Biology版 - MCBJC paper for discussion-042803 |
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r**r
发帖数: 171 | 1
A Role for Ran-GTP and Crm1 in Blocking Re-Replication.
Yamaguchi R, Newport J.
Department of Biology, University of California, San Diego, 9500 Gilman Drive,
92093, La Jolla, CA, USA
All eukaryotic cells have regulatory mechanisms that limit genomic replication
to a single round each cell cycle. These systems function by blocking
formation of prereplication complexes. The regulatory mechanisms in the yeast
S. cerevisiae have been identified, but these do not appear to be conserved in
metazoan | M****e
发帖数: 70 | 2 this is a good paper that tries to dissect the regulatory
mechanism of strict control on DNA replication during cell
cycle. to ensure only one round of DNA replication at each
S phase, yeast S. cerevisiae exploits cdk2 kinase to regulate
functionally reduntant pathways: degradation of Cdc6, export
of MCM from the nucleus, and phosphorylation of ORC. however,
the mechanism in metazoan is unclear while the cellular
targets of cdk2 have not been completely understood yet.
the author (only one besid |
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| ● microarray表达没有差异会是我的问题么？ | ● Re: MCBJC, cell division (discussion?) | | ● 有些困惑，想问一下各位牛人做试验都重复几次 | ● Re: MCBJC, cell division, Jan 20 2003, by Assasin | | ● 关于Error bar的问题 | ● MCBJC, cell division, discussion | | ● 请教个统计方面的问题 | ● Re: MCBJC, cell division (more discussion, 我又来乐) | | ● 从纯化到星辰---CSH蛋白质纯化课侧记（七） | ● paper help/ call for MCBJC discussion | | ● Paper help! | ● Re: MCBJC-call for discussion | | ● yeast 种类 | ● Re: MCBJC, cellular neurobiology, Mar. 10, 2 | | ● 请问R大牛或者懂RNA-SEQ分析的牛人，DESeq里面怎么对partially replicates的sample进行分析啊？谢！ | ● Call for MCBJC pathway, Mar. 31 |
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