g********n
发帖数: 251 | 1 data set have variables：subject，day，pk_concentration，dose，pd_response.
emax model using proc nlmixed；
parms s2p=xx s2e=xx emax=xx；
num=emax*dose；
den=ed50+dose；
model pd_response ～normal （（num/den）+subject，s2e）；
random sub ～normal（0，s2p）subject=subject；
run；
现在要做pk/pd modelling，怎么样把day 和pk_concentration 放到model 里呀？沒做
过pk/pd modelling.有没有人知道的，谢谢啦 |
w*******9
发帖数: 1433 | 2 day and pk_concentration will enter your model somewhere in the num and den.
Could you please give us the nonlinear function you use? That way I could
help you out. By the way, are you sure the day will be in the PD model? |
g********n
发帖数: 251 | 3 多谢楼上的
i am thinking to replace dose with pk_concentration，实在想不到有什么别的法
了，把day and pk_conc put in the model 是老板的原活，因为each subject has
two visits on the dame day，想看看这两visit perform similarly？至于nonlinear
function 说实话我也不知道，以前沒用过 |
w*******9
发帖数: 1433 | 4 I have done a simulation study of the PK model so I know a little bit, but
never did the model fitting.
If you only want the PD parameters, things will be easier. Emax model
assumes
PD = E0 + (Emax-E0)/(1+EC50/Concentration) + error
here (E0, Emax, EC50) is subject specific and follows a joint normal model.
If you want to know more, see
http://www4.stat.ncsu.edu/~davidian/webinar.pdf
nonlinear
【在 g********n 的大作中提到】
: 多谢楼上的
: i am thinking to replace dose with pk_concentration，实在想不到有什么别的法
: 了，把day and pk_conc put in the model 是老板的原活，因为each subject has
: two visits on the dame day，想看看这两visit perform similarly？至于nonlinear
: function 说实话我也不知道，以前沒用过
|
g********n
发帖数: 251 | |
