R******d
发帖数: 1436 | 1 很多文献都说组蛋白修饰和基因表达水平有关。是不是有两种可能的机理：
1，修饰后的组蛋白直接招募转录因子，或者驱赶转录因子，启动或者中止转录。
2，修饰后的组蛋白和nucleosome/chromatin remodeling蛋白复合体结合，导致染色体
结构开放
或关闭。从而利于或者抑制转录。
请问1和2哪个正确？可否给点支持文献。
非本专业，请不吝赐教，包子酬谢。 |
n******u
发帖数: 418 | 2 对于acetylation，是第二个情况
其余的modification不了解 |
A******y
发帖数: 2041 | 3 Simplified version for acetylation is number 2. However, acetylated histone
also recruit activation factors and displace silencing factors. Usually
for all transcription number 1 combining with number 2 is correct, don't
forget the HAT/HDAC has to be regulated to know which genes to turn on and
off. |
R******d
发帖数: 1436 | 4 很有意思，多讲两句吧。包子发了。
histone
Usually
and
【在 A******y 的大作中提到】
: Simplified version for acetylation is number 2. However, acetylated histone
: also recruit activation factors and displace silencing factors. Usually
: for all transcription number 1 combining with number 2 is correct, don't
: forget the HAT/HDAC has to be regulated to know which genes to turn on and
: off.
|
