w**e
发帖数: 2358 | 1 我不是很理解为什么有长寿命浆细胞？不是有memory B细胞可以一直分化么？什么影响
他们变成短寿命和长寿命的浆细胞 （比如说GC里的）？？
谢谢～～ | s****9
发帖数: 932 | 2 Generally, short-live plasma cells are less affinity-matured and do not go
through GC. They are quick sources for antibody neutralization.
Long-Live plasma cells are generated from GC and residue in the BM. They
provide the antibody reservoir in your blood for pathogen neutralization.
Memory B cells take a few days to further differentiation into plasma cells
and cannot replace long live plasma cells.
It is a big questions in the field that which factors determine the
differentiation of short-live and long-live plasma cells. I think the best
evidence is that high affinity B cells tends to become short live plasma
cells but low affinity ones enter GC for further affinity maturation.
【在 w**e 的大作中提到】
: 我不是很理解为什么有长寿命浆细胞？不是有memory B细胞可以一直分化么？什么影响
: 他们变成短寿命和长寿命的浆细胞 （比如说GC里的）？？
: 谢谢～～
| w**e
发帖数: 2358 | 3 谢谢这么好的解释， 有没有什么方面的papers说什么影响他们的寿命？是不是和这些
细胞所处在的地方有关系？ 比如说活得长的在BM里面,短的在LN? 那样的话是不是换换
环境他们就变了？XD
cells
best
【在 s****9 的大作中提到】
: Generally, short-live plasma cells are less affinity-matured and do not go
: through GC. They are quick sources for antibody neutralization.
: Long-Live plasma cells are generated from GC and residue in the BM. They
: provide the antibody reservoir in your blood for pathogen neutralization.
: Memory B cells take a few days to further differentiation into plasma cells
: and cannot replace long live plasma cells.
: It is a big questions in the field that which factors determine the
: differentiation of short-live and long-live plasma cells. I think the best
: evidence is that high affinity B cells tends to become short live plasma
: cells but low affinity ones enter GC for further affinity maturation.
| w**e
发帖数: 2358 | |
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