g********d
发帖数: 4174 | 1 Scientists in Denmark are reporting that they are just months away from
unveiling a breakthrough treatment that could functionally cure HIV, reports
U.K. newspaper the Telegraph.
The researchers are currently conducting clinical trials of a "novel
strategy" that strips the HIV virus from human DNA, allowing the immune
system to permanently destroy the virus. The treatment involves releasing
the HIV virus from "reservoirs" it forms within DNA, bringing the virus to
the surface of the cell. Researchers contend that once the virus has been
brought to the cell's surface, the body's immune system — boosted by a
vaccine — can kill the HIV.
Lead researchers studying the treatment told Telegraph that initial signs
are "promising."
"I am almost certain that we will be successful in releasing the reservoirs
of HIV," said Dr. Ole Søgaard, a senior researcher at Denmark's Aarhus
University Hospital. "The challenge will be getting the patients' immune
system to recognize the virus and destroy it. This depends on the strength
and sensitivity of individual immune systems."
The Telegraph reports that 15 patients are currently enrolled in clinical
trials for the treatment, and if they are successfully cured of HIV, the
treatment will be rolled out on a larger scale, administered in combination
with an immune-system booster.
The treatment uses HDAC inhibitors, which are most commonly used to treat
cancer, according to the Telegraph. The Danish researchers are experimenting
with a particularly potent HDAC inhibitor called Panobinostat.
The technique has already been proven effective in laboratory trials,
including those that use human cells, reports the Telegraph. British
scientists are currently researching a similar treatment method, but have
yet to advance to the clinical trials stage of the process.
Danish researchers are also optimistic that if these human trials prove
effective, the treatment could be made available on a large scale at an
affordable cost, providing an alternative to gene therapy, the costly and
complex treatment that aims to make a patient's immune system resistant to
HIV.
http://www.hivplusmag.com/case-studies/research-breakthroughs/2 | t*******e
发帖数: 2113 | 2 不懂科學。是不是到了人來實驗的步驟，就說明這的確是breakthrough？
reports
【在 g********d 的大作中提到】
: Scientists in Denmark are reporting that they are just months away from
: unveiling a breakthrough treatment that could functionally cure HIV, reports
: U.K. newspaper the Telegraph.
: The researchers are currently conducting clinical trials of a "novel
: strategy" that strips the HIV virus from human DNA, allowing the immune
: system to permanently destroy the virus. The treatment involves releasing
: the HIV virus from "reservoirs" it forms within DNA, bringing the virus to
: the surface of the cell. Researchers contend that once the virus has been
: brought to the cell's surface, the body's immune system — boosted by a
: vaccine — can kill the HIV.
| g********d
发帖数: 4174 | 3 15个病人应该是phase I clinical trial,也就是第一步用人的试验，后面还有phase
II, phase III, 没看过数据不了解这个药为什么在phase I 就被称为breakthrough。
【在 t*******e 的大作中提到】
: 不懂科學。是不是到了人來實驗的步驟，就說明這的確是breakthrough？
:
: reports
| t*******e
发帖数: 2113 | 4
醬紫。這個藥物不需要動物實驗？還是說已經通過動物實驗的檢驗？
【在 g********d 的大作中提到】
: 15个病人应该是phase I clinical trial,也就是第一步用人的试验，后面还有phase
: II, phase III, 没看过数据不了解这个药为什么在phase I 就被称为breakthrough。
| g********d
发帖数: 4174 | 5 已經通過動物實驗的檢驗
【在 t*******e 的大作中提到】
:
: 醬紫。這個藥物不需要動物實驗？還是說已經通過動物實驗的檢驗？
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