S***A
发帖数: 40 | 1 5th SABPA/ACS Chemistry Symposium
DATE: Friday, April 10, 2015
TIME: 4:45 – 5:45 PM Registration, Networking and
Light dinner
5:45 – 6:30 PM Dr. Shifeng Pan, “Discovery
of porcupine inhibitors targeting Wnt signaling in cancer”
6:30 – 7:15 PM Professor John F. Hartwig,
“Metal-Mediated and Metal-Catalyzed Incorporation of Fluorine into Aromatic
Molecules”
PLACE: Knobbe Martens Olson & Bear LLP
12790 El Camino Real, San Diego, CA 92130
Online http://sabpa.org/html/acschem5/
registration: By Thursday, April 9, 2015
Dr. Shifeng Pan, Ph.D., Director of Medicinal Chemistry, Genomics Institute
of the Novartis Research Foundation (GNF)
Dr. Pan currently serves as Director of Medicinal Chemistry at the Genomics
Institute of the Novartis Research Foundation (GNF), where he is responsible
for medicinal chemistry efforts at the Institute. He leads a team of ~80
chemists who are working to discover small molecule therapeutics and drug
conjugates across multiple disease areas. Since joining GNF in 1999 as one
of the founding chemists, he has directly contributed to five clinical
candidates. Among those, LDE225 (sonidegib), a smoothened antagonist, is in
registration for advanced basal cell carcinoma; BAF312 (siponimod), a S1P1/5
agonist, is in Phase 3 clinical trials for secondary progressive multiple
sclerosis and Phase 2 clinical trials for polymyositis and dermatomyositis;
LGX818 (encorafenib), a B-Raf inhibitor, is in Phase 3 clinical trials for
melanoma; and WNT974, a first-in-class Porcupine inhibitor, is currently in
Phase I trials for solid tumors. In 2010, he received the prestigious VIVA
award as a Novartis Leading Scientist. Dr. Pan received his Ph.D. in organic
chemistry from New York University and B.S. in chemistry from Fudan
University in Shanghai, China.
Professor John F. Hartwig, Ph.D., Henry Rapoport Professor of Chemistry, U.C
. Berkley
John Hartwig was raised near Schenectady New York, received his A.B. from
Princeton University, obtained his Ph.D. from U.C. Berkeley with Bob Bergman
and Richard Andersen, and conducted a postdoctoral fellowship at MIT with
Stephen Lippard. In 1992 he began his independent career at Yale University
and became the Irenée P. DuPont Professor in 2004. In 2006, he moved to
the University of Illinois where he was the Kenneth L. Rinehart Jr.
Professor of Chemistry. In 2011, he returned to U.C. Berkley as the Henry
Rapoport Professor. Professor Hartwig's research focuses on the discovery
and understanding of new reactions catalyzed by transition metal complexes.
In addition to C-H bond functionalization with main group reagents that is
the subject of his lecture, he is well known for contributions to cross-
coupling chemistry that form arylamines, aryl ethers, aryl sulfides, and a-
aryl carbonyl compounds. He is the author of the textbook “Organotransition
Metal Chemistry: From Bonding to Catalysis.” He has received awards,
including an A.C. Cope Scholar Award, the ACS award in Organometallic
Chemistry, the H.C. Brown Award for Synthetic Methods, the Nagoya Gold Medal
, and the Willard Gibbs Medal, and he was elected to the National Academy of
Sciences in 2012. |
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