N**D
发帖数: 2885 | 1 【 以下文字转载自 WaterWorld 讨论区 】
发信人: NYPD (New York, Pursuit of Dream), 信区: WaterWorld
标 题: Antibody Kills 91% of HIV Strains
发信站: BBS 未名空间站 (Thu Jul 8 16:02:53 2010, 美东)
from wsj
In a significant step toward an AIDS vaccine, U.S. government scientists
have discovered three powerful antibodies, the strongest of which
neutralizes 91% of HIV strains, more than any AIDS antibody yet discovered.
Looking closely at the strongest antibody, they have detailed exactly what
part of the virus it targets and |
N**D
发帖数: 2885 | 2 重大突破啊同学们！
【在 N**D 的大作中提到】
: 【 以下文字转载自 WaterWorld 讨论区 】
: 发信人: NYPD (New York, Pursuit of Dream), 信区: WaterWorld
: 标 题: Antibody Kills 91% of HIV Strains
: 发信站: BBS 未名空间站 (Thu Jul 8 16:02:53 2010, 美东)
: from wsj
: In a significant step toward an AIDS vaccine, U.S. government scientists
: have discovered three powerful antibodies, the strongest of which
: neutralizes 91% of HIV strains, more than any AIDS antibody yet discovered.
: Looking closely at the strongest antibody, they have detailed exactly what
: part of the virus it targets and
|
a***a
发帖数: 40617 | 3 最后一句很汗
【在 N**D 的大作中提到】
: 重大突破啊同学们！
|
y*****1
发帖数: 73 | |
s******y
发帖数: 28562 | 5 I just read this on my cellphone.
It is likely an antibody against a conserved region of the virus.
Such a concept exists for a long time but I am suprised it took so
long to produce something like that for HIV
【在 N**D 的大作中提到】
: 重大突破啊同学们！
|
a***a
发帖数: 40617 | 6 之前还有个号称治aids的发了nature biotechnology，不知道是不是就是这个
【在 s******y 的大作中提到】
: I just read this on my cellphone.
: It is likely an antibody against a conserved region of the virus.
: Such a concept exists for a long time but I am suprised it took so
: long to produce something like that for HIV
|
s******y
发帖数: 28562 | 7 Actually it is not that difficult as we may think
For example we can figure out the binding pocket of the antibody and then
either make it a monoclonal mini-antibody for injection or make the DNA
for generation of such a antibody and clone it into our bone marrow stem
cells
【在 a***a 的大作中提到】
: 最后一句很汗
|
a***a
发帖数: 40617 | 8 单抗可行，第二个基本现阶段是扯，是科幻小说
【在 s******y 的大作中提到】
: Actually it is not that difficult as we may think
: For example we can figure out the binding pocket of the antibody and then
: either make it a monoclonal mini-antibody for injection or make the DNA
: for generation of such a antibody and clone it into our bone marrow stem
: cells
|
h********n
发帖数: 4079 | 9 最后一段都很汗.
【在 a***a 的大作中提到】
: 最后一句很汗
|
s******y
发帖数: 28562 | 10 How come? Such thing can be done in vitro in a rather straight forward way.
Can we transfect the donor bone marrow cells and then go for immuno
stimulate
and selection and finally select for the memory B cell that express that
particular antibody and put it back to the donor's body?
I mean there will be a lot of work invovled but in theory that should be
doable
right?
【在 a***a 的大作中提到】
: 单抗可行，第二个基本现阶段是扯，是科幻小说
|
|
|
a***a
发帖数: 40617 | 11 thousands of things can be done in vitro.BUT....
【在 s******y 的大作中提到】
: How come? Such thing can be done in vitro in a rather straight forward way.
: Can we transfect the donor bone marrow cells and then go for immuno
: stimulate
: and selection and finally select for the memory B cell that express that
: particular antibody and put it back to the donor's body?
: I mean there will be a lot of work invovled but in theory that should be
: doable
: right?
|
p*****m
发帖数: 7030 | 12 其实都用不了这么麻烦 直接在造血干细胞里面突变掉CCR5然后原封不动的给患者注射回
去就行了 也不需要考虑哪个antibody好用 呵呵
其实拿bone marrow cell出来转了基因然后种回去已经做了n个临床实验了 效果不好说
但是至少是feasible的
【在 s******y 的大作中提到】
: How come? Such thing can be done in vitro in a rather straight forward way.
: Can we transfect the donor bone marrow cells and then go for immuno
: stimulate
: and selection and finally select for the memory B cell that express that
: particular antibody and put it back to the donor's body?
: I mean there will be a lot of work invovled but in theory that should be
: doable
: right?
|
K******S
发帖数: 10109 | 13 "Researchers screened 25 million of his cells
to find 12 that produced the antibodies. Now the trick will be for
scientists to develop a vaccine or other methods to make anyone's body
produce them."
now they will keep that man as national treasure.
【在 N**D 的大作中提到】
: 重大突破啊同学们！
|
W****C
发帖数: 1937 | 14 the strongest of which neutralizes 91% of HIV strains，more than any AIDS
antibody yet discovered.
ｃｏｎｔｒｏｌ做得不好， 之前的抗体是９０％呢还是１％呢？ |
s*****3
发帖数: 41 | 15 I just read this article. It seems pretty good.
In the last figure, they compare the neutralization potency and breadth of
the new antibody VRC01 with that of b12, a well-known broadly neutralizing
Ab against CD4 binding site of gp120. Under IC50 <50 ug/ml, VRC01 can
neutralize 91% of 190 Env pseudoviruses, whereas b12 can only neutralize 41%.
One question about the paper is that they design a molecule, RSC3, that
keeps the antigenicity of CD4 binding site of gp120 whereas remove the
antigenicit |
O******e
发帖数: 4845 | 16 Or you should say: thousands of things were claimed to happen in vitro....
【在 a***a 的大作中提到】
: thousands of things can be done in vitro.BUT....
|
