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发帖数: 768 | 1 这个领域的最新进展，一篇很好的REVIEW，刚刚发表出来的
作者D.Debanne最近发表了不少这个方向的REVIEW文章
http://physrev.physiology.org/content/91/2/555.full
Axon Physiology
Dominique Debanne, Emilie Campanac, Andrzej Bialowas, Edmond Carlier,
and Gisèle Alcaraz
Institut National de la Santé et de la Recherche Médicale U.641 and
Université de la Méditerranée, Faculté de Médecine Secteur Nord,
Marseille, France
Next SectionAbstract
Axons are generally considered as reliable transmission cables in
which stable propagation occurs once an action potential is generated.
Axon dysfunction occupies a central position in many inherited and
acquired neurological disorders that affect both peripheral and
central neurons. Recent findings suggest that the functional and
computational repertoire of the axon is much richer than traditionally
thought. Beyond classical axonal propagation, intrinsic voltage-gated
ionic currents together with the geometrical properties of the axon
determine several complex operations that not only control signal
processing in brain circuits but also neuronal timing and synaptic
efficacy. Recent evidence for the implication of these forms of axonal
computation in the short-term dynamics of neuronal communication is
discussed. Finally, we review how neuronal activity regulates both
axon morphology and axonal function on a long-term time scale during
development and adulthood. |
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