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发帖数: 3360 | 2 不可能一拍脑袋就是5分钟是吧。这个5分钟correlate成sleep大部分时候是没有问题的
。有问题的时候比如果蝇sick了，不动了。用video taping来分析是更好的办法。有果
蝇的EEG分析就最好了，但是需要工程学的人来搞才行。
虽然不完美，但是果蝇的遗传工具实在是太powerful了，不用可惜。个人觉得要希望
sleep homeostasis的分子机制有大的根本的突破，果蝇应该打前锋。有钱人当然也可
以用老鼠来做。去看看American Sleep Association的年会就知道sleep的基础研究实
在太烂了。这么重要的问题这么长时间了没有什么根本的突破。需要在模式生物上有根
本的改变才行。
给你quote一段，有空有兴趣可以看看后面的reference：
“Videotape analyses of Canton-S flies in the monitoring system showed
that 97% of rest bouts last 5 min or more, with the majority of these bouts
lasting 30 min or more (Hendricks et al., 2000). When the beam remains
unbroken for more than 5 min, the fly exhibits a relaxed posture and
quiescent behavior associated with sleep. In contrast, immobile periods less
than a minute long were infrequent and often found interspersed with high
activity, and thus may signify brief rest rather than sleep (Hendricks et al
., 2000). Using an ultrasound system to detect fine movements of the fly,
Shaw et al. (2000) independently corroborated these observations.
Furthermore, a fly at rest for 5 min or longer exhibits increased arousal
thresholds (Huber et al., 2004).”
1. Hendricks, J. C., Finn, S. M., Panckeri, K. A., Chavkin, J., Williams, J.
A., Sehgal, A., and Pack, A. I. (2000). Rest in Drosophila is a sleep-like
state. Neuron 25, 129–138.
2. Shaw, P. J., Cirelli, C., Greenspan, R. J., and Tononi, G. (2000).
Correlates of sleep and waking in Drosophila melanogaster. Science 287, 1834
–1837.
3. Huber, R., Hill, S. L., Holladay, C., Biesiadecki, M., Tononi, G., and
Cirelli, C. (2004). Sleep homeostasis in Drosophila melanogaster. Sleep 27,
628–639.
【在 z*******a 的大作中提到】
: fly people把fly静止5min不动算做睡眠
: 听起来象忽悠
: 大家怎么看？
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