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全部话题 - 话题: metabolism
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T****x
发帖数: 950
1
来自主题: Tennis版 - 太惊人了,莎娃作弊
禁的呀。。而且和莎娃这个非常相似,最初都是治疗心脏的,但是可以提高代谢,促进
血流的。孙杨吃的是5.4,莎娃吃的是5.3,都是一类
S4 The following hormone and metabolic modulators are prohibited
Metabolic modulators:
5.2 Insulins and insulin-mimetics;
5.3 Meldonium;
5.4 Trimetazidine
兴奋剂这事情,说白了很多运动员都在打擦边球,还不在list,但是能提高或者可能提
高成绩训练什么的我就吃吃。但是什么东西上list什么不上,话语权还是在美国/西欧
。那些田径项目游泳项目我觉得就没一个干净的,不管是美国牙买加还是澳大利亚法国
中国,肯定都吃吧
B******1
发帖数: 9094
2
来自主题: Weightlifting版 - 150 磅了 (慎入)
The problem with a hardgainer, or a naturally skinny person, is his or her high metabolic rate, which burns more calories than a normal person. However, remedy is readily available by modifying their bodybuilding training and nutrition program to suit his/her unique metabolic demands. The key is to minimize unwanted waste of energy burns and maximize energy intakes.
For example, for a 150 lb hardgainer, he or she can eat up to 150x24=3600 calories per day and increase the carbohydrate percenta
s*****W
发帖数: 117
3
来自主题: Weightlifting版 - 150 磅了 (慎入)
这位Beida101老兄理论很深厚嘛,那你说说一周一磅的bulking时快时慢?就是重量,别说什么肌肉脂肪比例。

high metabolic rate, which burns more calories than a normal person.
However, remedy is readily available by modifying their bodybuilding
training and nutrition program to suit his/her unique metabolic demands.
The key is to minimize unwanted waste of energy burns and maximize energy
intakes.
calories per day and increase the carbohydrate percentage to 50%. You can
take in all these calories in as many meals as you stomach can handle. B
r*s
发帖数: 2555
4
Two Dutch scientists — both men, published a paper in the journal Nature
Climate Change, said most office temperature standards were based on a
1960s-era “thermal comfort model” using men’s metabolic rates. (
Specifically, the metabolic rate of a 40-year-old, 154-pound man).
http://www.nytimes.com/2015/08/05/science/blame-a-male-biased-a
l*****o
发帖数: 26631
5
Long-Term Health Risks and Benefits Associated with Spay / Neuter in Dogs
Laura J. Sanborn, M.S.
May 14, 2007
Precis
At some point, most of us with an interest in dogs will have to consider
whether or not to spay / neuter our pet. Tradition holds that the benefits
of doing so at an early age outweigh the risks. Often, tradition holds sway
in the decision-making process even after countervailing evidence has
accumulated.
Ms Sanborn has reviewed the veterinary medical literature in an exhaustive
a... 阅读全帖
F******7
发帖数: 4765
6
来自主题: Prose版 - 板斧,我来改正错误了

http://www.popsci.com/science/article/2013-02/why-coffee-good-y
7 Reasons Why Coffee Is Good For You
By Kris Gunnars/ Authority Nutrition Posted 02.21.2013 at 11:00 am 25
Comments
Coffee beans Dreamstime
Coffee isn’t just warm and energizing, it may also be extremely good for
you.
In recent years and decades, scientists have studied the effects of coffee
on various aspects of health and their results have been nothing short of
amazing.
Here are 7 reasons why coffee may actually be one of the he... 阅读全帖
F******7
发帖数: 4765
7
来自主题: Prose版 - 板斧,我来改正错误了

http://www.popsci.com/science/article/2013-02/why-coffee-good-y
7 Reasons Why Coffee Is Good For You
By Kris Gunnars/ Authority Nutrition Posted 02.21.2013 at 11:00 am 25
Comments
Coffee beans Dreamstime
Coffee isn’t just warm and energizing, it may also be extremely good for
you.
In recent years and decades, scientists have studied the effects of coffee
on various aspects of health and their results have been nothing short of
amazing.
Here are 7 reasons why coffee may actually be one of the he... 阅读全帖
s****a
发帖数: 1039
8
来自主题: FDU版 - Niubility
http://www.sciencemag.org/current.dtl
Regulation of Cellular Metabolism by Protein Lysine Acetylation
Shimin Zhao, Wei Xu, Wenqing Jiang, Wei Yu, Yan Lin, Tengfei Zhang, Jun Yao
, Li Zhou, Yaxue Zeng, Hong Li, Yixue Li, Jiong Shi, Wenlin An, Susan M.
Hancock, Fuchu He, Lunxiu Qin, Jason Chin, Pengyuan Yang, Xian Chen, Qunying
Lei, Yue Xiong, and Kun-Liang Guan
Science 19 February 2010: 1000-1004.
Regulation of enzymes by acetylation controls metabolic function in human
liver cells.
Acetylation o
t****p
发帖数: 1504
9
在过去的4000年里,生活在青藏高原上的牧民依赖牦牛而不是普通的牛来驮载货物。虽
然牛和牦牛有紧密的关系——仅仅在490万年前,这两者才开始出现分离,同一时间,
人类和黑猩猩也“分道扬镳”,但是驯养的牦牛却能够更好地适应这一地区的极端海拔
高度——牦牛能够生活在超过4500米的高海拔地区。
最近一项新研究中,研究人员揭示了牦牛这项生存能力背后的遗传学因素。研究人员通
过对已驯化的雌性牦牛的基因组研究,发现牦牛的几个基因让它能够更好地适应高海拔
地区的生活。相关研究成果在线发表于《自然遗传学》杂志。
研究显示,有三个基因能够帮助这种动物调节其身体对于高海拔地区氧气不足或缺氧情
况的反应,另外五个基因则能帮助它最优化利用其从食物中获得的能量——高原上,食
物也十分缺乏。
研究人员还表示,通过研究在高海拔地区生活所需要的基因,科学家或许能够找到办法
以更好地治疗和预防高空病以及与缺氧有关的并发症,例如高海拔脑水肿和高海拔肺水
肿等,这些疾病对人类有致命影响。(生物谷Bioon.com)
doi:10.1038/ng.2343
PMC:
PMID:
The yak genome and ada... 阅读全帖
t****p
发帖数: 1504
10
在过去的4000年里,生活在青藏高原上的牧民依赖牦牛而不是普通的牛来驮载货物。虽
然牛和牦牛有紧密的关系——仅仅在490万年前,这两者才开始出现分离,同一时间,
人类和黑猩猩也“分道扬镳”,但是驯养的牦牛却能够更好地适应这一地区的极端海拔
高度——牦牛能够生活在超过4500米的高海拔地区。
最近一项新研究中,研究人员揭示了牦牛这项生存能力背后的遗传学因素。研究人员通
过对已驯化的雌性牦牛的基因组研究,发现牦牛的几个基因让它能够更好地适应高海拔
地区的生活。相关研究成果在线发表于《自然遗传学》杂志。
研究显示,有三个基因能够帮助这种动物调节其身体对于高海拔地区氧气不足或缺氧情
况的反应,另外五个基因则能帮助它最优化利用其从食物中获得的能量——高原上,食
物也十分缺乏。
研究人员还表示,通过研究在高海拔地区生活所需要的基因,科学家或许能够找到办法
以更好地治疗和预防高空病以及与缺氧有关的并发症,例如高海拔脑水肿和高海拔肺水
肿等,这些疾病对人类有致命影响。(生物谷Bioon.com)
doi:10.1038/ng.2343
PMC:
PMID:
The yak genome and ada... 阅读全帖
j****u
发帖数: 1413
11
2015年8月22日,波士顿科大校友会将举办首次医药行业的校友沙龙聚会。我们邀请到
了波士顿医药界三位资深校友陈寅(808),金晓玮(843) 和李劲波(863)为我们做嘉宾演
讲,纵论中美医药行业发展的机遇和挑战并分享作为科大校友在医药行业发展的心得体
会。欢迎中国科大校友参加,一同欢聚在查尔斯河河畔!
通知网址:http://ustcbaa.com/events/%E6%B3%A2%E5%A3%AB%E9%A1%BF%E4%B8%AD%E5%9B%BD%E7%A7%91%E5%A4%A7%E6%A0%A1%E5%8F%8B%E6%91%86%E4%B8%8B%E9%BE%99%E9%97%A8%E9%98%B5%E5%A4%A7%E8%AF%9D%E5%8C%BB%E8%8D%AF%E5%88%9B%E6%96%B0%E9%A2%86%E5%9F%9F/
时间: 2015年8月22日14:00-16:00
地点:220 Longwood Ave, Boston, MA。 教室 Goldenson 122, Harvard Medical
School(周围停车较不便, 可乘坐绿线... 阅读全帖
x********u
发帖数: 430
12
来自主题: Biology版 - 求教 system biology
I am just gona start my PhD project in metabolic engineering. One area I
found extremely fascinating is about mathematical modelling of metabolic
network for prediction of knockout or overexpression targets for improving
the production of certain commercially important pharmaceuticals. But
recently I felt somewhat frustrating when I read some paper from Palsson's (
UCSD) group. I am not scared by the genome-scaled constraints-based model
but the software they are using. I am kind of an idiot in
f*********e
发帖数: 199
13
来自主题: Biology版 - 发几个生物相关的faculty opening
我当时贴了附件的啊,不知道为什么没显示出。现在贴不上了,干脆直接粘贴内容好了
METABOLIC ENGINEERING and
SYNTHETIC BIOLOGY
Competition # 7789 – 2 positions
All facets of metabolic engineering and
synthetic biology, from technology
development and computational
approaches to innovative applications,
will be considered. Applicants with an
interest in bioenergy and biorefining are
particularly encouraged to apply.
CHEMICAL, MOLECULAR AND SYSTEMS
BIOLOGY, and BIOENGINEERING
Competition # 7790 – 2 positions
Approaches using molecular genet
s**********e
发帖数: 2888
14
我博士导师需要马上招一个博后,非常非常nice的一个美国人。广告全文在下面,有兴
趣的可以直接联系他,位置是在UW-Madison,谢谢。
这个工作是部分延续我们实验室以前做的一部分化学的工作,这个位置是AICR的
funding资助做后面的机理工作,所以相关的文章很多还没有发表出来。有兴趣的可以
直接联系他,或者想知道实验室情况的也可以问我,谢谢。
我已经毕业了,我的博士老板是我这么多年遇到的最nice和对我事业帮助最大的人,所
以帮他把广告贴在这里。
Department of Food Science Research Associate opportunity
Post-doctoral Research Associate. Project involves evaluation of
biological activities related to anti-cancer effects of naturally occurring
organosulfur components, including metabolic fate and cell signaling ... 阅读全帖
C******r
发帖数: 790
15
一共3天分了6个section,每个section三四个speakers,包括cancer, metabolism,
neuroscience, immunology, plant, 和stem cell。
Keynote: David Baltimore
Cancer: Tony Hunter, Bob Weinberg, Craig Thompson, Brian Druker;
Metabolism: Ron Evens, Bruce Spiegelman, Tamas Horvath, Jeff Gordon, Joe
Goldstein;
Neuroscience: Terry Sejnowski, Susan K. McConnell, Larry Swanson, Bob Wurtz,
Susumu Tonegawa;
Immonology & Virology: Inder Verma, Ruslan Medzhitov, Fiona Powrie, Dan
Littman, Didier Trono;
Plant: Joanne Chory, Elliot Meyer... 阅读全帖
c******n
发帖数: 5697
16
Arsenate也就是AsO4(3−)是phosphate analogue,也就是说对蛋白酶来讲,AsO4(3−)和PO4(3-)无区别,所以细菌的enzyme完全可以把它错当PO4(3-)使用,加入DNA和protein里,这个没有多大意义,你们还争论用不用分析化学鉴定,没意思
最主要的是As妨碍普通细胞的呼吸oxidative phosphorylation,普通细胞没法在As下生存,不可能繁殖
但是这种几年前就被发现了的细胞有酶可以中和As,还可以靠As呼吸, 所以可以靠As生长,所以在用As替换P的环境下繁殖,就丝毫不足为奇了
所以更有意义的发现不是As替代P, 而是细菌可以在As里繁殖。这是个老消息了,可怜NASA不要脸,又玩花样骗钱
早就说过了,NASA是个很可怜的机构,在资本主义社会中没有任何存在的意义,所以要向好莱坞学习,不停搞出新闻来,才可以吸引缴税人民的注意力,搞研究经费
http://www.microbemagazine.org/index.php/02-2010-home/1358-microbial-arsenic-metaboli... 阅读全帖
j********8
发帖数: 21
17
讲的就是基因组印记?
要是这样岂不是将灌水发挥到了极至?
Paternally Induced Transgenerational
Environmental Reprogramming of
Metabolic Gene Expression inMammals
Epigenetic information can be inherited through the
mammalian germline and represents a plausible
transgenerational carrier of environmental information.
To test whether transgenerational inheritance
of environmental information occurs in mammals, we
carried out an expression profiling screen for genes
in mice that responded to paternal diet. Offspring
of males fed... 阅读全帖
D*a
发帖数: 6830
18
我猜是另一个人。。。
总之他是搞metabolism的,因为他通篇都是metabolism的问题。。。
当然我承认这个breeding strategy,作为问题还是挺有意思的。。。 但是作为
comment也太不着调了。。。
q*******1
发帖数: 2
19
please see below detailed JD:
Executive Director of Discovery Biology
Location: Beijing
Key activities: Oversee biology-related research and drug discovery
activities to execute departmental strategies and meet deliverables.
Successful candidate is also responsible for biology resource allocation,
recruitment and the professional development of biology staff.
Requirements:
• Ph.D. in biology, cell biology, immunology, biochemistry,
virology, pharmacology or a related field with an ou... 阅读全帖
x********u
发帖数: 430
20
来自主题: Biology版 - 大家讨论一下synthetic biology吧
I am now trying to switch my PhD project to SynBio area. My current work
focus on creating the best phenotype or genetic background to maximize
carbons flux towards an important intermediate metabolites and ulitmately we
are going to overproduce some natural products. Currently, the volumetric
production of one of our major products has reached 2 g/l.
Although traditional metabolic engineering or metabolic network modeling
holds great promise to engineer better industrially-revelant phenotype, g... 阅读全帖
z*h
发帖数: 773
21
来自主题: Biology版 - 大家讨论一下synthetic biology吧
The use of metabolic model for simulation of complicated biological system
is a day dream based on available knowledge. The father of metabolic
engineering -- JE Bailey -- pointed it out in 1998.
Bailey, J. E. (1998) Mathematical modeling and analysis in biochemical
engineering: past accomplishments and future opportunities, Biotechnol. Prog
. 14, 8-20.
Who are really hearing his suggestions? In vivo synthetic biology for
biofuels production will be a dead end surely because of poor efficiencies... 阅读全帖
x********u
发帖数: 430
22
来自主题: Biology版 - 大家讨论一下synthetic biology吧
I am now trying to switch my PhD project to SynBio area. My current work
focus on creating the best phenotype or genetic background to maximize
carbons flux towards an important intermediate metabolites and ulitmately we
are going to overproduce some natural products. Currently, the volumetric
production of one of our major products has reached 2 g/l.
Although traditional metabolic engineering or metabolic network modeling
holds great promise to engineer better industrially-revelant phenotype, g... 阅读全帖
z*h
发帖数: 773
23
来自主题: Biology版 - 大家讨论一下synthetic biology吧
The use of metabolic model for simulation of complicated biological system
is a day dream based on available knowledge. The father of metabolic
engineering -- JE Bailey -- pointed it out in 1998.
Bailey, J. E. (1998) Mathematical modeling and analysis in biochemical
engineering: past accomplishments and future opportunities, Biotechnol. Prog
. 14, 8-20.
Who are really hearing his suggestions? In vivo synthetic biology for
biofuels production will be a dead end surely because of poor efficiencies... 阅读全帖
h**********r
发帖数: 671
24
来自主题: Biology版 - 大家讨论一下synthetic biology吧
Thanks!
我现在主要做代谢工程(不要脸的说,阿猫阿狗都做metabolic engineering,
synthetic biology),这些circuit够fancy,但是我在想一个能够够好的调控metabolic
engineering里的基因表达的,要够fancy,有模型,有产量。
我总不能说,嘿,我的产物(酶)是oscillation的吧。
感觉吧,synthetic biology有点问题,又说不出来。
h**********r
发帖数: 671
25
来自主题: Biology版 - 大家讨论一下synthetic biology吧
Thanks!
我现在主要做代谢工程(不要脸的说,阿猫阿狗都做metabolic engineering,
synthetic biology),这些circuit够fancy,但是我在想一个能够够好的调控metabolic
engineering里的基因表达的,要够fancy,有模型,有产量。
我总不能说,嘿,我的产物(酶)是oscillation的吧。
感觉吧,synthetic biology有点问题,又说不出来。
h*******o
发帖数: 4884
26
There are many ways to assess mitochondrial/bioenergetic capacity.
Of course the most direct and wildly accepted is to measure mitochondrial
respiration through a Clark-type electrode.
Alternatively, cellular oxygen consumption can be measured through an oxygen
sensitive probe (used to be called A65N, but now commercialized as
MitoXpress via Luxcell). This method only requires a fluorescent plate
reader in addtion to mitoXpress, which should be available to most
biomedical labs/departments.
My p... 阅读全帖
x*y
发帖数: 32
27
来自主题: Biology版 - 招聘Postdoc & Research Scientists
Postdoctoral Fellowships
Postdoctoral positions are available to explore metabolic diversity
among bacteria that degrade natural and synthetic organic compounds. The
emphasis is on discovery of novel enzymes and catabolic pathways using
microbial physiology, genomics, and molecular biology. A second position
will emphasize biodegradation kinetics and mechanisms in natural soils
and sediments. The laboratory is well equipped with analytical
instruments and all the facilities needed for cell culti... 阅读全帖
s*******s
发帖数: 623
28
Job ID: GF2011A001
Posting Title: Research Scientist/Research Associate/Bacterial Geneticist
Brief Introduction of Gate Fuels Inc.: “Imagination, Innovation,
Implementation --- Enabled Technologies for a Green Clean World”
Gate Fuels Inc. is a research start-up firm based in Blacksburg, VA, with
the goal of developing microbial and cell-free platform technologies that
enable low-cost production of biochemicals and biofuels. The first platform
is based on industrially-safe Bacillus subtilis. Thi... 阅读全帖
N*S
发帖数: 783
29
search了一下,看到了不少老同学的名字。。。徐涛估计搞行政去了。。。
07年一片neuron,一片cell metabolism,
06年一片cell metabolism,
a********k
发帖数: 2273
30
花了一个小时,深深的鄙视一下自己的无聊行径!!
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branches in lamellipodia. Cell. 2008 Sep
5;134(5):828-42. PubMed PMID: 18775315; PubMed Central PMCID: PMC2570342.
Cai L, Makhov AM, Bear JE. F-actin... 阅读全帖
y******8
发帖数: 1764
31
来自主题: Biology版 - 请教回国问题,谢谢
Metabolism很复杂啊,metabolites就有上万,微量以上的就有两三千。但是现在能拿
来做临床诊断的才几十个,在模式生物里能用的才十几个。这个要想用老鼠来做,特别
是要做到genetics这个level,metabolism这种日节律很强的phenotype在老鼠上作超烧
钱是一定的。
或者,就直接screen病例,这样不用知道全貌,找到一个新的metabolite,或者一个新
的基因控制已知的metabolite,就算paper发得不高,也是很有用的啊。
p*****m
发帖数: 7030
32
来自主题: Biology版 - adipogenesis还有的做么?
我还是有兴趣的 我本来是想做neuro+metabolism,最近弄着弄着觉得metabolism
itself也有很多有趣的东西没做清楚。。(也可能是我看paper没看清楚,所以要来问
问内行)

the
p*****m
发帖数: 7030
33
来自主题: Biology版 - adipogenesis还有的做么?
嗯 挺多neuro+metabolism,不过我是觉得做得不够好了,尤其是老鼠里。如果你比比我
们对peripheral metabolism (in adipose, liver, muscle, pancreas, etc)的理解和
对brain的理解 能差个数量级吧感觉。
呵呵 还真有人interview问我这个问题。。其实我从来就没想过继续做的说。。所以也
就压根没和他讨论过。。。觉得原来的话题太小众了 不好玩。。

why
something?
it
,
are still young:)))
t*d
发帖数: 1290
34
来自主题: Biology版 - Re: 时间是绝对的吗? (转载)
【 以下文字转载自 History 讨论区 】
发信人: sgld (sgld), 信区: History
标 题: Re: 时间是绝对的吗?
发信站: BBS 未名空间站 (Sat Sep 3 17:51:42 2011, 美东)
转一篇文章。
Ten Things Everyone Should Know About Time
by Sean
“Time” is the most used noun in the English language, yet it remains a
mystery. We’ve just completed an amazingly intense and rewarding
multidisciplinary conference on the nature of time, and my brain is swimming
with ideas and new questions. Rather than trying a summary (the talks will
be online soon), here’s my stab at ... 阅读全帖
y**********n
发帖数: 478
35
Wide range of cellular interaction networks analysis
Metabolic pathways, gene regulation and cell cycles analysis based on
Kinetic biochemical models
Flux balance analysis of genome-scale metabolic networks
the concept of Robustness in biological system
comparative genomics based on numerous genome projects
O******e
发帖数: 4845
36
Severe Congenital Disorder Successfully Treated in a Mouse Model for the
First Time
http://www.sciencedaily.com/releases/2011/12/111222103044.htm
ScienceDaily (Dec. 22, 2011) Using a mouse model, Heidelberg University Ho
spital researchers have for the first time successfully treated a severe con
genital disorder in which sugar metabolism is disturbed. The team headed by
Prof. Christian Korner, group leader at the Center for Child and Adolescent
Medicine, demonstrated that if female mice are giv... 阅读全帖
l**********1
发帖数: 5204
37
来自主题: Biology版 - 造假哥Shigeaki Kato被揪出来了
这下那个韩国BSO女 Mi-Sun Kim 的 博士学位都可能被取消吧
Article No.17
EMBO J. 2004 Apr 7;23(7):1598-608.
Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching.
Murayama A, Kim MS, et al and Kato S.
httq://katolab-imagefraud.blogspot.com/2012/01/transrepression-by-liganded-nuclear.html
如果以上这篇收入了 Mi-Sun Kim 的 博士学位论文的话 2012 EMBO J 公布撤稿的话
CV citation:
March, 2004, Doctor of Philosophy, Agricultural & Life Sciences, University
of Tokyo, Tokyo, Japan
Advisor: Dr. Shigeaki Kat... 阅读全帖
v******l
发帖数: 235
38
来自主题: Biology版 - Paper help
Would someone please help me download this paper? I can't find in our
library. Thanks a lot! My e-mail: j********[email protected]
J Endocrinol Invest. 2005 Apr;28(4):333-9.
PMID: 15966506 [PubMed - indexed for MEDLINE]
Aminotransferase and gamma-glutamyltranspeptidase levels in obesity are
associated with insulin resistance and the metabolic syndrome.
Marchesini G, Avagnina S, Barantani EG, Ciccarone AM, Corica F, Dall'Aglio E
, Dalle Grave R, Morpurgo PS, Tomasi F, Vitacolonna E.
Source
Metabolic Un... 阅读全帖
z********8
发帖数: 818
39

FACS analyze adipocyte progenitor and do some functional assays
这种实验没有必要先做的。可能是放到你整个实验的最后那一步。
先是chow diet,检测体重,饮食量,ITT, ogtt or igtt, 血液指标,脂肪含量/体重
,有变化,做个脂肪组织和肝组织的切片看看。有变化再做个能量代谢。
如果chow diet,你的这个ko 小鼠都有变化,那就神了,说明这个基因很强啊。
不管有没有变化,用个High fat diet试试,也许能看出更明显的效果,重复同样的实
验。
如果想做的fancy一点,cross到ob/ob or db/db mice,这个要看你ko mice是什么背景了.
不要用什么STZ之类的。
最后做各种实验,分析机理。
B6j是做metabolism公认的,6n背景,有的reviewer会不认可,当然了B6j是非常容易诱
导成metabolism dysfunction的小鼠了。
d****d
发帖数: 214
40
来自主题: Biology版 - JCI: 三巨头华山论剑
A conversation with Robert Lefkowitz, Joseph Goldstein, and Michael Brown
Ushma S. Neill and Howard A. Rockman
Published May 1, 2012
Today we shift the format of our Conversations with Giants in Medicine and
allow three of our most charismatic giants (Robert Lefkowitz, Joseph
Goldstein, and Michael Brown) to interview each other (Figure 1). Lefkowitz
(Duke University) is known for his seminal discoveries in understanding G
protein–coupled receptor function. The legendary partnership between Brow... 阅读全帖
n***w
发帖数: 2405
41
前两天,例行搜paper,
找到了如下这篇:Altered mitochondrial function and metabolic inflexibility
associated with loss of caveolin-1
http://www.cell.com/cell-metabolism/abstract/S1550-4131(12)0000
Richard G Anderson是其中的一个senior author,
下面一行字,this paper is dedicated to the memory of our wonderful colleague
Dr. Richard Anderson, who recently passed away.
我是多么的后知后觉,他老人家竟然仙逝了。
从我加入现在这个实验室开始,因为做的东西涉及lipid rafts and caveolae,所以读
了很多他写的review和他们组的paper,他们1992那篇发现caveolin-1的paper仍然是记
忆犹新。
老板还和我说,他曾经和他一起坐过出租车,还介绍了一下业内人士进... 阅读全帖
s**i
发帖数: 4448
42
Current Topics in Medicinal Chemistry; Aug2006, Vol. 6 Issue 15, p1641-1654,
14p
Current Drug Metabolism, Volume 9, Number 6, July 2008 , pp. 498-504(7)
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY Volume: 3 Issue: 2 Pages
please send a full text copy to my gmail at j***************[email protected]
l**********1
发帖数: 5204
43
Conti:
以下的PIs 都能看明白那本1892的PhD thesis
不然 不用混这一行了
Biology/Biochemistry Researchers
Member Affiliation Research Interests
Judy Armitage University of Oxford Bacterial networks and protein
dynamics
Ian Stansfield University of Aberdeen The mechanism of protein
synthesis in eukaryote cells, and in the control of gene expression at the
level of mRNA translation, both using the yeast Saccharomyces as a model
system
David Fell Oxford Brookes University General principl... 阅读全帖
l**********1
发帖数: 5204
44
来自主题: Biology版 - 借人气求祝福
Cong!
Merci Baozis
寄信人: deliver (自动发信系统)
标 题: 本站转帐通知单
发信站: BBS 未名空间站 (Thu Oct 18 13:52:58 2012)
来 源: mitbbs.com
lotkaeuler11,您好:
metabolism 转给您,现金(伪币): 20 .
附加留言:
多谢祝福,文章接受,发2个包子谢谢你!!
metabolism
y**********o
发帖数: 37
45
最近一直在考虑career的问题,估计是年纪大了,想安定了。
个人背景:国内三流医学院毕业,国内生物硕士,加拿大生物硕士,毕业后留实验室做
技术员一年多。
目前考虑一年内办好移民后换份工作。个人没什么太大的追求,只想有份稳定、收入说
得过去的工作。考执照做医生是基本不去想了,不知道还有没有其它的选择。
以前读书的时候一直忙于实验(老板比较push),从未认真考虑过这个问题。
技术方面主要做分子和细胞的实验,目前管理10多个mouse lines,可以做MCAO,brain
injection这样的实验,也可以做切片、染色以及in situ。所做课题和metabolism相关
,GTT,ITT以及分离各种老鼠组织都非常熟练。不知是否有机会去一些公司做
metabolism相关的研究?
另外考虑过读个physician assistant的学位去医院工作,似乎更稳定点。
希望有经验的指点指点,谢谢!
l*****n
发帖数: 24
46
这个Gan boyi人怎么样?一年里面招好多人噢?
Postdoctoral positions are available immediately in a cancer research
laboratory located within The University of Texas MD Anderson Cancer Center
to work in the areas of cancer genetics and cancer signaling. The lab
currently studies metabolic signaling in cancer development, aging and stem
cell maintenance (see our publications, Nature. 2010; 468(7324):701-4;
Cancer Cell. 2010; 18(5):472-84; Cell Cycle. 2009; 8(7):1003-6; PNAS. 2008;
105(49):19384-9). The projects will... 阅读全帖
l*****n
发帖数: 24
47
这个Gan boyi又开始招人了,大家说是不是又是一个Suo Zucai啊,知道的说说,避免上当
受骗!
这个Gan boyi人怎么样?一年里面招好多人噢?
Postdoctoral positions are available immediately in a cancer research
laboratory located within The University of Texas MD Anderson Cancer Center
to work in the areas of cancer genetics and cancer signaling. The lab
currently studies metabolic signaling in cancer development, aging and stem
cell maintenance (see our publications, Nature. 2010; 468(7324):701-4;
Cancer Cell. 2010; 18(5):472-84; Cell Cycle. 2009; 8(7):10... 阅读全帖
j***n
发帖数: 1471
48
来自主题: Biology版 - 求审稿
做的东西比较偏,和以下关键词有关都可以,请站内信,多谢。
Parasitology
Leishmania, Kinetoplastid
Toxoplasma, Apicomplexa
Sphingolipid metabolism
lipid metabolism
protein lipidation
n******t
发帖数: 1281
49
Job ID: GF2013A001
Posting Title: Research Scientist/Research Associate/Bacterial Geneticist/
Fermentation Scientist
Brief Introduction of Gate Fuels Inc.: “Imagination, Innovation,
Implementation --- Enabled Technologies for a Green Clean World”
Gate Fuels Inc. is a research start-up firm based in Blacksburg, VA, with
the goal of developing microbial platform technologies that enable low-cost
production of biochemicals and biofuels. The platform is based on the well-
studied Gram-positive mode... 阅读全帖
j****1
发帖数: 81
50
来自主题: Biology版 - proposal abstract
Here is another abstract, because I have to write two abstracts for my
qualifying exam.
----------------------------------------------------------------------------
-------------
Not only are neural stem cells important in learning and memory, they are
also potential therapeutic approaches for neurodegenerative and other neural
pathological diseases. Adult neurogenesis occurs in the subventricular zone
(SVZ) of the lateral ventricle and subgranular zone (SGZ) in the
hippocampus (Suh et al., 2009... 阅读全帖
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