l****p
发帖数: 27354 | 1 我想仔细研读到底文章是不是scientifically sound,那些没有被国际主要机构用于
Risk assessment的争论性文章的缺点，是不是真的从实验设计到数据分析都比被这些
机构引用于Risk assessment的文章差？
只模糊记得一片阳性的文章，被一些政府机构批判，但作者反驳说，没有研究是完美的
，我能从那些被用于决策的那些文章中找到更大更多问题。 | y***u
发帖数: 7039 | 2 Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically
modified maize
Food and Chemical Toxicology
Volume 50, Issue 11, November 2012, Pages 4221–4231
Abstract
The health effects of a Roundup-tolerant genetically modified maize (from 11
% in the diet), cultivated with or without Roundup, and Roundup alone (from
0.1 ppb in water), were studied 2 years in rats. In females, all treated
groups died 2–3 times more than controls, and more rapidly. This difference
was vis- ible in 3 male groups fed GMOs. All results were hormone and sex
dependent, and the pathological pro- files were comparable. Females
developed large mammary tumors almost always more often than and before
controls, the pituitary was the second most disabled organ; the sex hormonal
balance was mod- ified by GMO and Roundup treatments. In treated males,
liver congestions and necrosis were 2.5–5.5 times higher. This pathology
was confirmed by optic and transmission electron microscopy. Marked and
severe kidney nephropathies were also generally 1.3–2.3 greater. Males
presented 4 times more large palpable tumors than controls which occurred up
to 600 days earlier. Biochemistry data confirmed very significant kidney
chronic deficiencies; for all treatments and both sexes, 76% of the altered
parameters were kidney related. These results can be explained by the non
linear endocrine-disrupting effects of Roundup, but also by the
overexpression of the transgene in the GMO and its metabolic consequences.
other paper you may want to read:
Zhang, L., Hou, D., Chen, X., Li, D., Zhu, L., Zhang, Y., Li, J., Bian, Z.,
Liang, X., Cai, X., Yin, Y., Wang, C., Zhang, T., Zhu, D., Zhang, D., Xu, J.
, Chen, Q., Ba, Y., Liu, J., Wang, Q., Chen, J., Wang, J., Wang, M., Zhang,
Q., Zhang, J., Zen, K., Zhang, C.Y., 2012. Exogenous plant MIR168a
specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation
by microRNA. Cell Res. 22, 107–126. | l****p
发帖数: 27354 | 3 谢谢！
genetically
11
from
difference
【在 y***u 的大作中提到】
: Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically
: modified maize
: Food and Chemical Toxicology
: Volume 50, Issue 11, November 2012, Pages 4221–4231
: Abstract
: The health effects of a Roundup-tolerant genetically modified maize (from 11
: % in the diet), cultivated with or without Roundup, and Roundup alone (from
: 0.1 ppb in water), were studied 2 years in rats. In females, all treated
: groups died 2–3 times more than controls, and more rapidly. This difference
: was vis- ible in 3 male groups fed GMOs. All results were hormone and sex
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