w*******h
发帖数: 25 | 1 我的FOLATE Test, 值是18.06 ng/mL, 不知道是什么意思, 也不知道有没有一个标准,
有谁知道的帮忙看看, 谢谢. |
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b*******n
发帖数: 12321 | 2 Is it possible to get 1 isomer of the mono-NHS-folate? It doesn't matter
alpha or gamma NHS ester, but don't
want a mixture of the two.
Thank you in advance! |
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M*****8
发帖数: 17722 | 3
"The FDA ‘protects’ the big drug companies and are subsequently rewarded,
and using the government’s police powers they attack those who threaten the
big drug companies. People think that the FDA is protecting them. It isn’t
. What the FDA is doing and what the public thinks it is doing are as
different as night and day."
–-- Dr. Herbert Ley – Former U.S. FDA Commissioner
https://www.nytimes.com/1977/03/14/archives/demoralized-fda-struggles-to-
cope-some-top-jobs-remain-unfilled-at.html
"In rec... 阅读全帖 |
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h********n
发帖数: 4079 | 4 When I just came to US I did folate-targeted drug delivery. We chemically linked toxin to folate with some chemistry that the linker is easier to break in cells. Some cancer cell overexpress folate receptor on cell surface so the folate-toxin will enter cell by endocytosis. However it is technically hard to get the folate-toxin break efficiently to kill cells.
I transferred from Purdue after 1.5 years for other reason. You can check Philip Low at chem dept at Purdue. Also check endocyte.com |
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S*****o
发帖数: 131 | 5 看你怎么消化吸收了 - below is from wikipedia
Spinach has a high nutritional value and is extremely rich in antioxidants,
especially when fresh, steamed, or quickly boiled. It is a rich source of
vitamin A (and especially high in lutein), vitamin C, vitamin E, vitamin K,
magnesium, manganese, folate, betaine, iron, vitamin B2, calcium, potassium,
vitamin B6, folic acid, copper, protein, phosphorus, zinc, niacin, selenium
and omega-3 fatty acids. Recently, opioid peptides called rubiscolins have
also been ... 阅读全帖 |
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a*********n
发帖数: 2526 | 6 Cardiovascular disease risk factors and diet of Fulani pastoralists of
northern Nigeria1,2,3
Robert H Glew,
Margaret Williams,
Carole A Conn,
Samuel M Cadena,
Michael Crossey,
Seline N Okolo, and
Dorothy J VanderJagt
+ Author Affiliations
1From the Department of Biochemistry and Molecular Biology, School of
Medicine, and the Department of Individual Family and Community Education,
School of Education, University of New Mexico, Albuquerque; the Department
of Paedia... 阅读全帖 |
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f******I
发帖数: 769 | 7
balanced diet and routine exercise and adequate rest are good for overall
health, if you are concerned about folate intake during pregnancy, most of
flour is folic acid fortified, or you can get over the counter folic acid at
400 mcg a day, 1mg a day you'd need a prescription, leafy vegetables are
rich in folate, and some breakfast cereals are enriched with folate as well, |
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J****0
发帖数: 229 | 8 来自主题: NextGeneration版 - 缺铁补叶酸？ 贫血的话，妇女一般是缺铁，但是小细胞贫血的也有FOLATE的缺乏，除非真的是验血验
到缺铁，否则补FOLATE也是补贫血的。贫血不一定都是缺铁，有缺FOLATE,B12的 |
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g*****j
发帖数: 1211 | 9 Doctors treat the patient, not the lab results. The most likely diagnosis
is deficiency in B12 or folate or both and glucose intolerance. However, it
doesn't necessarily mean you don't have enough B12/folate in your diet or
you have diabetes already. You need to work with you doctor to get down to
the bottom of your problem. Either condition can have devastating
consequence, and either condition can be the result of other problems. |
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r********s
发帖数: 114 | 10 姐妹们，我现在怀孕8周半，之前一直吃ob开的维生素，今天才看到他的成分是folate
1mg include folic acid 400mcg，那就是说我每天只吃了400MCG的叶酸，是不是太少
了呀，还是FOLATE 可以转化成FOLIC ACID呢,正好是最关键的一个月，心里好怕，请知
道的姐妹们给我些建议吧，多谢了。 |
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d********n
发帖数: 1013 | 11 别忘了,平时你还吃饭吃菜呢,里面也有folate的.
folate |
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e*******n
发帖数: 872 | 12 其他检查就做了几个，什么致畸五项 蛋白质C s 还有抗心磷脂、nuclear抗体 染色体
也不给做 说流产三次以上才给查 目前就知道METHR C677T和A1298C基因变异,跟楼下说
的一样，one copy of each。看完后医生还给开了folic acid，没有提到folate跟
folic acid的事情，我倒是网上看到一个帖子提到过，还没往心里去，楼上folate跟
folic acid是医生告知的吗？下次再去换一家医院看看，目前这家不太靠谱啊 |
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O******e
发帖数: 4845 | 13 http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.2472.htm
Intraoperative tumor-specific fluorescence imaging in ovarian cancer by
folate receptor-a targeting: first in-human results
Abstract:
The prognosis in advanced-stage ovarian cancer remains poor. Tumor-speci
fic intraoperative fluorescence imaging may improve staging and debulkin
g efforts in cytoreductive surgery and thereby improve prognosis. The ov
erexpression of folate receptor-a (FR-a) in 905% of epithelial ovarian
cancers prom... 阅读全帖 |
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b**s
发帖数: 589 | 14 It's not better than a fluoresence tagged antibody and Folate receptors is
not unique for tumor cell.
One thing I was confused that Folate receptors are expressed on the cell
surface, how can the nano particles enter the cell?
wide
the
star-like
different
to
Biomedical
two
single-stranded,
of |
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r*****1
发帖数: 805 | 15 My CCS protocol:
P.S.：多有重复，谨防遗漏，仅供参考。
Screening test: General—Lipid profile/ multi-vitamin; Elderly—DEXA scan&
Calcium& VitD/ Colonscopy or FOBT/ vaccination; F-- >18yo Pap smear; >50yo
Mammogram; reproductive age- folate; menopause- Lipid/DEXA/FOBT; M-- >50yo
PSA; sickle cell dz child-prophylaxis w penicillin till 5yo, CF-prophylaxis
w Abx
Prophylaxis: Pantoprazole, pneumatic compression stocking;
Acute abd w perforation: triple Abx- Gentamycin/ Ampicillin/
Metronidazole (口诀：阿扁举旗庆国庆)
E... 阅读全帖 |
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z******8
发帖数: 844 | 16 ☆─────────────────────────────────────☆
rhcrc11 (Rebel) 于 (Thu May 15 00:13:42 2014, 美东) 提到:
Step3考场壮烈回来。第一天挺累人，最后一个block甚至做到有心无力状，看着题反应
不过来，导致来不及做完。非常没有信心能否通过。所以match之前先考Step3的童鞋，
需要考前调整生物钟，坚持锻炼，提高耐力。
MCQ没有资格说，CCS有一点小感受，拿出来分享下。大家请轻拍砖。
复习资料：
UW 52 online cases : 基础。最好复习早起找高手一起过一遍，尽快摸熟软件，进入
状态。第二遍找一位水平相近童鞋过一遍，不断总结protocol. 考前迅速做一遍，熟练
运用protocol.
UW 41 offline cases: 我当时和partner每个case仔细做一遍，虽然不像online有反馈
，但对练临床思维，补充protocol非常有帮助。最后考试与41 case有异曲同工之处，
遇到复杂case也不慌神。
CD 6 cases： 最后再熟悉下考试软件。与UW相近，但... 阅读全帖 |
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c*********p
发帖数: 3217 | 19 Food for men 1: Tomatoes
Food for men 2: Blueberries
Food for men 3: Brazil nuts
Food for men 4: Broccoli
Food for men 5: Oysters
Food for men 6: Whole grains
Food for men 7: Eggs
Food for men 8: Pomegranate juice
Food for men 9: Garlic
Food for men 10: Salmon
Food for men 1: Tomatoes
Tomatoes are possibly one of the best "superfoods" around, and the popular
fruit has particular benefits for men. Studies
have suggested that the lycopene found in tomatoes may reduce risk of
colorectal cancer, low... 阅读全帖 |
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l**********r
发帖数: 240 | 20 Health - Reuters
B-Vitamin Problems May Cause Depression in Some
By Alison McCook
NEW YORK (Reuters Health) - New findings suggests that some people with
depression might have problems metabolizing the B vitamin folate -- supporting
the idea that supplements could help ward off the condition, researchers say.
Investigators in Norway found that depression occurred more commonly in people
who had high levels of the amino acid homocysteine in their blood, and in
those who carried a form of a gene t |
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E******r
发帖数: 40 | 21 MCH是看红细胞里面的血球蛋白含量的。MCH升高表明有可能缺乏维生素B12或叶酸(folate
)，
去买复合维生素给他每天一粒。
LDL是所谓的“坏的”lipid，越低越好(不象HDL，高点好)，控制你老公的油脂摄入，不
要大鱼大肉，注意锻炼。
TSH的确很高，可能是甲状腺低功，(他是否怕冷，虚胖，不喜欢动？)估计医生会给他开
甲状腺素的，如果他T3，T4也很低的话。
me |
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l*h
发帖数: 4124 | 22 to be more specific, at this time, if you don't want to go the palliative
path, you should urge your dad's oncologist to consider the following
regimens:
1. a microtubule inhibitor + a platinum derivative or
2. a microtubule inhibitor + a platinum derivative + a conventional
alkylating agent
folate antimetabolites can also be considered but I would not place them
ahead of the above two options.
you should be very cautious to consider bevacizumab. remember, your dad is ~
65 yo. bevacizumab just c... 阅读全帖 |
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M****0
发帖数: 877 | 23 If anemia has been diagnosed, it should be further worked up to identify the
underlying cause. I am surprised that your fmaily doctor did not order any
test.
How low is the hemoglobin level?
There are other indexes on the complete blood cell count test, such as MCV,
MCH and MCHC. Are those within normal limit or not?
Any check up for iron (very rare for a male patient), folate and vit B12?
Neurological problems can cause anemia but anemia might cause dizziness or
syncope. If hemoglobin level is ... 阅读全帖 |
|
az
发帖数: 16686 | 24 Foods high in folic acid
Food Folic Acid μg/Serving
Dietary Folate Equivalents*(DFE)
Ready-to-eat breakfast cereal 100 – 400/serving; read labels
Enriched wheat tortilla 98 / one 8” tortilla
Whole wheat tortilla 24 / one 8” tortilla
Enriched white bread 39 / slice
Enriched pasta, cooked 92 / half cup
Whole wheat bread 14 / slice
Whole wheat pasta 23 / half cup
Lentils, cooked 180 / cup
Black-eyed peas, dried, cooked 105 / half cup
Pinto beans or chickpeas, cooked |
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c**********0
发帖数: 836 | 27 我的是prenate elite,医生开的，不知道有没有：
Ingredients:
Elemental Iron (carbonyl iron) 90 mg, Biotin 30 mcg, Pantothenic acid
(calcium pantothenate, USP) 6 mg, Calcium (calcium carbonate, USP) 200
mg, Copper (cupric oxide) 2 mg,Zinc (zinc oxide, USP) 15 mg, Folate (L-
methylfolate as Metafolin® 600 mcg) (folic acid, USP 400 mcg) 1 mg,
Vitamin D3 (cholecalciferol) 400 IU, Vitamin E (dl-alphatocopheryl
acetate) 10 IU, Vitamin C (ascorbic acid) 120 mg, Vitamin B1 (thiamine
mononitrate) 3 mg, Vitamin B2 (ri |
|
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k*****i
发帖数: 298 | 29 normal recommendation is 600-800
If you eat enough leaf veggies, it should be ok. Or go to the market & get
additional folate supplement pills. Don't worry too much about the exact
dosage. |
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l***o
发帖数: 578 | 30 In theory, 400 microgram daily is enough if you have no risk factor.
Prenatal vitamin has enough folate for normal pregnancy. |
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x**t
发帖数: 748 | 31 Costoco有Nature Made Prenatal Multi + DHA， Liquid Softgel。现在吃也不晚，这
个东西别担心太多。
folate |
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s********n
发帖数: 616 | 32 好像说身体一天最多就吸收这么多叶酸，吃多了没用，不吸收都流掉了
folate |
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a******n
发帖数: 91 | 33 刚刚做了第二个trimester screen,就是查down syndrome, 还有什么spine问题，医生
说我的spine bifida 的比例是1/150. 属于negative, 但是有点高，说下个星期去做超
声波确认。各位美妈们有类似的经历吗？网上查了说怀孕28天的时候spine就长好了，
我是意外孕，所以怀孕第5周才开始吃folate, 不知道有没有原因，现在好担心啊～～
～～～～～～～～ |
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y*****t
发帖数: 264 | 34 Most likely it is iron deficient anemia, Your Pedi Dr. want to r/o other
reasons( B12, folate deificiency) and want to do iron study to confirm IDA
and for follow-up
For IDA, one year old baby is typical ( when switch to whole milk) fomular
uasually are iron rich. The treatment is very simply , give liquid iron and |
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n****8
发帖数: 4141 | 35 Kellymom上的，
In the second year (12-23 months), 448 mL of breastmilk provides:
29% of energy requirements
43% of protein requirements
36% of calcium requirements
75% of vitamin A requirements
76% of folate requirements
94% of vitamin B12 requirements
60% of vitamin C requirements
– Dewey 2001 |
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p*******e
发帖数: 480 | 36 一般的情况，用综合维生素就可以。
如果想提高一下精子质量，可以吃fertility blend for men. 亚麻上可以买到。
2颗一天。主要成份是VC,VE,VB6 VB12,FOLATE ZINC SELENIUM.再加了点绿茶，精胺酸
等。
如果再想增加一点精子活性。可在此基础上再用淫羊藿每天当茶叶泡茶喝。 |
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c******r
发帖数: 1450 | 37 New Chapter的folate就是叶酸。 |
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r*********d
发帖数: 12 | 38 先抱抱mm
其他检查都做了吗？如果确定是这两个基因变异引起的，那mm不要着急，很好解决的，
最重要的一点就是要补充folate，最好是methytetrahydrofolate，注意一定不要是
folic acid！看看你吃的prenatal vitamin，里面的叶酸如果是标注的folic acid，那
马上停掉，MTHFR C677T mutaion会让你的身体无法代谢synthetic folic acid，而且
不能有效吸收食物里的天然叶酸，所以就可能造成流产。
你再仔细看看你的基因检测报告，这两个突变是homo还是heterozygous mutation（就
是一个还是两个copy的变异基因），如果是两个的话，不管它是不是最终造成你流产的
原因，你都应该停止含folic acid的supplement |
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k***o
发帖数: 259 | 39 我也多次流产，现40岁，医生说年龄和卵子质量可能是重要因素。我是C677T和A1298C基
因变异，heterzygous,也就是one copy of each.但homocystein在正常范围。2012年8-
9周胎停一次（7周有胎心），选择的自然流产。然后一年没试孕，去年一年3次生化流
产(都在4周5天左右）。去年年初第一次生化后约了生殖医生，做了多种检查（输卵管
和宫腔镜没做），除
了这个基因变异，还有一项就是自然杀伤细胞高（我的医生用的lab结果只给总的百分
比，我是40%多）。接下来两次生化我没有见生殖医生，现在有些后悔。
后来回国，我的一个妇科同学建议我吃强的松和低剂量aspirin. 我没立即吃，直到回
来后见了生殖医生，才开始baby aspirin，现在吃了大约20天。医生说，如果发现怀孕
，就立即停止aspirin, 给我注射低分子肝素。并且，为了控制我的免疫，建议我发现
怀孕点滴脂肪乳。
我从第一次胎停后，就一直吃prenatal multivitamin.有时候是new chapter (含
folate），有时候就吃natural made (含folic... 阅读全帖 |
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a******n
发帖数: 91 | 40 刚刚做了第二个trimester screen,就是查down syndrome, 还有什么spine问题，医生
说我的
spine bifina 的比例是1/150. 属于negative, 但是有点高，说下个星期去做超声波确
认。各位
美妈们有类似的经历吗？网上查了说怀孕28天的时候spine就长好了，我是意外怀孕，
所以怀孕第5周才
开始吃folate, 不知道有没有原因，现在好担心啊～～～～～～～～～～ |
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m**k
发帖数: 18660 | 41 http://www.livestrong.com/article/41769-bean-sprouts-nutrition-
Basic Nutrition
The caloric value of the three types ranges from mung sprouts with only 30
calories to lentil sprouts with 106 and soybean sprouts with 122. Their
protein values range from three grams (mung sprouts) to 13 grams (soybean
sprouts). This makes them a good source of protein because three grams
represents 6 percent and 13 grams equals 26 percent of the recommended daily
value (DV). They're all low in total fat and carboh... 阅读全帖 |
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z*********o
发帖数: 1091 | 42 不好意思， 从没买过， 不知行情。谢谢！
请问找Folate名称吗？ |
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l********i
发帖数: 2503 | 43 以下是我的看法
先说客观的一方面：
GALE有三个药：ABSTRAL，NeuVax™和GALE－３０１
ABSTRAL是已经批准的舌下用药的止痛药，类似于INSY的药，销售情况不知道，应该不
错。
NeuVax™是他们主要在开发的药，在三期和二期，离出结果时间还早。这个药是
针对HER２ １－２阳性的乳腺癌病人，是一种疫苗。至于有没有效我不知道，但我自己
不太看好。原因是他们的二期结果原本应该算是失败的，因为和对照组比没有统计学意
义，他们是剔除了HER２ ３阳性的病人才看到有差异的，这不合常理，既然是疫苗，应
该是高表达的更有效才是，至少应该有效。AF以前一直BASH的就是这一点。在这个二期
的基础上才开展的三期。
GALE－３０１是针对FBP的疫苗。FBP是Folate Binding Protein的简称。ECYT那个成功
的药物也是针对这个的，但不是疫苗，是抗体连接药物。这个能否成功不知道，目前在
二期，前段大幅度上涨和这个有关。
再说一下主观方面我的看法：这个公司的管理层很极品，找人PUMP股票后大量抛售，都
是几十万股的，CEO一个人就卖了７５万股，... 阅读全帖 |
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L*****k
发帖数: 3453 | 44 CEO 5分钟前重申， 对此药信心百倍！
明天就是翻倍的节奏
Endocyte Regains Worldwide Rights to Vintafolide
GlobeNewswire
Endocyte, Inc. 1 hour ago
WEST LAFAYETTE, Ind., June 17, 2014 (GLOBE NEWSWIRE) -- Endocyte, Inc., (
ECYT) today announced that it has regained the worldwide rights to
vintafolide in all indications from Merck, known as MSD outside the United
States and Canada. Following a comprehensive portfolio assessment, Merck,
through a subsidiary, has decided that it will no longer pursue development
of vintafolide... 阅读全帖 |
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z*****8
发帖数: 81 | 45 审稿机会，Journal of Food Processing & Technology
title： Physico-chemical characteristics, analytics and metabolism of folate
in plants
有兴趣的给我姓名，单位，职位，email，我推荐给编辑（当然不能保证一定转给你）
。 |
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w****i
发帖数: 233 | 46 您好，能把审稿机会转给我么，已经给你站内发信了，谢谢！
folate |
|
d******8
发帖数: 3017 | 47 Almonds
Nutritional value per 100 g (3.5 oz)
Energy 2,408 kJ (576 kcal)
Carbohydrates 21.69 g
- Starch 0.74 g
- Sugars 3.89 g
- Lactose 0.00 g
- Dietary fiber 12.2 g
Fat 49.42 g
- saturated 3.731 g
- monounsaturated 30.889 g
- polyunsaturated 12.070 g
Protein 21.22 g
- Tryptophan 0.214 g
- Threonine 0.598 g
- Isoleucine 0.702 g
- Leucine 1.488 g
- Lysine 0.580 g
- Methionine 0.151 g
- Cystine 0.189 g
- Phenylalanine 1.120 g
- Tyrosine 0.452 g
- Valine 0.817 g
- Arginine 2.446 g
- Histidine 0.... 阅读全帖 |
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k****a
发帖数: 4944 | 48 #1 Leafy greens
Leafy greens are high in nutrients like folate and vitamins A and C that
can lower your risk of cancer. Just one cup of dark, leafy greens a day
could also prevent diabetes and high blood pressure.
#2 Nuts
Many nutritionists recommend nuts like almonds, cashews and walnuts because
they're high in natural fiber. Fiber slows your digestive process, keeping
hunger and unhealthy mid-afternoon snacks at bay. Goodbye vending machine
runs!
#3 Onions
Studies show that consuming onions on |
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s******g
发帖数: 755 | 49 Eating a salad every day with your favorite salad dressing is an easy way to
add valuable nutrients to your diet – nutrients that promote good health
and may ward off disease. Visit www.saladaday.org to find creative salad
recipes and learn the health benefits of eating salads with your favorite
dressing. You will find salad recipes with chicken, salad recipes with pasta
and vegetable salads, all with great salad dressing recommendations.
Salad eaters tend to have higher intakes of key nutrients... 阅读全帖 |
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