m***e
发帖数: 482 | 1 DNA repair pathways:
-direct repair
e.g. thymine dimers (DNa photolyase),
DNA adducts caused by alkylating agents (methyltransferases)
-excision repair
base excision repair(BER)
mismatch repair(MMR)
nucleotide excision repair(NER)
-recombinational repair
DNA double-strand break repair: 2 distinct system in eukaryotic cells
1. homologous recombination system
2. non-homologous end-joining (NHEJ) system
en, DNA-dependent proptein kinase is required for normal double-strand break
rejoin |
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