l*****1
发帖数: 8 | 1 Happy new year! I need a paper.
http://www.ncbi.nlm.nih.gov/pubmed?term=21919692
Future Oncol. 2011 Sep;7(9):1045-55.
miRNAs in lung cancer: large roles for small players.
Cherni I, Weiss GJ.
SourceThe Translational Genomics Research Institute, Phoenix, AZ, USA.
Abstract
miRNAs play an important role in the regulation of a wide assortment of
cellular processes by sequestering target mRNAs and inhibiting translation
of the proteins that they encode. Multiple miRNAs can regulate single mRNA
molecules and, alternatively, a single miRNA can act on a number of mRNA
targets. Dysfunctional miRNAs are commonly found in a variety of solid
cancers and are attractive candidates for next-generation therapeutics. This
article highlights miRNA signatures proposed for lung cancer classification
and diagnosis, chemo- and radio-therapy resistance, metastasis and
prediction of treatment outcome and survival.
Please send to:l*******[email protected]. Thanks a lot. |
