b*********y
发帖数: 93 | 1 EPO感受的是hypoxemia还是 hypoxia, 包不包括ischemia? 象贫血，有hypoxia, no
hypoxiemia, 即氧分压是正常的，但氧含量降低，有没有EPO的反应性增高？
谢谢 | N******9
发帖数: 70 | 2 From Golian RRP P191,
stimuli for EPO release including: hypoxemia, severe anemia, left-shift O2-
binding curve, high altitude. So I think both hypoxemia and hypoxia can
stimulate EPO release, but not ischemia, which is decreased arterial blood
flow or venouse out flow of blood, unless it is renal ischemia, where it
will be considered as hypoxia and stimulate EPO release.
Hope this would help.
【在 b*********y 的大作中提到】
: EPO感受的是hypoxemia还是 hypoxia, 包不包括ischemia? 象贫血，有hypoxia, no
: hypoxiemia, 即氧分压是正常的，但氧含量降低，有没有EPO的反应性增高？
: 谢谢
| s******n
发帖数: 2279 | 3 这种讨论非常长知识啊，我也搜索了一下
FROM
Ganong's Review of Medical Physiology
REGULATION OF SECRETION
The usual stimulus for erythropoietin secretion is hypoxia, but secretion of
the hormone can also be stimulated by cobalt
salts and androgens. Recent evidence suggests that the O2 sensor regulating
erythropoietin secretion in the kidneys and
the liver is a heme protein that in the deoxy form stimulates and in the oxy
form inhibits transcription of the
erythropoietin gene to form erythropoietin mRNA. Secretion o | b*********y
发帖数: 93 | 4 感谢NOVA和showdown的热心回答，我总结答案应该是hypoxia,对吗？只要肝脏和肾脏的
感受器(heme protein)处于脱氧状态，就会刺激肾脏的EPO分泌。所以在贫血时，尽管
氧分压正常，也会有EPO的释放。 |
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