Immigration版 - Review opportunity, 制药, European Journal of Pharmaceutic |
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c*********o
发帖数: 1734 | 1 I will recommend the first three responds with the right background to the
editor.
There is no guarantee you will be picked by the editor.
Send email to c*********[email protected] with the following information:
You official name
Your degree
Your business email address
You business title
And brief introduction of your background.
Most important: register with EJPS as a reviewer with your business email
address before you send me email
I will not recommend you if you miss any of above.
"Solid self - emulsifying phospholipid suspension (SSEPS) with diatom as a
drug carrier"
ABSTRACT:
We report the application of diatom as a solid carrier for water insoluble
drugs applied in oral drug delivery system based on the self - emulsifying
drug delivery system (SEDDS) caprylocaproyl macrogol-8 glycerides/ lecithin/
propylene glycol/ caprylic/capric triglyceride. Diatoms are fossilized
skeletons of photosynthetic algae with complex 3 - dimensional (3D), porous
structure consisting of amorphous silica, obtained by purification of
diatomaceous earth. Different solid samples of carbamazepine (CBZ)
suspension in SEDDS, called solid self - emulsifying phospholipid suspension
(SSEPS), were prepared using two methods: adsorption of CBZ dispersion in
SEDDS by gentle mixing with diatoms in mortar with pestle (Method A) or
dispersion of diatoms in ethanol solution of CBZ and SEDDS components,
followed by ethanol evaporation (Method B). Release rate of CBZ from SSEPS
was significantly higher in comparison to pure drug, physical mixture of
diatoms and CBZ as well as solid
dispersion of pure CBZ and diatoms obtained by ethanol evaporation. The
dissolution of CBZ from SSEPS sample prepared using method B was faster than
from the sample prepared by the method A. Higher dissolution for sample
prepared by the method B can be attributed to the partial adsorption (deeper
localization) of liquid material inside the pores of diatoms. Upon storage
of the samples under accelerated conditions (40°C and 70% RH) for 10 weeks
no significant changes in CBZ crystallinity and dissolution was in case of
SSEPS, contrary to solid dispersion with increased crystallinity, indicating
that diatoms with adsorbed liquid CBZ - loaded SEPS can maintain initial
CBZ characteristics. | d******6
发帖数: 276 | 2 sent email and many thanks | x****3
发帖数: 59 | 3 Thank you very much for the opportunity! Just send you an email. Thank you! | H********s
发帖数: 20 | 4 Thank you for the opportuniy.
【在 c*********o 的大作中提到】
: I will recommend the first three responds with the right background to the
: editor.
: There is no guarantee you will be picked by the editor.
: Send email to c*********[email protected] with the following information:
: You official name
: Your degree
: Your business email address
: You business title
: And brief introduction of your background.
: Most important: register with EJPS as a reviewer with your business email
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