q********m
发帖数: 3234 | 1 primary throbocythemia， 骨髓检查发现巨型细胞增多。目前在中国用pegasys控制（
一种alfa干扰素，10天一支，血小板能控制在40万以内）。据说病程缓慢，中位存活期
是10-15年。目前爸爸62岁，如果能再高质量的活20年也够本了。
美国有病因的研究和根治方法的研究吗？爸爸常年吃药，控制心脏病，高血压和胃溃疡
。我和妈妈都认为是乱七八糟药吃多了导致的。
多谢回复，有技术含量的包子答谢 | g*****j
发帖数: 1211 | 2 Primary thrombocythemia (also known as essential thrombocytosis) is caused
by defect in megakaryocyte in bone marrow. Patients with this disease on
average has normal life expectancy. Although the platelet count is high,
the overall blood coagulation function may be low, because the platelets
produced in bone marrow can be defective. The major issue is the management
between thrombosis and hemorrhage.
I believe in US, the recommendation is only treat when patient is
symptomatic. The overall | g***r
发帖数: 285 | 3
management
Complications
very good answer, just few more things to add
1. you have to make sure the diagnosis is essential thrombocythemia, not
polycythemia vera, myelodysplastic syndrome, CML, or any others that have
high risk of converting to leukemia,
2. the patient is 62 yrs old, which would put him into high risk for
thrombotic events(whether to treat is based on thombotic risk rather than on
hemorrhagic risk), so he will need treatment,
3. interferon will reduce platelet counts, but is VE
【在 g*****j 的大作中提到】
: Primary thrombocythemia (also known as essential thrombocytosis) is caused
: by defect in megakaryocyte in bone marrow. Patients with this disease on
: average has normal life expectancy. Although the platelet count is high,
: the overall blood coagulation function may be low, because the platelets
: produced in bone marrow can be defective. The major issue is the management
: between thrombosis and hemorrhage.
: I believe in US, the recommendation is only treat when patient is
: symptomatic. The overall
| q********m
发帖数: 3234 | | q********m
发帖数: 3234 | 5 1. you have to make sure the diagnosis is essential thrombocythemia, not
polycythemia vera, myelodysplastic syndrome, CML, or any others that have
high risk of converting to leukemia,
这个要问一下，在国内做过骨髓穿刺，专家会诊，应该是算确诊的。
2. the patient is 62 yrs old, which would put him into high risk for
thrombotic events(whether to treat is based on thombotic risk rather than on
hemorrhagic risk), so he will need treatment,
考虑血栓了，好像也考虑动脉硬化，您能具体说说吗？
3. interferon will reduce platelet counts, but is VERY expensive and | q********m
发帖数: 3234 | 6 ???????I didn't get it.
Another | q********m
发帖数: 3234 | 7 but my dad's problem is Essential thrombocythemia, not polycythemia vera. | q********m
发帖数: 3234 | |
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