i*********0
发帖数: 915 | 1 一个和centrosome想关的gene, knockout以后,发现neuroprogenitor的division mode
有变化,主要是
symetric/asymetric的比例有点变化,然后脑子和身体成比例的小(相比较control).
我不知道这个发现在neuroscience领域能发表什么样的paper. |
a****d
发帖数: 1919 | 2 depends on how fay you can go with the mechanism to further address the
phenotypes, I would say somewhere from J of Neuroscience, Gene&development
to neuron. |
n********k
发帖数: 2818 | 3 centrosomin or what? Is it a known gene involved in Microcephaly...it could
be very interesting and go as high as you could imagine, provided you have
a nice/comprehensive story with very solid data with/without a bull boss...
in a word, it largely depends on ur story and how u sell it...
mode
【在 i*********0 的大作中提到】
: 一个和centrosome想关的gene, knockout以后,发现neuroprogenitor的division mode
: 有变化,主要是
: symetric/asymetric的比例有点变化,然后脑子和身体成比例的小(相比较control).
: 我不知道这个发现在neuroscience领域能发表什么样的paper.
|
n***w
发帖数: 2405 | 4 Nde1?
could
have
【在 n********k 的大作中提到】
: centrosomin or what? Is it a known gene involved in Microcephaly...it could
: be very interesting and go as high as you could imagine, provided you have
: a nice/comprehensive story with very solid data with/without a bull boss...
: in a word, it largely depends on ur story and how u sell it...
:
: mode
|
n***w
发帖数: 2405 | |
c*********r
发帖数: 1312 | 6 和PCP（Planar Cell Polarity）相关吗？这个我很感兴趣！^_^
mode
【在 i*********0 的大作中提到】
: 一个和centrosome想关的gene, knockout以后,发现neuroprogenitor的division mode
: 有变化,主要是
: symetric/asymetric的比例有点变化,然后脑子和身体成比例的小(相比较control).
: 我不知道这个发现在neuroscience领域能发表什么样的paper.
|
n***w
发帖数: 2405 | 7 我原来读过04年neuron上一篇文章：Mitotic spindle regulation by Nde1 controls
cerebral cortical size. |
l***m
发帖数: 26 | 8 读读吧：09 nature :Asymmetric centrosome inheritance maintains neural
progenitors in the neocortex.
读完就该知道了。 |
j*****d
发帖数: 787 | 9 This article did no talk about the ratio of brain size and body size. His
question is very interesting.
Its signinificance (Shi's paper) is from the CLASSIC topic of cell division
and cell differentiation. The problem is still here: what kinds of
positional signal provide the assymytric informaiton of centrosome?
【在 l***m 的大作中提到】
: 读读吧：09 nature :Asymmetric centrosome inheritance maintains neural
: progenitors in the neocortex.
: 读完就该知道了。
|
