m****s
发帖数: 18160 | 1 【 以下文字转载自 Biology 讨论区 】
发信人: BachCello (cello), 信区: Biology
标 题: Postdoc positions in Weill Cornell medical college
发信站: BBS 未名空间站 (Mon Jul 29 16:32:52 2013, 美东)
Description
POSTDOCTORAL POSITION – Hematopoietic Stem Cell Biology
Weill Cornell Medical College, Cornell University, New York, NY
A postdoctoral position is available to investigate mechanisms controlling
hematopoietic stem cell (HSC) quiescence and how disruption of these
mechanisms contributes to the pathogenesis of hematopoietic malignancies.
The laboratory utilizes primary human cells and genetic mouse models to
study the regulation of HSC quiescence during physiologic stresses such as
myelosuppressive chemotherapy, infection and blood loss/cytopenias. A
particular focus is defining the contribution of TGFβ to the bone marrow
niche support of HSC function. The laboratory uses a wide variety of
technologies (advanced microscopy, multidimensional flow cytometry, “
NextGen” RNAseq, ChIPseq) and highly specialized assays of hematopoiesis to
pursue these goals.
Postdoctoral applicants should have demonstrated expertise using mouse model
systems with preference given to those applicants having experience with
hematopoietic studies. Applicants should be have experience with flow
cytometry and immunohistochemistry/immunofluorescence techniques and
technologies. A strong background in molecular biology is preferred and
applicants should also be familiar with massively parallel (NextGen)
sequencing technologies.
The laboratory is located on the main campus of Weill Medical College of
Cornell University at York Avenue and 69th street in New York City, easily
accessible to all parts of the city.
Interested applicants should submit an electronic copy of CV, the names and
contact info for three references and a cover letter describing past
research experience, research interests and career goals to: Dr. Joseph
Scandura, J*****[email protected].
Requirements:
Strong English speaking and writing skills and a track record of peer-
reviewed publications.
PhD in molecular, cellular biology preferred.
Contact:
Dr. Joseph Scandura, M.D., Ph.D.
1300 York Avenue, Box 113
New York, NY 10065
J*****[email protected]
Description
POSTDOCTORAL POSITION – Personalizing Epigenetic Therapy for Myeloid
Malignancies
Weill Cornell Medical College, Cornell University, New York, NY
A postdoctoral position is available to help develop effective and well-
tolerated epigenetic therapies for myeloid malignancies such as acute
myelogenous leukemia (AML), myelodysplastic syndrome (MDS) and
myeloproliferative neoplasms (MPNs). A particular focus of the laboratory is
the use of DNA methylation biomarkers to report in vivo pharmacodynamic
responses to DNA hypomethylationg agents (DHAs). This work builds upon
research identifying recurrent AML-specific abnormalities of DNA methylation
specific to AML leukemic stem and progenitor cells (LSPCs). Having
identified pharmacodynamic biomarkers of DHA activity in AML LSPCs, we have
now developed a platform for rapid pharmacodynamic evaluation and clonal
tracking of DNA hypomethylation biomarkers by deep bisulfite sequencing
using a rapid “table-top” sequencer. This approach promises to permit
short-term HMA response markers to optimize, and perhaps individualize, HMA
treatment strategies thereby maximizing anti-leukemic activity while
minimizing toxicity. Predicting future clinical response using current
pharmacodynamic measures promises to fundamentally change the way that we
treat patients with DHAs by allowing us to know which patients should
proceed with therapy despite the lack of clinical response and to rapidly
identify those who would be better served by a change in therapy. This
approach will speed development of new HMA regimens and avoid unnecessary
treatment of patients who will never respond to HMAs. This work is currently
linked to several clinical trials involving DHAs for AML. The laboratory
uses a wide variety of technologies (multidimensional flow cytometry, “
NextGen” RNAseq, ChIPseq) and highly specialized assays of DNA methylation
and analysis of other epigenetic marks in purified primary cells to pursue
these goals.
Postdoctoral applicants should have demonstrated expertise in molecular and
cell biology with preference given to those applicants having experience
with normal or malignant and hematopoiesis. A strong background in molecular
biology is preferred and applicants should also be familiar with massively
parallel (NextGen) sequencing technologies.
The laboratory is located on the main campus of Weill Medical College of
Cornell University at York Avenue and 69th street in New York City, easily
accessible to all parts of the city.
Interested applicants should submit an electronic copy of CV, the names and
contact info for three references and a cover letter describing past
research experience, research interests and career goals to: Dr. Joseph
Scandura, J*****[email protected].
Requirements:
Strong English speaking and writing skills and a track record of peer-
reviewed publications.
PhD in molecular, cellular biology preferred.
Contact:
Dr. Joseph Scandura, M.D., Ph.D.
1300 York Avenue, Box 113
New York, NY 10065
J*****[email protected] |
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