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发帖数: 578 | 1 最近发表的一篇文章，发现运动前服用ibuprofen可能会造成一定肠道损伤
Med Sci Sports Exerc. 2012 Dec;44(12):2257-62.
Aggravation of exercise-induced intestinal injury by Ibuprofen in athletes.
Abstract
INTRODUCTION:
Nonsteroidal anti-inflammatory drugs are commonly used by athletes to
prevent anticipated exercise-induced pain, thereby putatively improving
physical performance. However, these drugs may have potentially hazardous
effects on the gastrointestinal (GI) mucosa during strenuous physical
exercise. The aim of the current study was to determine the effect of oral
ibuprofen administration before exercise on GI integrity and barrier
function in healthy individuals.
METHODS:
Nine healthy, trained men were studied on four different occasions: 1) 400
mg ibuprofen twice before cycling, 2) cycling without ibuprofen, 3) 400 mg
ibuprofen twice at rest, and 4) rest without ibuprofen intake. To assess
small intestinal injury, plasma intestinal fatty acid binding protein (I-
FABP) levels were determined, whereas urinary excretion of orally ingested
multisugar test probes was measured using liquid chromatography and mass
spectrometry to assess GI permeability.
RESULTS:
Both ibuprofen consumption and cycling resulted in increased I-FABP levels,
reflecting small intestinal injury. Levels were higher after cycling with
ibuprofen than after cycling without ibuprofen, rest with ibuprofen, or rest
without ibuprofen (peak I-FABP, 875 ± 137, 474 ± 74, 507 ± 103, and 352
± 44 pg·mL, respectively, P < 0.002). In line, small intestinal
permeability increased, especially after cycling with ibuprofen (0-2 h
urinary lactulose/rhamnose ratio, 0.08 (0.04-0.56) compared with 0.04 (0.00-
0.20), 0.05 (0.01-0.07), and 0.01 (0.01-0.03), respectively), reflecting
loss of gut barrier integrity. Interestingly, the extent of intestinal
injury and barrier dysfunction correlated significantly (RS = 0.56, P < 0.
001).
CONCLUSION:
This is the first study to reveal that ibuprofen aggravates exercise-induced
small intestinal injury and induces gut barrier dysfunction in healthy
individuals. We conclude that nonsteroidal anti-inflammatory drugs
consumption by athletes is not harmless and should be discouraged.
http://www.ncbi.nlm.nih.gov/pubmed/22776871 |
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