k*******2
发帖数: 1429 | 1 BT proteins are toxic to human cells
Cytotoxicity on human cells of Cry1Ab and Cry1Ac Bt insecticidal toxins
alone or with a glyphosate-based herbicide
Mesnage R., Clair E., Gress S., Then C., Székács A., Séralini G.-E
Article first published online: 15 FEB 2012, Journal of Applied Toxicology
DOI: 10.1002/jat.2712
ABSTRACT
The study of combined effects of pesticides represents a challenge for
toxicology. In the case of the new growing generation of genetically
modified (GM) plants with stacked traits, glyphosate-based herbicides (like
Roundup) residues are present in the Roundup-tolerant edible plants (
especially corns) and mixed with modified Bt insecticidal toxins that are
produced by the GM plants themselves. The potential side effects of these
combined pesticides on human cells are investigated in this work. Here we
have tested for the very first time Cry1Ab and Cry1Ac Bt toxins (10
ppb to 100 ppm) on the human embryonic kidney cell line 293, as well
as their combined actions with Roundup, within 24 h, on three
biomarkers of cell death: measurements of mitochondrial succinate
dehydrogenase, adenylate kinase release by membrane alterations and caspase
3/7 inductions. Cry1Ab caused cell death from 100 ppm. For Cry1Ac,
under such conditions, no effects were detected. The Roundup tested alone
from 1 to 20 000 ppm is necrotic and apoptotic from 50 ppm, far
below agricultural dilutions (50% lethal concentration 57.5 ppm). The
only measured significant combined effect was that Cry1Ab and Cry1Ac reduced
caspases 3/7 activations induced by Roundup; this could delay the
activation of apoptosis. There was the same tendency for the other markers.
In these results, we argue that modified Bt toxins are not inert on
nontarget human cells, and that they can present combined side-effects with
other residues of pesticides specific to GM plants. Copyright © 2012
John Wiley & Sons, Ltd. | y***u
发帖数: 7039 | 2 乌有之乡转载的文章， 对与唤醒各界民众和国家领导，延缓买办认钱不认人的自私毁
国行为，功不可没。 | G**L
发帖数: 22804 | 3 首先声明我对转基因持怀疑态度，主张不是不得已不要吃。
但是，既然是蛋白质，吃到肚里不会被分解吗？
like
【在 k*******2 的大作中提到】
: BT proteins are toxic to human cells
: Cytotoxicity on human cells of Cry1Ab and Cry1Ac Bt insecticidal toxins
: alone or with a glyphosate-based herbicide
: Mesnage R., Clair E., Gress S., Then C., Székács A., Séralini G.-E
: Article first published online: 15 FEB 2012, Journal of Applied Toxicology
: DOI: 10.1002/jat.2712
: ABSTRACT
: The study of combined effects of pesticides represents a challenge for
: toxicology. In the case of the new growing generation of genetically
: modified (GM) plants with stacked traits, glyphosate-based herbicides (like
| k*******2
发帖数: 1429 | 4 "....., we argue that modified Bt toxins are not inert on nontarget human
cells, "
【在 G**L 的大作中提到】
: 首先声明我对转基因持怀疑态度，主张不是不得已不要吃。
: 但是，既然是蛋白质，吃到肚里不会被分解吗？
:
: like
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