W******r
发帖数: 789 | 1 60年代末美国华盛顿特区的儿童接种了RSV疫苗，结果80%接种疫苗的儿童生病住院，其
中2人死亡。差不多40年之后人们才解开这个谜。原来儿童的抗体并没有像预料中那样
足够紧密地和疫苗里面处理过的病毒结合。抗体只是拖着病毒到处走，从而触发了其他
大规模的免疫反应。
这是一个很好的例子，它说明了现代医学对人体只有非常肤浅的认识。疫苗和人工合成
的化学药品进入人体之后对人体引起的生理变化和反应永远不会刚好就是人们所设计的
那样，任何一个微小细节的偏差都有可能引起不可预知的灾难性的错误。一旦发生错误
也远非现代医学的能力所能处理，很多时候就是无可挽回的了。
人体有其自身的规律，现代医学对此所知甚少。一旦这个规律被扰乱，例如用疫苗，西
药，人工合成的营养素，或者大规模地用化学方法处理和精炼食品，把食品工业化，转
基因，人体就会对此作出反应，从而引起人体的改变，可能还是不可逆的。但是人体会
有什么反应和改变却没有人能彻底研究清楚，有些看得到，有些看不到。我们知道的只
是冰山一角。不知道有什么风险才是最大的风险。
到了细胞和分子这样的微观层次，人体结构的复杂程度已经远远超过了现代医学所能把
握和处理的程度。在一个自己不能把握的微观层次对人体作修改是必然会产生错误的。
现代医学的发展过程其实就是用比较隐蔽的错误去掩饰比较明显的错误，等到这个隐蔽
的错误变得明显，又用另外一个隐蔽的错误去掩饰它。
在这方面我们要向我们的祖先学习。要顺应自然规律，天人合一。要敬畏自然，不要用
威力巨大的方式去干扰它。这样方能让生命焕发出生命本来应有的色彩。
资料来源
http://articles.mercola.com/sites/articles/archive/2009/01/13/d | s********e
发帖数: 427 | 2 我找到了John Hopkins那里的链接。
Hopkins-Led Team Solves Failed Vaccine Mystery
MEDIA CONTACT: Ekaterina Pesheva
EMAIL: e******[email protected]
PHONE: (410) 502-9433
December 15, 2008
Research led by Johns Hopkins Children's Center scientists has figured out
why a respiratory syncytial virus vaccine used in 1966 to inoculate children
against the infection instead caused severe respiratory disease and
effectively stopped efforts to make a better one.
The findings, published online on Dec. 14 in Nature Medicine, could restart
work on effective killed-virus vaccines not only for RSV but other
respiratory viruses, researchers say. The new findings also debunk a popular
theory that the 1966 vaccine was ineffective because the formalin used to
inactivate the virus disrupted critical antigens, the substances that
stimulate the production of protective antibodies.
Instead, researchers said, the problem occurred when the antibodies created
by the vaccine failed to successfully bind to the real virus after exposure
to it, thereby incapacitating it. Like vaccines against influenza and polio,
the 1966 formalin-inactivated RSV vaccine produced antibodies, but these
turned out to be defective ones with poor virus-binding ability.
"We have found the root cause of the problem, and in doing so we have
uncovered clues that will help us design even safer and more effective
vaccines in the future," says senior investigator Fernando Polack, M.D., an
infectious disease specialist at the Johns Hopkins Children's Center.
More specifically, in a series of experiments, the research team discovered
that the old RSV vaccine failed to trigger a "signaling" mechanism -- called
toll-like receptor activation -- that helps the immune system recognize a
virus and mount a defense against it.
Toll-like receptor activation is the first in cascade of immune system
responses that occur after infection, firing off signals to other immune
cells telling them to produce and release antibodies.
First, the team compared immune system response in three groups of mice:
those vaccinated with a placebo, those with a weakened form of the RSV virus
, and those with inactivated or killed-virus vaccines. Researchers found
that in the last group, the toll-like receptor activation was weak and led
to the production of defective antibodies.
Next, they infused the vaccine with a substance that stimulates toll-like
receptor activation to see if it would created antibodies better equipped to
bind to and neutralize the virus. Indeed, mice vaccinated with the toll-
like receptor stimulating form of the inactivated vaccine produced
antibodies with better binding and virus-neutralizing ability. Mice
immunized with this form of the vaccine had milder symptoms and less
inflammation in the bronchi and the lungs when infected with the real RSV.
RSV is the most common culprit of serious viral infections in newborns and
infants younger than1 year, and the leading cause of hospitalization in this
age group. Half of all infants contract RSV during their first year of life
, and hospitalizations for children with RSV have more than doubled in
recent decades, researchers say.
To date, there is no vaccine against RSV.
Other investigators in the study: Guillermina Melendi and Johanna Zea
Hernandez of Johns Hopkins; Herng-Yu Chang and Wayne Mitzner of the Johns
Hopkins Bloomberg School of Public Health; Maria Florencia Delgado, Silvina
Coviello, A. Clara Monsalvo, Juan Batalle, Leandro Diaz of the INFANT
Foundation, Buenos Aires, Argentina; Alfonsina Trento and Jose Melero, of
Instituto de Salud Carlos III, Madrid, Spain; Jeffrey Ravetch, of
Rockefeller University, New York; Pablo Irusta of Georgetown University
School of Medicine. The research was funded by an NIH grant and money from
the Thomas and Carol McCann Innovative Research Fund for Asthma and
Respiratory Diseases.
Founded in 1912 as the children's hospital of the Johns Hopkins Medical
Institutions, the Johns Hopkins Children's Center offers one of the most
comprehensive pediatric medical programs in the country, with nearly 95,000
patient visits and some 9,000 admissions each year. Hopkins Children’s is
consistently ranked among the top children's hospitals in the nation.
Hopkins Children’s is Maryland's largest children’s hospital and the only
state-designated Trauma Service and Burn Unit for pediatric patients. It has
recognized Centers of Excellence in dozens of pediatric subspecialties,
including allergy, cardiology, cystic fibrosis, gastroenterology, nephrology
, neurology, neurosurgery, oncology, pulmonary, and transplant. For more
information, visit www.hopkinschildrens.org. | s********e
发帖数: 427 | | s********e
发帖数: 427 | 4 我自己算是个学者。当我去用学术的方法分析我所获得的资讯时，很悲哀地，我发现很
多资讯都靠不住。不仅是一般的商业广告，也包括很多学术文章。
当我们对生命的奥秘了解还很有限，我们根本还不能创造出一个细胞的时候（克隆是一
种重组，而不是创造），我们需要敬畏生命。
现代医学，药物制造，和生物工程，有一种极大的傲慢和夸张的信心。
可是生物体复杂的特性，不是我们在短短的药品开发期内能够透彻了解的。
你是否知道Viagra伟哥原本是为治心绞痛而研发的？在临床实验中被发现它有改善阳痿
的情况？对于这种“歪打正着”，你是觉得很有趣，还是觉得很可怕？
如果它的副作用不是改善ED, 而是...... | s********e
发帖数: 427 | | W******r
发帖数: 789 | 6 我以前也是做生物研究的，也是越研究就越发现这些研究都是建立在一些非常粗略的模
型和极不可靠的假设之上。但是现在生物技术非常powerful，假设和现实之间的任何一
个微小差异都有可能造成巨大的灾难，就好像RSV疫苗一样。
【在 s********e 的大作中提到】
: 我自己算是个学者。当我去用学术的方法分析我所获得的资讯时，很悲哀地，我发现很
: 多资讯都靠不住。不仅是一般的商业广告，也包括很多学术文章。
: 当我们对生命的奥秘了解还很有限，我们根本还不能创造出一个细胞的时候（克隆是一
: 种重组，而不是创造），我们需要敬畏生命。
: 现代医学，药物制造，和生物工程，有一种极大的傲慢和夸张的信心。
: 可是生物体复杂的特性，不是我们在短短的药品开发期内能够透彻了解的。
: 你是否知道Viagra伟哥原本是为治心绞痛而研发的？在临床实验中被发现它有改善阳痿
: 的情况？对于这种“歪打正着”，你是觉得很有趣，还是觉得很可怕？
: 如果它的副作用不是改善ED, 而是......
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