由买买提看人间百态

boards

本页内容为未名空间相应帖子的节选和存档,一周内的贴子最多显示50字,超过一周显示500字 访问原贴
Chemistry版 - 送包子求—on site talk topic(analytical develoment)
相关主题
分析化学phD面试都问什么啊Looking for organic chemist for side projects
请教:用GC测糖的purity-不是identification南加LC/MS/MS工作机会
20伪币求帮做HPLC的信息快来看东莞某药厂的HPLC森林(C&EN记者受不了)
申请分析化学pHD,求建议听说有机不行了
实验室要换HPLC, 有啥推荐的,多谢!现在Fresh phD薪资行情坏到这个地步了
Research Associate position at South San Francisco for BS/M (转载)请问无锡药明康德的principal scientist-protein science干啥的
四川的猴子Zz为什么同样是outsource,化学与IT的差别这么大?
找工作心得(分析化学专业)Open Position: Business Development Agent/Marketing Represe (转载)
相关话题的讨论汇总
话题: talk话题: drug话题: work话题: method话题: site
进入Chemistry版参与讨论
1 (共1页)
e***m
发帖数: 725
1
求过来人经验谈!
最近正在找工作,拿到on-site interview若干,可惜都给人家当分母了。
我们现在的组(药物分析,质检)就我一个外国人,其他全是美国人,而且都是比较喜
欢说,而且技术不行的那一类。平时最喜欢的就是抱怨,打嘴炮,一到动手做试验,要
么失败,要么拖着找理由不做。慢慢的,领导也知道谁行谁不行,结果就形成一个怪圈
,越不会做,反而不用作了。其结果就是难度高的实验都压在我一个人身上。我自己起
早贪黑,别人一句“不会”,就能在边上闲聊,看着我忙,偶尔来一句我最讨厌的how
things are going? FXXK,要不是你连着失败了三次,我用得着这么忙吗?
现在又得到一个on site机会,年景不好,机会难得,打算好好争取。
我需要再interview过程中给一个talk,问题来了。
自从进了industry,我的背景主要来自于graduate (有机加分析),CMO(小分子药物合
成,分析方法),CRO(HPLC method development, substances and pre-formulation)
, CMO(QC, method transfer, stability coordinator).工作做得比较多,但是比较
散,而且所有的东西都是confidential,没有办法组织成一个完整地talk.我所面试的
组也要求要分析,有机背景,method development, routine QC testing,
documentation review。算是比较合适的。
真怀念以前graduate的时候,自己的作的东西,很完整,很有趣,想怎么讲就怎么讲。
现在做了这么多,竟然不知道还能讲什么。觉得自己懂的东西挺多,所学驳杂,但不精
—— CRO/CMO通病。我估计我的论文人家也不感兴趣。
上一个on site就是因为talk太过general结果fail,不知道大家有没有什么好的建议。
如果国谁讲过类似的talk能不能让我分享借鉴一下?多谢多谢。
b*******g
发帖数: 1309
2
牛人,给俺推荐个工作吧。。。。
talk 还是讲一到两个相关project为宜,不要太多。

how

【在 e***m 的大作中提到】
: 求过来人经验谈!
: 最近正在找工作,拿到on-site interview若干,可惜都给人家当分母了。
: 我们现在的组(药物分析,质检)就我一个外国人,其他全是美国人,而且都是比较喜
: 欢说,而且技术不行的那一类。平时最喜欢的就是抱怨,打嘴炮,一到动手做试验,要
: 么失败,要么拖着找理由不做。慢慢的,领导也知道谁行谁不行,结果就形成一个怪圈
: ,越不会做,反而不用作了。其结果就是难度高的实验都压在我一个人身上。我自己起
: 早贪黑,别人一句“不会”,就能在边上闲聊,看着我忙,偶尔来一句我最讨厌的how
: things are going? FXXK,要不是你连着失败了三次,我用得着这么忙吗?
: 现在又得到一个on site机会,年景不好,机会难得,打算好好争取。
: 我需要再interview过程中给一个talk,问题来了。

S*****n
发帖数: 6055
3
就用graduate的工作来讲就行吧。。。
工作经历里面的具体内容是confidential,但是skill sets总是可以讲的吧。。。这些
放在one on one的时候跟人家说明白就好了

how

【在 e***m 的大作中提到】
: 求过来人经验谈!
: 最近正在找工作,拿到on-site interview若干,可惜都给人家当分母了。
: 我们现在的组(药物分析,质检)就我一个外国人,其他全是美国人,而且都是比较喜
: 欢说,而且技术不行的那一类。平时最喜欢的就是抱怨,打嘴炮,一到动手做试验,要
: 么失败,要么拖着找理由不做。慢慢的,领导也知道谁行谁不行,结果就形成一个怪圈
: ,越不会做,反而不用作了。其结果就是难度高的实验都压在我一个人身上。我自己起
: 早贪黑,别人一句“不会”,就能在边上闲聊,看着我忙,偶尔来一句我最讨厌的how
: things are going? FXXK,要不是你连着失败了三次,我用得着这么忙吗?
: 现在又得到一个on site机会,年景不好,机会难得,打算好好争取。
: 我需要再interview过程中给一个talk,问题来了。

w*********l
发帖数: 5144
4
给你建议一个 讲讲mass balance啥的, 会触着他们的痒处

how

【在 e***m 的大作中提到】
: 求过来人经验谈!
: 最近正在找工作,拿到on-site interview若干,可惜都给人家当分母了。
: 我们现在的组(药物分析,质检)就我一个外国人,其他全是美国人,而且都是比较喜
: 欢说,而且技术不行的那一类。平时最喜欢的就是抱怨,打嘴炮,一到动手做试验,要
: 么失败,要么拖着找理由不做。慢慢的,领导也知道谁行谁不行,结果就形成一个怪圈
: ,越不会做,反而不用作了。其结果就是难度高的实验都压在我一个人身上。我自己起
: 早贪黑,别人一句“不会”,就能在边上闲聊,看着我忙,偶尔来一句我最讨厌的how
: things are going? FXXK,要不是你连着失败了三次,我用得着这么忙吗?
: 现在又得到一个on site机会,年景不好,机会难得,打算好好争取。
: 我需要再interview过程中给一个talk,问题来了。

e***m
发帖数: 725
5
May I ask what mass balance means?
Thanks.

【在 w*********l 的大作中提到】
: 给你建议一个 讲讲mass balance啥的, 会触着他们的痒处
:
: how

w*********l
发帖数: 5144
6
ft.... means ur analytical method can recover all the drug on ur product,
part of impurity analysis. if mass balance defeciency is with 2%, FDA will
not ask u any question, 2 to 3%, maybe, up to who review ur package. over 3%
, get prepared to answer FDA questions regarding ur impuirty method.

【在 e***m 的大作中提到】
: May I ask what mass balance means?
: Thanks.

e***m
发帖数: 725
7
看来哥们内行,我所做得mass balance 都是percent area normality,好像不怎么深
入,你觉得这个有啥可以挖掘的吗?

will
3%

【在 w*********l 的大作中提到】
: ft.... means ur analytical method can recover all the drug on ur product,
: part of impurity analysis. if mass balance defeciency is with 2%, FDA will
: not ask u any question, 2 to 3%, maybe, up to who review ur package. over 3%
: , get prepared to answer FDA questions regarding ur impuirty method.

w*********l
发帖数: 5144
8
当然可以, 讲impurity generation, 讲response factor of different methodology
等, 能展很开

【在 e***m 的大作中提到】
: 看来哥们内行,我所做得mass balance 都是percent area normality,好像不怎么深
: 入,你觉得这个有啥可以挖掘的吗?
:
: will
: 3%

e***m
发帖数: 725
9
先送个包子,有没有杀可以参考的资料,我觉得job-related presentation就是展开一
个讨论,人们可以initiate一个talk至于哪里来的资料,好像并不关键
p*******8
发帖数: 158
10
Can give a talk as to how we do an ANDA through A to Z. Just use some kind
of generic drug as an example. Literature search work, similar product on
market, price, profits and market prospect; then drug substance (API)
analysis (source and purity); formulation work (excipient source and
selection); drug product master files (HPLC methodology development and
validation, physical and chemical constants, other instrumentation and wet
chemistry, dissolution, stability test, relative substances); pharmacology
and toxicology (animal test); manufacture report and QC; waiver of clinical
trial; specification and use of this drug (strength, purity, package et al)
;
For some kind of drug in which API can not be obtained in China, this
process is more complex. Drug substance synthesis have to be monitored and
assayed from starting materials, intermediates, impurities, by products and
final API product. The drug files could be double. Then going though all
other procedures like generic drug.
You know, in China, they seldom develop a totally new drug. But all those
experiences from here are enough for an analytical chemist to work in US.
They also conduct work in compliance with cGMPs (mainly for APIs), GLP,
safety and regulatory requirements.
Although I just participate in some of work , like formulation, animal test,
organic synthesis and manufacture, I was required to organize and conduct
every section, and responsible for final drug profile submission to SFDA and
provide sample and reference and method transfer into their instrument.
After approval, I still need to do quality assay and troubleshoot for
production. Whatever, they all can be talked as part of your work. Of
course, you should work very hard so you can meet timeline set by leader.
So our colleagues and I worked from 7:30 am to 11:30 pm almost every day (
just an additional convenient dinner is offered), and also frequently worked
on weekends and holidays. A large amount of experiments and files have to
be finished. And multiple projects have to be performed at the same time.
You can read some materials from FDA or SFDA, finding a general case
similar to your already finished one (so there is no worry about secret
leaking), and then describing how you did or will do analysis on this case.
I feel you may search some ppt at google about drug analysis, and hope
to incorporate your knowledge into them. For pharm analysis, there is only
one interesting thing---method development. That's only thing you may
develop your own idea on your work. Other works are routine and chore.
But you don't want to show you are hating that while hunting job. You
should force you love it, then the people you hope to service will love you.
Americans are always overconfident on talking their work or others' work
even if they did that not so well. Actually we should learn it from that,
and talk about our work with enough water and enthusiasm.
Btw, you should talk to your boss at first beginning, to show what you
finished, how diligent you are (do not talk others lazy) and you deserve
double pay. If you did not fight back, they just pretended they didn't
know this thing (looks like this is some kind of American courtesy). Of
course, now it's better time to move on.
1 (共1页)
进入Chemistry版参与讨论
相关主题
Open Position: Business Development Agent/Marketing Represe (转载)实验室要换HPLC, 有啥推荐的,多谢!
请教有经验的各位牛人,可否评价一下Research Associate position at South San Francisco for BS/M (转载)
分析主管 地点:国内四川的猴子Zz
分析主管 地点:国内找工作心得(分析化学专业)
分析化学phD面试都问什么啊Looking for organic chemist for side projects
请教:用GC测糖的purity-不是identification南加LC/MS/MS工作机会
20伪币求帮做HPLC的信息快来看东莞某药厂的HPLC森林(C&EN记者受不了)
申请分析化学pHD,求建议听说有机不行了
相关话题的讨论汇总
话题: talk话题: drug话题: work话题: method话题: site