods Hole, Massachusetts where he studied
: bioluminescence. In 1988, he received a two-year, $200,000 grant from the
| c********n
发帖数: 225 | 23 钱永健老师离世了
世界失去了一个 great mind
但是，在世界很多地方
钱先生对于人类的贡献
都化作 不息的生命之光
每天都在 闪耀着
致敬钱老师
http://www.mitbbs.com/pc/pccon_14459_t0_327531.html | c****n
发帖数: 1108 | 24 钱温球。
【在 m*******s 的大作中提到】
: 钱永健妻温迪·格劳伯·钱（Wendy Globe Tsien）女士，无子女，有一继子。
| l*******1
发帖数: 16217 | | s******c
发帖数: 331 | 26 有幸听过一次钱在中风之后给的talk，虽然行动不变，但是头脑异常清晰明白，对自己
做的东西的优势和局限性毫不讳言，对他不太熟悉的领域也非常能一针见血提出问题，
他讲到自己实验室现在做的东西也是非常有逻辑非常清晰明了的，是我觉得印象非常深
刻真正大师级人物的讲演，RIP。
另外，请不要那些打了鸡血的人来没有底线的贬低他。即便现在做科研的一堆追名逐利
之辈，但是也不能贬低这种真正的科学家和他的贡献。 | l******8
发帖数: 1691 | 27 James Watson到底是怎么回事，和钱中风有没有关系？
precise
of
【在 n***p 的大作中提到】
: http://www.sandiegouniontribune.com/news/2016/aug/31/roger-tsien-dies/
: UC San Diego researcher Roger Tsien, who shared the 2008 Nobel Prize in
: chemistry for helping find a more effective way to see potentially deadly
: cells, died on Aug. 24th. He was 64.
: Tsien died in Eugene, Oregon, according to UC San Diego Chancellor Pradeep
: Khosla, who broke the news to the campus community on Wednesday.
: The university said it appears that Tsien died on a bike trail. The precise
: cause of his death has yet to be determined.
: Khosla said in a statement, "Roger is best known, of course, as co-winner of
: the 2008 Nobel Prize in chemistry for his work with Osamu Shimomura and
|
|
