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发帖数: 18160 | 1 【 以下文字转载自 Biology 讨论区 】
发信人: Suave911 (911), 信区: Biology
标 题: Post-doc Position Available in Cancer/Signal Transduction
发信站: BBS 未名空间站 (Fri Jun 21 10:21:47 2013, 美东)
Post-doc Position Available in Cancer/Signal Transduction
Molecular Cell Biology, Leiden University Medical Center, The Netherlands
A Post-Doctoral position is available in a dynamic, international and
interdisciplinary research team to study the molecular basis of subverted
TGF-β signal transduction in cancer.
Focus of the research group:
Our group is interested in unraveling mechanisms by which TGF-β family
members elicit their multifunctional cellular effects and how perturbation
in their signal transduction pathways contribute to the metastasis of cancer
cells, vascular disorders and bone diseases. The present focus within our
group is on 1) the identification of novel critical regulators of TGF-β
family signaling pathways, 2) how TGF-β receptor signaling specificity is (
dynamically) regulated and 3) interplay with Wnt and other signaling
pathways. We use mouse and zebrafish models. Our long term aim is to
translate our findings towards the development of novel treatments.
Project description
To identify and characterize the mechanism of action of novel regulators in
TGF- signaling, in particular focus on (de)ubiquitin ligases and
other druggable targets, (2) show the significance of their misregulation in
cancer progression and (3) translate these findings into new drugs/
therapies for (personalized) cancer treatment.
Requirements:
We are searching for a highly motivated and experimentally talented
scientists with drive to answer important research questions. Applicants
should hold a recent Ph.D. and have a strong background in biochemistry and
molecular cell biology and have previous experience in signal transduction.
Reporting and publishing the results in high impact scientific journals and
at international conferences is expected. The employment will be for a
period of 2 years with possibility for extension. Start date: August, 2013
to January 2014.
Selected References:
Zhang et al. (2012) RNF12 controls embryonic stem cell fate and
morphogenesis in zebrafish embryos by targeting Smad7 for degradation. Mol
Cell, 46:650-61.
Zhang et al. (2012) USP4 is regulated by Akt phosphorylation and
deubiquitinates TGF-β type I receptor. Nat Cell Biology, 14:717-26.
Please send a cover letter with curriculum vitae, a description of research
accomplishments, and contact information of two references to:
Peter ten Dijke, Molecular Cell Biology, Leiden University Medical Center,
Postbus 9600, 2300 RC Leiden, The Netherlands; Email: p*********[email protected].
http://www.lumc.nl/con/1050/85468/812090135182537/8121001255725 |
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