c*******g 发帖数: 695 | 1 天天develop模型?
是不是根程序员差不多了
还是需要bench work的?
industry的朋友讲一下 |
w*****n 发帖数: 980 | |
s**********r 发帖数: 330 | 3 They don't do bench work...Everyday sitting at their desks in front of a
computer, sometimes in meetings, sometimes in training classes. To me their
job is quite boring but maybe they are enjoying themselves.
【在 c*******g 的大作中提到】 : 天天develop模型? : 是不是根程序员差不多了 : 还是需要bench work的? : industry的朋友讲一下
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w*****n 发帖数: 980 | 4 hehe, 很好奇跳舞牛同学是做什么的
their
【在 s**********r 的大作中提到】 : They don't do bench work...Everyday sitting at their desks in front of a : computer, sometimes in meetings, sometimes in training classes. To me their : job is quite boring but maybe they are enjoying themselves.
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c*******g 发帖数: 695 | 5 那就是pharm industry 里面的it民工?
怎么感觉it民工抱怨的多
pk pd抱怨的人少呢?
难道因为样本太少了?
their
【在 s**********r 的大作中提到】 : They don't do bench work...Everyday sitting at their desks in front of a : computer, sometimes in meetings, sometimes in training classes. To me their : job is quite boring but maybe they are enjoying themselves.
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s**********r 发帖数: 330 | 6 It really doesn't matter what I am doing everyday. I do work closely with
both pre-clinical and clinical PK/PD group. Actually I am almost sure as to
who was the hiring manager when you went to New London for that job
interview and what position it was. You know it is a small world, both on
this board and in the pharma industry. |
s**********r 发帖数: 330 | 7 I don't know how to answer this. PK/PD's role is very important in DMPK,
and normally their jobs are quite secure. But that's my impression. To my
knowledge, there are quite a few famous IDs on this board, maybe they can
post their 2 cents??
【在 c*******g 的大作中提到】 : 那就是pharm industry 里面的it民工? : 怎么感觉it民工抱怨的多 : pk pd抱怨的人少呢? : 难道因为样本太少了? : : their
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c*******g 发帖数: 695 | 8
my
~~~~~~~~~~~~~~I believe so. But what about
their
career development?
【在 s**********r 的大作中提到】 : I don't know how to answer this. PK/PD's role is very important in DMPK, : and normally their jobs are quite secure. But that's my impression. To my : knowledge, there are quite a few famous IDs on this board, maybe they can : post their 2 cents??
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s**********r 发帖数: 330 | 9 Nothing special, just like other scientists, taking on a project, working on
it; then another then another... But almost everyone in PK/PD area has a
doctor's degree so the entry level is senior scientist. Then moving up
gradually then after xx years if they are still here finally daughter-in-law
becomes mother-in-law. Has the potential to get on the manager track, but
it's everybody's game.
【在 c*******g 的大作中提到】 : : my : ~~~~~~~~~~~~~~I believe so. But what about : their : career development?
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c****m 发帖数: 67 | 10 PK=pharmacokinetics and what is PD? Pharmacodynamics or pharmaceutical
development?
PK involoved many bench work, mostly conducted by low level technicians.
Pharmaceutical science (development) bridges dosage form, PK/DM performance,
manufacture engineering, CMC and et al. It is pivitol department for
pharmaceutical company. As to bench work, there is not as much as analytical
or synthesis.
Without either of these two groups, there is no drug. |
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w*****n 发帖数: 980 | 11 那就给点建议吧
to
【在 s**********r 的大作中提到】 : It really doesn't matter what I am doing everyday. I do work closely with : both pre-clinical and clinical PK/PD group. Actually I am almost sure as to : who was the hiring manager when you went to New London for that job : interview and what position it was. You know it is a small world, both on : this board and in the pharma industry.
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w*****n 发帖数: 980 | 12 pharmacodynamics
one is what does body do to the drug.
one is what does drug do to the body.
performance,
analytical
【在 c****m 的大作中提到】 : PK=pharmacokinetics and what is PD? Pharmacodynamics or pharmaceutical : development? : PK involoved many bench work, mostly conducted by low level technicians. : Pharmaceutical science (development) bridges dosage form, PK/DM performance, : manufacture engineering, CMC and et al. It is pivitol department for : pharmaceutical company. As to bench work, there is not as much as analytical : or synthesis. : Without either of these two groups, there is no drug.
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d******m 发帖数: 199 | 13 我也一直很好奇。实在是因为满视野的都是他们在找人。 |
I*****M 发帖数: 622 | 14 说的是PK/PD modeling吧?
分析数据,建模型拟合,然后根据模型改进drug,可以减少drug development的成本。
至于boring不boring,每个人喜欢的东西不一样,自然有人乐在其中。 |
R*j 发帖数: 248 | 15 Preclinical里做PK/PD很少,尤其在传统的大公司,主要是因为PK是一个部门,PD是另
一个部门,是Pharmacologist作,所以很难协同,想想一个学校里不同系,或者一个系
里不同实验室之间的横向联系的困难。
Clinical一般是在后期才有PK/PD,一个万人R&D的大公司也就是寥寥几个人在作
modeling.
【在 c*******g 的大作中提到】 : 天天develop模型? : 是不是根程序员差不多了 : 还是需要bench work的? : industry的朋友讲一下
|
s**********r 发帖数: 330 | 16 What is the defining moment between preclinical and clinical in your company
? In my company it is when the compound reaches Candidate Alert Notice (CAN
). FIH will take place shortly after. We have a very well staffed PK/PD
group supporting pre-clinical studies using animal model. Otherwise it will
break my heart that thousands of rats or mice got murdered by suffocation
without even been analyzed using those PK/PD modeling :). Clinical PK/PD
group supports clinical studies from the very b
【在 R*j 的大作中提到】 : Preclinical里做PK/PD很少,尤其在传统的大公司,主要是因为PK是一个部门,PD是另 : 一个部门,是Pharmacologist作,所以很难协同,想想一个学校里不同系,或者一个系 : 里不同实验室之间的横向联系的困难。 : Clinical一般是在后期才有PK/PD,一个万人R&D的大公司也就是寥寥几个人在作 : modeling.
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c********g 发帖数: 1106 | 17 i like this. quite sharp.
their
【在 s**********r 的大作中提到】 : They don't do bench work...Everyday sitting at their desks in front of a : computer, sometimes in meetings, sometimes in training classes. To me their : job is quite boring but maybe they are enjoying themselves.
|
w*****n 发帖数: 980 | 18 hehe, up
【在 c********g 的大作中提到】 : i like this. quite sharp. : : their
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R*j 发帖数: 248 | 19 Preclinical PK一般在lead optimization阶段开始,此时有几个chemical serial,动
物PK主要是粗略得看看drug exposure,half life, etc.,用这些数据去指导lead
optimization. lead optimization这个阶段要面临成百上千的化合物,是不可能都上
PD的,PK/PD modeling有的话,也是给几个非常有希望的化合物作一下。
有些公司会有development preclinical PK,主要做一些definitive PK,详细看看ADME
, 也看看formulation对PK的影响......
Clinical PK 一期是纯PK,后期会有一些PK/PD modeling,做这个的人背景很杂,MD,
PharmD, statistician.一个project要很多不同职能的人参加进来,是team work.
company
CAN
will
【在 s**********r 的大作中提到】 : What is the defining moment between preclinical and clinical in your company : ? In my company it is when the compound reaches Candidate Alert Notice (CAN : ). FIH will take place shortly after. We have a very well staffed PK/PD : group supporting pre-clinical studies using animal model. Otherwise it will : break my heart that thousands of rats or mice got murdered by suffocation : without even been analyzed using those PK/PD modeling :). Clinical PK/PD : group supports clinical studies from the very b
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T******y 发帖数: 14506 | 20 PK/PD modeling难不难学?考虑改方向去读两年薄厚再出来找工作,不知道值不值。 |
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c********g 发帖数: 1106 | 21 简单,煞是简单。
【在 T******y 的大作中提到】 : PK/PD modeling难不难学?考虑改方向去读两年薄厚再出来找工作,不知道值不值。
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w*****n 发帖数: 980 | 22 楼上是大牛啊,hehe
【在 c********g 的大作中提到】 : 简单,煞是简单。
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c***a 发帖数: 38 | 23 In my company, most of the clinical PK/PD guys are also compound directors
for the DMPK, which is a pretty good career path.
【在 c*******g 的大作中提到】 : : my : ~~~~~~~~~~~~~~I believe so. But what about : their : career development?
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c********g 发帖数: 1106 | 24 which company?
【在 c***a 的大作中提到】 : In my company, most of the clinical PK/PD guys are also compound directors : for the DMPK, which is a pretty good career path.
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T******y 发帖数: 14506 | |
p*5 发帖数: 16204 | 26 看什么方向
Modeling ans simulation是不需要beanch work的,data都是别人提供的。
ADME 或者 pk/pd sample assay的还是不少bench work的。 |
y***n 发帖数: 27 | 27 也好奇来问一下,
1. PK/PD modeling和biostat的相比,哪个pay的高?比如biostat entry level 一般
pay 8-9w,pk/pd呢?
2.stat phd,with extensive experience in winnonlin,nonmem,在这个行业里是否
不如pk/pd本专业的popular?
因为同学都是做biostat或者marketing的,这个方向缺乏了解,希望版上的牛人们指点
指点 |
y***n 发帖数: 27 | 28 不算简单吧
【在 c********g 的大作中提到】 : 简单,煞是简单。
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i**f 发帖数: 1195 | |