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全部话题 - 话题: efficacy
1 2 3 4 5 6 7 8 9 10 下页 末页 (共10页)
t*******n
发帖数: 4445
1
来自主题: Medicine版 - Efficacy of flu vaccine questioned
Found another article:
"Assessment of the efficacy and effectiveness of influenza
vaccines in healthy children: systematic review"
Lancet 2005; 365: 773–80
http://cmbi.bjmu.edu.cn/news/report/2005/flu/94.pdf
Summary: World-wide literature review of flu vaccine on children up to 16
yrs. When measured in terms of lab-confirmed flu cases, live attenuated
vaccine has 79% efficacy (i.e. ideal usage) and 38% effectiveness (i.e. real
-world usage). Inactivated vaccines has 65% efficacy, and in childr
b*******n
发帖数: 3
2
Hi,
I need to combine both group mean, std and withingroup p-value, ANOVA p-
value for a phase II efficacy summary table. I plan to use proc report, but
I am not sure how to pull p-value from proc GLM/MIXED. Any reference SAS
code or books?
Thanks a lot!
s*r
发帖数: 2757
3
来自主题: Statistics版 - clinical trial efficacy analysis一问
primary efficacy按照SAP的既定方针办
exploratory 随你玩
z*******4
发帖数: 285
4
算了,你脑子大概也被活摘过
懒得跟你解释,贴个清单吧:
累计研究数量 注册号 注册日期 研究者单位 研究者单位(英文) 注
册题目 注册题目(英文) 预计纳入参试者日期
1 ChiCTR2000029308 1/23/2020 武汉市金银潭医院(武汉市传染病医院)
Wuhan Jinyintan Hospital (Wuhan Infectious Diseases Hospital) 一项评价
洛匹那韦/利托那韦和干扰素-α2b联合治疗武汉新型冠状病毒肺炎(COVID-19)住院患者
的疗效和安全性随机、开放、空白对照的研究 A randomized, open-label, blank-
controlled trial for the efficacy and safety of lopinavir-ritonavir and
interferon-alpha 2b in hospitalization patients with novel coronavirus
pneumonia (COVID-1... 阅读全帖
p********3
发帖数: 5750
5
50, 70, 71; 大家注意一下和这几篇文献相关的话题。 另外, 73-75我本人没有看,确实是谈的印度药材, 我在查阅参考文献的时候在搜索Chinese Medicine的时候, 显示有这些文献,我本人没有亲自看这些文献, 也许其中有讲中药的地方。不过这不影响我要表达的意思。
慢慢看:
INTRODUCTION — Plants have been used for medicinal purposes for thousands
of years. All major cultures including Native American, European, South
American, Asian, and African cultures have used botanicals for healing
purposes. As an example, saw palmetto was used for urinary symptoms in men
from Egypt in the 15th century BC [1]. Hippocrates documented... 阅读全帖
s**********8
发帖数: 25265
6
来自主题: MedicalDevice版 - Investigator's brochure
Investigator's brochure
From Wikipedia, the free encyclopediaJump to: navigation, search
Some of this article's sections are empty. Please add content to empty
sections. (May 2011)
This article needs additional citations for verification. Please help
improve this article by adding reliable references. Unsourced material may
be challenged and removed. (September 2009)
The Investigator's Brochure (IB) is a comprehensive document summarizing the
body of information about an investigational product ... 阅读全帖
s**********8
发帖数: 25265
7
来自主题: MedicalDevice版 - FDA
The Food and Drug Administration (FDA or USFDA) is an agency of the United
States Department of Health and Human Services, one of the United States
federal executive departments. The FDA is responsible for protecting and
promoting public health through the regulation and supervision of food
safety, tobacco products, dietary supplements, prescription and over-the-
counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals,
blood transfusions, medical devices, electromagnetic radiati... 阅读全帖
w********t
发帖数: 12853
8
我考虑到这里是中文网站。

Here at the Science-Based Medicine blog, we argue that the best medicine is
based on rigorous science. In today’s technological age, it’s easy to
forget that, throughout most of its history, medicine was not very
scientific at all. Ancient Egyptian physicians, for instance, were
invariably also priests, and for the thousands of years after them medicine
tended to be based in anecdote and mystical belief, largely because the
tools to do otherwise had not yet been developed.
Indeed, ... 阅读全帖
p********3
发帖数: 5750
9
INTRODUCTION — The word "acupuncture" is derived from the Latin words "acus
" (needle) and "punctura" (penetration). Acupuncture originated in China
approximately 2000 years ago and is one of the oldest medical procedures in
the world.
Over its long history and dissemination, acupuncture has diversified and
encompasses a large array of styles and techniques. Common styles include
Traditional Chinese, Japanese, Korean, Vietnamese, and French acupuncture,
as well as specialized forms such as hand,... 阅读全帖
b*****h
发帖数: 3386
10
http://seekingalpha.com/instablog/110813-mike-havrilla/17481-extreme-fda-calendar-trades-21-stocks-under-5
On 7/20/09, Trinity Biotech (NASDAQ:TRIB) ($4.88) announced the submission
of a CLIA application for its TRI-stat point-of-care HbA1c product to the
FDA.TRI-stat is designed to measure HbA1c, also known as glycated hemoglobin
, a measure of a patient's average blood sugar control over the trailing two
to three month period. Utilizing a patented boronate affinity and two-phase
optical system... 阅读全帖
k*****e
发帖数: 22013
11
【 以下文字转载自 ChinaNews 讨论区 】
发信人: pipigou123 (鼠姐虎弟), 信区: ChinaNews
标 题: Re: 在美国,学中医的比这里大部分人赚得多
发信站: BBS 未名空间站 (Sun Aug 14 19:55:23 2011, 美东)
INTRODUCTION — The word "acupuncture" is derived from the Latin words "acus
" (needle) and "punctura" (penetration). Acupuncture originated in China
approximately 2000 years ago and is one of the oldest medical procedures in
the world.
Over its long history and dissemination, acupuncture has diversified and
encompasses a large array of styles and techniques. ... 阅读全帖
f***r
发帖数: 5548
12
民主国屁民对政府更有信心,不爱悲愤闹事。。。
紧密团结在以种族主义为核心的资本家集团周围。。。
Still-Pending Lawsuit Alleges MMR Fraud
In 2010, two Merck virologists filed a federal lawsuit against their former
employer, alleging the vaccine maker lied about the effectiveness of the
mumps portion of its MMR II vaccine.11 The whistleblowers, Stephen Krahling
and Joan Wlochowski, claimed they witnessed “firsthand the improper testing
and data falsification in which Merck engaged to artificially inflate the
vaccine's efficacy findings.”
Accordi... 阅读全帖
j*******1
发帖数: 266
13
来自主题: Pharmaceutical版 - FDA方法的死穴是什么?
“The sponsor aims to test the efficacy and safety of a combo drug, then it
is a combo drug. Not necessary to test the efficacy and safety of each
components. Otherwise it will be multiple applications for multiple drugs.”
I never said it necessary to test the efficacy and safety of each
components, I said that you need to test different combination from a few
NCEs in a single drug to find out safety and efficacy.
What we are debating is if development of a drug with a few NCEs costs more
or much... 阅读全帖
p********3
发帖数: 5750
14
以下有文献是讲中药Lead中毒的:我懒得去筛选, 先发这个。 还有很多其他的比如癌
症的, 肾脏毒性的, 单个疾病双盲单盲科研的。我就不一一列举了。
参看50, 51, 70, 73-75.
REFERENCES 1 Wilt TJ, Ishani A, Stark G, et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. JAMA 1998; 280:1604.
2 Blumenthal M (Ed). The ABC Clinical Guide to Herbs. American Botanical Council/Thieme, New York 2003.
3 Kaptchuk TJ. Acupuncture: theory, efficacy, and practice. Ann Intern Med 2002; 136:374.
4 Farnsworth NR, Akerele O, Bingel AS, et al. Med... 阅读全帖
C*****e
发帖数: 367
15
来自主题: TrustInJesus版 - Glossary to the Westminster Confession
【 以下文字转载自 Church 俱乐部 】
发信人: CCBible (神同在圣经), 信区: Church
标 题: Glossary to the Westminster Confession
发信站: BBS 未名空间站 (Tue Apr 24 21:16:33 2012, 美东)
Glossary to the Westminster Confession
Explanations of all archaic and uncommon words, usages, and expressions, in
the order in which they occur.
Title Confession. n. Public statement of religious beliefs.
1.1 Providence. n. Divine care. Manifest. v. Show. Are they. idiom. T
hey are. Unto. prep. With regard to. Sundry. adj. Separate. D... 阅读全帖
j*****7
发帖数: 4348
16
来自主题: _pennystock版 - ZT: The Next Blockbuster Drugs
From cholesterol fighters to asthma relief, these treatments could earn Big
Pharma $170 billion
By Mike Tarsala | 24/7 Wall St.
Jul 22, 2009 | Updated: 12:29 p.m. ET Jul 22, 2009
Safety and efficacy data are critical to drug candidates. But what really
makes a potential drug attractive is strong top-line data, a new biotech-
based treatment, and a massive potential market.
With help from Thomson Reuters' SD Pharma database and our own backlog of
coverage, BioHealthInvestor.com, a 247wallst.com ... 阅读全帖
v**********m
发帖数: 5516
17
重要的时间点和market 都能在这篇文章里找到。
================
http://www.investorideas.com/CO/BPAX/news/2011/07151.asp
Mr. Stephen M. Simes, President and CEO of BioSante Pharmaceuticals, Inc. (
NASDAQ: BPAX), Discusses the Potential of Future Partners or Acquisition
Point Roberts, WA, LINCOLNSHIRE, Ill – July 15, 2011 –(Investorideas.com
newswire.com) Investorideas.com, an investor research portal covering
leading sectors including biotech and pharma stocks, features an exclusive Q
&A interview with Mr. Stephen M... 阅读全帖
r***u
发帖数: 1272
18
William Deresiewicz 2010年在斯坦福大学的演讲:
我的题目提出的问题,当然,是一个传统地面向人文科学的专业所提出的问题:学习文
学、艺术或哲学能有什么实效价值(practical value)?你肯定纳闷,我为什么在以
科技堡垒而闻名的斯坦福提出这个问题呢?大学学位给人带来众多机会,这还有什么需
要质疑的吗?
但那不是我提出的问题。这里的“做(do)”并不是指工作(job),“那(that)”并
不是指你的专业(major)。]我们不仅仅是我们的工作,教育的全部也不仅仅是一门主
修专业。(We are more than our jobs, and education is more than a major.)教
育也不仅仅是上大学,甚至也不仅是从幼儿园到研究生院的正规学校教育。我说的“你
要做什么”的意思是你要过什么样的生活(what kind of life are you going to
lead?)?我所说的“那”指的是你得到的正规或非正规的任何训练,那些把你送到这
里来的东西,你在学校的剩余时间里将要做的任何事。
我们不妨先来讨论你是如何考入斯坦福的... 阅读全帖

发帖数: 1
19
(方舟子按:近年来国外医学期刊多次发表国外临床试验结果否定了肖氏手术的有效性
。霍普金斯儿童医院最近在美国《神经外科杂志:儿科》发表几年前对肖氏手术做随机
双盲对照试验的结果,结论还是:毫无效果,不可用于临床,在做进一步的基础研究和
动物实验之前,不应再对肖氏手术做临床试验。这是最新的也是最严格(首次使用对照
)的一项研究结果,称得上是肖氏手术的最后一颗棺材钉。《神经外科杂志:儿科》同
时发表社论揭露肖传国的底细,以下是该社论的翻译,原题《社论:一个负面研究的正
面意义》)
http://fangzhouzi.baijia.baidu.com/article/435841
http://thejns.org/doi/pdf/10.3171/2015.10.PEDS15271
作者:Andrew Jea, MD
贝勒医学院神经外科系、得克萨斯儿童医院儿科神经外科部
2016年5月3日
佛罗里达州圣彼得堡的约翰森·霍普金斯儿童医院Gerald Tuite博士及其同事提交了一
项重要的研究结果,证明有争议的肖氏手术——为改善膀胱功能做体神经-自主神经转
移——对治疗脊髓脊膜突出或脂性脊髓脊膜... 阅读全帖

发帖数: 1
20
(方舟子按:近年来国外医学期刊多次发表国外临床试验结果否定了肖氏手术的有效性
。霍普金斯儿童医院最近在美国《神经外科杂志:儿科》发表几年前对肖氏手术做随机
双盲对照试验的结果,结论还是:毫无效果,不可用于临床,在做进一步的基础研究和
动物实验之前,不应再对肖氏手术做临床试验。这是最新的也是最严格(首次使用对照
)的一项研究结果,称得上是肖氏手术的最后一颗棺材钉。《神经外科杂志:儿科》同
时发表社论揭露肖传国的底细,以下是该社论的翻译,原题《社论:一个负面研究的正
面意义》)
http://thejns.org/doi/pdf/10.3171/2015.10.PEDS15271
http://fangzhouzi.baijia.baidu.com/article/440220
http://fangzhouzi.baijia.baidu.com/article/435841
作者:Andrew Jea, MD
贝勒医学院神经外科系、得克萨斯儿童医院儿科神经外科部
2016年5月3日
佛罗里达州圣彼得堡的约翰森·霍普金斯儿童医院Gerald Tuite博士及其同事提交了一
项重要的研究结果... 阅读全帖
b*****h
发帖数: 3386
21
来自主题: _pennystock版 - 2010 bio四大热点 (转载)
http://blogs.barrons.com/stockstowatchtoday/2010/05/18/mannkind-afrezza-efficacy-insufficient-says-hapoalim/tab/print/
TUESDAY, MAY 18, 2010 ET
Mannkind: Afrezza Efficacy Insufficient, Says Hapoalim
By TIERNAN RAY
It appears the Street is still divided on the usefulness of Mannkind抯 (MNKD
) 揂frezzadrug for inhaled insulin.
I noted back on April 23rd that Rodman & Renshaw抯 Simos Simeonidis was impr
essed with the fact Afrezza showed a decline in hemoglobin, termed 揌BA1C,
comparable to traditional... 阅读全帖
y*****l
发帖数: 5997
22
来自主题: _pennystock版 - Biotech Stock Live Chat
11:55 Do you think there is > 50% chance someone buys HGSI in next 12 mos.?
Yes
( 68% )No
( 32% )
Thursday October 20, 2011 11:55
11:56 adam feuerstein: Hello! Welcome to the October edition of Biotech
Stock Live Chat.
Thursday October 20, 2011 11:56 adam feuerstein
12:02 adam feuerstein: hi everyone
Thursday October 20, 2011 12:02 adam feuerstein
12:02 adam feuerstein: I'll get started in a minute or so, let folks log in
.
Thursday October 20, 2011 12:02 adam feuerstein
12:02 adam feuers... 阅读全帖

发帖数: 1
23
来自主题: Military版 - 12 月26日 可能的真相
【Filariasis
From Wikipedia, the free encyclopedia
Filariasis
Life cycle of Wuchereria bancrofti, a parasite that causes filariasis
Classification and external resources
Specialty Infectious disease
ICD-10 B74
ICD-9-CM 125.0-125.9
Patient UK Filariasis
MeSH D005368
[edit on Wikidata]
Filariasis is a parasitic disease caused by an infection with roundworms of
the Filarioidea type.[1] These are spread by blood-feeding black flies and
mosquitoes. This disease belongs to the group of d... 阅读全帖

发帖数: 1
24
来自主题: Military版 - 12月28日。 答案
12月28日 仔细阅读以下文章
或许这些文章可以告诉你们孩子被伤害病毒的答案。
Astellas Pharma 应该和这些人体实验有莫大的关系!
Founded 2005; 11 years ago
Headquarters 2-5-1, Nihonbashi-Honcho, Chūō-ku, Tokyo 103-8411, Japan
Key people Yoshihiko Katakana
(President and CEO)
Filariasis
From Wikipedia, the free encyclopedia
Filariasis
Life cycle of Wuchereria bancrofti, a parasite that causes filariasis
Classification and external resources
Specialty Infectious disease
ICD-10 B74
ICD-9-CM 125.0-125.9
Patient UK Filariasis
MeSH ... 阅读全帖
w********t
发帖数: 12853
25
NY Times 的报道,左逼媒体,你可以不信。
不过貌似这样说的是川普选的 FDA 新领导人,他本人说的是危重病人的药不需要(过
多)审查。而这位新科 FDA 一把手确实说过制药公司把药推向市场前不需要证明药物
有效
“Mr. O’Neill has argued that companies should not have to prove that their
drugs work in clinical trials before selling them to consumers.”

Trump’s F.D.A. Pick Could Undo Decades of Drug Safeguards
By KATIE THOMASFEB. 5, 2017
President Trump during a meeting with top drug executives at the White House
last week. Credit Stephen Crowley/The New York Times
President Trump’s vow to overhaul... 阅读全帖
c**i
发帖数: 6973
26
来自主题: NextGeneration版 - Re: 感觉肝功能阳性就象携带艾滋病毒
(1) Taiwan is the the first in the world to start universal vaccination
against hepatitis b virus (HBV), in 1984.
The vaccine then was produced by Merck from human serum. In 1986 California-
based Chiron Corporation succeeded in making the first recombinant vaccine,
the
hepatitis B vaccine
http://en.wikipedia.org/wiki/Hepatitis_B_vaccine
(section 1 The invention, whose reference 4 is Lawrence M Fisher,
Biotechnology Spotlight Now Shines on Chiron. New York Times, Oct 13, 1986.
http://www.nytimes... 阅读全帖
V*****2
发帖数: 7930
27
来自主题: Stock版 - CHTP-赌approve明天买,赌反弹
You can and should read Blank's entire Northera review. Here are key,
summary excerpts:
In summary, in support of approval, there is one trial (Study 301) that is
strongly supportive of efficacy of droxidopa and contains many of the
attributes of a single trial that might stand alone to support efficacy:
large and multicenter trial, improvement on multiple ordered endpoints
including OHSA Item 1, OHQ and systolic blood pressure, and statistically
very persuasive findings. From a post-hoc analysi... 阅读全帖
s****e
发帖数: 5429
28
【 以下文字转载自 USANews 讨论区 】
发信人: wonderment (wonder), 信区: USANews
标 题: Re: 这是疯了吧?!川普称「没必要证明新药有效」(转载)
发信站: BBS 未名空间站 (Tue Feb 7 15:09:56 2017, 美东)
NY Times 的报道,左逼媒体,你可以不信。
不过貌似这样说的是川普选的 FDA 新领导人,他本人说的是危重病人的药不需要(过
多)审查。而这位新科 FDA 一把手确实说过制药公司把药推向市场前不需要证明药物
有效
“Mr. O’Neill has argued that companies should not have to prove that their
drugs work in clinical trials before selling them to consumers.”
Trump’s F.D.A. Pick Could Undo Decades of Drug Safeguards
By KATIE THOMASFEB. 5, 2017
President Trump duri... 阅读全帖
v********a
发帖数: 646
29
来自主题: Biology版 - Paper help with Baozi
点击fulltext,只有这么多内容:
http://cancerdiscovery.aacrjournals.org/content/5/7/OF20.abstra
Chimeric antigen receptors (CAR) link antigen-binding domains with T-cell
signaling domains and represent potential anticancer agents. However, only
CARs targeting CD19 in hematologic malignancies have demonstrated
significant clinical efficacy. To identify the mechanisms underlying the
poor efficacy of CARs targeting other tumor antigens, Long and colleagues
compared the in vivo antitumor activity of CD19 CAR T ... 阅读全帖
j*******1
发帖数: 266
30
来自主题: Law版 - 再问一个专利问题
谢谢几位的回答。一周前,我已FILE 了provisional application to USPTO,
我把它放在下边,请大家看看:
Treating Patients with Potential Therapeutic Drugs
Major development of the Western medicine is from discovery of new medications, the United States is the country with biggest pharmaceutical companies in the world, and the companies follow the U.S. FDA guidelines. However, the guidelines have significant limitations.
Conceptually, according to the drug treatment, disease may be divided into three types.
1. Disease can be treat... 阅读全帖
y*****l
发帖数: 5997
31
来自主题: _pennystock版 - 明天反弹,关注稀土,金银,和生拉.
Celsion Reports First Quarter 2011 Financial Results and Provides Business
Update
Now - Marketwire via Comtex
MarketwireCelsion Corporation (NASDAQ: CLSN), a leading oncology drug
development company, today announced financial results for the first quarter
ended March 31, 2011 and addressed the progress of its clinical trials of
ThermoDox(R), Celsion's proprietary heat-activated liposomal encapsulation
of doxorubicin for the treatment of hepatocellular carcinoma (HCC), commonly
referred to as pr... 阅读全帖
d******8
发帖数: 1972
32
来自主题: _pennystock版 - AMRN 今天盘后ER
好像没有什么影响。
http://finance.yahoo.com/news/amarin-reports-first-quarter-2012
BEDMINSTER, N.J., and DUBLIN, Ireland, May 8, 2012 (GLOBE NEWSWIRE) --
Amarin Corporation plc (Nasdaq:AMRN - News), a late-stage biopharmaceutical
company focused on cardiovascular disease, today announced financial results
for the quarter ended March 31, 2012 and provided an update on company
operations.
Amarin noted the following highlights since the quarter ended December 31,
2011:
Received Notice of Allowance for paten... 阅读全帖
g******o
发帖数: 33
33
中国的法官太二了,看看烙印怎么玩的。
Cipla launched a generic version of valganciclovir in 2008 while the anti-
viral was under patent in India
The Indian Patent Office has reversed an earlier decision granting patent
rights to an anti-viral drug valganciclovir marketed by Roche.
Valganciclovir is used for the treatment of active cytomegalovirus (CMV)
retinitis that occur in people living with HIV.
The Indian Patent Office at Chennai, in a decision released on April 30,
2010, has set aside the patent granted to ... 阅读全帖

发帖数: 1
34
来自主题: Military版 - 中美进入你死我活新时代
12月27日 为什么我要替中国辩护
我要替中国辩护,并不是因为我是一个中国人,而是因为我知道中国就和这世界上绝大
数的国家一样,虽然有很多丑陋的现象,但是他们是受害者。就
象这个犯罪集团里很多的人一样,他们来自各种种族,他们可能充当了工具,但他们不
是制造这一切,谋划这一切的人。虽然经常会暴露中国产品出现问题。但要知道中国是
世界工厂,他们只是打工者,他们只是按照各种雇主提供的配方来生产,他们并不知道
他们会产生怎样的后果。或者这些工人知道后果,但他们只是奴隶,他们又如何去改变
这一切? 所以,当我的调查不断往前推进的时候,不可避免地会涉及各国的企业,但
这并不表明是针对这个国家或这个国家的人民,而是针对一种社会现实和丑陋现象。就
拿菲律宾来说,菲律宾是一个犯罪猖獗的国家,有很多犯罪分子,但是菲律宾人民却是
这个集团的受害者,他们/她们被绑架,沦为了牺牲品,人体实验对象。一个日本人,
强奸上千名菲律宾女孩,却没有受到惩罚。以前我也提到过,有20个国家的名单,这20
个国家的人民其实都是受害者。现在他们把矛头对准中国,或许仅仅是因为我揭示了他
们图害世界人民的内幕,而我是一个中国人的缘... 阅读全帖

发帖数: 1
35
12月27日 为什么我要替中国辩护
我要替中国辩护,并不是因为我是一个中国人,而是因为我知道中国就和这世界上绝大
数的国家一样,虽然有很多丑陋的现象,但是他们是受害者。就
象这个犯罪集团里很多的人一样,他们来自各种种族,他们可能充当了工具,但他们不
是制造这一切,谋划这一切的人。虽然经常会暴露中国产品出现问题。但要知道中国是
世界工厂,他们只是打工者,他们只是按照各种雇主提供的配方来生产,他们并不知道
他们会产生怎样的后果。或者这些工人知道后果,但他们只是奴隶,他们又如何去改变
这一切? 所以,当我的调查不断往前推进的时候,不可避免地会涉及各国的企业,但
这并不表明是针对这个国家或这个国家的人民,而是针对一种社会现实和丑陋现象。就
拿菲律宾来说,菲律宾是一个犯罪猖獗的国家,有很多犯罪分子,但是菲律宾人民却是
这个集团的受害者,他们/她们被绑架,沦为了牺牲品,人体实验对象。一个日本人,
强奸上千名菲律宾女孩,却没有受到惩罚。以前我也提到过,有20个国家的名单,这20
个国家的人民其实都是受害者。现在他们把矛头对准中国,或许仅仅是因为我揭示了他
们图害世界人民的内幕,而我是一个中国人的缘... 阅读全帖
d********t
发帖数: 837
36
就是想说看safety 也得controlled study 。有了对照实验不可能光看safety 不看
efficacy 的。如果要先安全数据再批药,efficacy数据早有了,不存在这种需要先批
安全性,再看疗效的需要。
一般来说efficacy 才是容易证明的endpoint , 要证明一个要有效是比证明一个药没
安全问题要容易很多。这种拍脑袋想出来的改革方法离大炼钢铁亩产万斤也不远了。
[在 lummy (河马·云何:no due no die) 的大作中提到:]
:你到底在说安全性还是有效性?怎么这么乱呢?
:☆ 发自 iPhone 买买提 1.23.01
s*********s
发帖数: 70
37
来自主题: NextGeneration版 - 说说我对自家娃娃的疫苗选择吧
看来有人跟我问过同样的问题啊:
http://answers.yahoo.com/question/index?qid=20111130141546AAZHa
Resolved Question
Are vaccines tested in double blind placebo controlled studies?
I mean truly unbiased studies? Do you have any links to give proof so it's
not just someone's word or statement about it? I want something completely
unbiased to help settle a debate
1 year ago Report Abuse
grindl
Best Answer - Chosen by Asker
In order to do a double blind placebo controlled study with vaccines, one
group should be give... 阅读全帖

发帖数: 1
38
来自主题: Returnee版 - 中国骨干人才正在流失海外
12月27日 为什么我要替中国辩护
我要替中国辩护,并不是因为我是一个中国人,而是因为我知道中国就和这世界上绝大
数的国家一样,虽然有很多丑陋的现象,但是他们是受害者。就
象这个犯罪集团里很多的人一样,他们来自各种种族,他们可能充当了工具,但他们不
是制造这一切,谋划这一切的人。虽然经常会暴露中国产品出现问题。但要知道中国是
世界工厂,他们只是打工者,他们只是按照各种雇主提供的配方来生产,他们并不知道
他们会产生怎样的后果。或者这些工人知道后果,但他们只是奴隶,他们又如何去改变
这一切? 所以,当我的调查不断往前推进的时候,不可避免地会涉及各国的企业,但
这并不表明是针对这个国家或这个国家的人民,而是针对一种社会现实和丑陋现象。就
拿菲律宾来说,菲律宾是一个犯罪猖獗的国家,有很多犯罪分子,但是菲律宾人民却是
这个集团的受害者,他们/她们被绑架,沦为了牺牲品,人体实验对象。一个日本人,
强奸上千名菲律宾女孩,却没有受到惩罚。以前我也提到过,有20个国家的名单,这20
个国家的人民其实都是受害者。现在他们把矛头对准中国,或许仅仅是因为我揭示了他
们图害世界人民的内幕,而我是一个中国人的缘... 阅读全帖
h*******g
发帖数: 205
39
来自主题: Stock版 - 拿着ARNA的兄di
刚看到这个帖子,说是Cramer把Belviq and Qunexs 完全说反了。个人觉得他是为MM低
价进ARNA做托儿,如果你的进价低,没准再hold一下。我还拿着,进点比较低,但是,
锁利很重要!!
Great post on ARNA message board by a doctor responding to Cramer's show
last night.....
REAL PHYSICIAN: CRAMER REBUTTAL 11-Jul-12 09:14 am A very important (but
never discussed) point about anti-obesity treatment is what real physicians
will prescribe for their patients in coming years. I have discussed with
many of my fellow M.D.s, and almost all of us are going with BELVIQ instead
of QNEXA, ... 阅读全帖
j*****a
发帖数: 489
40
New EB-1A package was just re-submitted yesterday. if approved, I will
share my new package with you.I feel the new package is much better than the
NIW package.
Google scholar was used for citation.
In past years, I learn a lot in this board. Except for the application fee,
I did not spend any other money. I never consult with lawyers. Others told
me that the lawyer fee in my district is $ 5,000 for NIW. You also can DIY.
Below is my petition letter without my husband's personal information whi... 阅读全帖
b****n
发帖数: 8
41
Address:
Email:
Cell phone:
Work phone:
Oct 28, 2013
Department of Homeland Security
USCIS Nebraska Service Center
P.O. Box 87103
Lincoln, NE 68501-7103
I-140 Immigration Visa Petition Under First Preference EB-1
Petitioner/Beneficiary: XX Z., Ph.D.
Category of Petition: Alien of Extraordinary Ability
Classification Sought: 203(b)(1)(A)
Nature of Submission: Original Submission
Dear Immigration Officer,
This letter is respectfully submitted in s... 阅读全帖
b****n
发帖数: 8
42
Address:
Email:
Cell phone:
Work phone:
Oct 28, 2013
Department of Homeland Security
USCIS Nebraska Service Center
P.O. Box 87103
Lincoln, NE 68501-7103
I-140 Immigration Visa Petition Under First Preference EB-1
Petitioner/Beneficiary: XX Z., Ph.D.
Category of Petition: Alien of Extraordinary Ability
Classification Sought: 203(b)(1)(A)
Nature of Submission: Original Submission
Dear Immigration Officer,
This letter is respectfully submitted in s... 阅读全帖
n**e
发帖数: 2026
43
来自主题: WaterWorld版 - 埃博拉,不是世界末日。 (转载)
你说话是不需要根据的,朱令从来没有对她父母谈过吴今的死,是你说的吧。你不觉得
说出这种话的人应该掌嘴吗?
Am J Chin Med. 2007;35(4):575-81.
The efficacy of Chinese medicine for SARS: a review of Chinese publications
after the crisis.
Leung PC.
Author information Institute of Chinese Medicine, The Chinese University of
Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, China.
[email protected]
(function(){try{var s,a,i,j,r,c,l,b=document.getElementsByTagName("script");l=b[b.length-1].previousSibling;a=l.getAttribute('data-cfemail');if(... 阅读全帖
l**********t
发帖数: 5754
44
来自主题: TrustInJesus版 - 【基要派版本】罗马书3:1-20

3. For what if some did not believe? shall their unbelief make the faith of
God without effect?
"
3. What indeed if some, etc. As before, while regarding the Jews as exulting
in the naked sign, he allowed them no not even a spark of glory; so now,
while considering the nature of the sign, he testifies that its virtue (
virtutem, efficacy) is not destroyed, no, not even by their inconstancy. As
then he seemed before to have intimated that whatever grace there might have
been in the sign of circu... 阅读全帖
T*****n
发帖数: 2456
45
JOINT DECLARATIONON THE DOCTRINE OF JUSTIFICATION
by the Lutheran World Federation and the Catholic Church
Preamble
1.The doctrine of justification was of central importance for the Lutheran
Reformation of the sixteenth century. It was held to be the "first and chief
article"[1] and at the same time the "ruler and judge over all other
Christian doctrines."[2] The doctrine of justification was particularly
asserted and defended in its Reformation shape and special valuation over
against the Roman... 阅读全帖
c**A
发帖数: 1474
46
This issue is exactly one of my research projects. So just give my 2
cent.
1.the efficacy of siRNA vary dramatically against the same target gene.
By far, there is NO clear rule of selection.
2.ALL software can achieve no more than 70% of accuracy of prediction,
no matter where you find it or whatever they claim themselves could
achieve.
3.There probably endless factors which could affect the efficacy of
siRNA. The real efficacy is combination of all, though some factors do
contribute more other
x*****g
发帖数: 82
47
Position 1 in Nanotechnology for Cancer Molecular Imaging
Description of project: A postdoctoral position is available immediately to
focus on using pH-activatable fluorescent nanoprobes to amplify tumor
contrast with significant background suppression for image-guided resection
of head and neck tumors (HNCA). Prospective candidates will have the
opportunity to work in a highly productive multi-disciplinary environment
with a team of experts in basic and translational research. In particular,
th... 阅读全帖
r******0
发帖数: 357
48
来自主题: Biology版 - 枪手公司的末日
BMC终于在最近做了一件值得尊敬的事情。我敢说下面的狗屎99%都是所谓的个性化生物
“信息”“润色”的畸形怪胎。一般以所谓的Meta分析或者随便下载一套狗屎基因芯片
数据,然后做一些似是而非的烂分析,发一堆垃圾,一篇文章卖给忙于召妓的医生5万
到10万。
1.
Retraction Note Open Access
Retraction Note: Impact of guidewire selection and operator expertise on
radiation exposure in transradial angiography
Jianmin Yang, Ningfu Wang, Xiaoshan Tong, Xianhua Ye, Liang Zhou, Guoxin
Tong, Yun Shen, Shuzheng Lv
Journal of Cardiothoracic Surgery 2015, 10:42 (27 March 2015)
Full text | PDF
2.
Retraction Note Open Access
Retracti... 阅读全帖
m******c
发帖数: 830
49
In a nutshell, the larger data set announced on 11/6 is not as good as the
smaller data set announce 3 days earlier and caused the crash. But, common!
53% overall response rate in melanoma is still incredible!
=====================================================
On November 3, Incyte Corporation outlined its intention to advance studies
of its wholly owned epacadostat and Merck's Keytruda into phase 3 trials for
the first line treatment of advanced metastatic melanoma. Incyte also
announced tha... 阅读全帖
m********a
发帖数: 3
50
http://www.google.com/url?q=http%3A%2F%2Fblogs.scientificameric
No one wants a hacking cough for days or weeks on end. But research
shows that it generally takes about 18 days to get over a standard cough-
based illness. Most of us grow impatient after a week or so and head to
the doctor to get a prescription. The problem with that recourse, however,
is that antibiotics are usually useless against typical respiratory
infections that cause coughs.
A new analysis shows that even tho... 阅读全帖
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